Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer

We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the mechanisms are not well understood. We characterized the biologic response of taxane-resistant and taxane-sensitive ovarian cancer models to a novel FAK inhibitor (VS-6063). We used reverse-...

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Bibliographic Details
Published in:	JNCI : Journal of the National Cancer Institute Vol. 105; no. 19; p. 1485
Main Authors:	Kang, Yu, Hu, Wei, Ivan, Cristina, Dalton, Heather J, Miyake, Takahito, Pecot, Chad V, Zand, Behrouz, Liu, Tao, Huang, Jie, Jennings, Nicholas B, Rupaimoole, Rajesha, Taylor, Morgan, Pradeep, Sunila, Wu, Sherry Y, Lu, Chunhua, Wen, Yunfei, Huang, Jianfei, Liu, Jinsong, Sood, Anil K
Format:	Journal Article
Language:	English
Published:	United States 02.10.2013
Subjects:	Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Benzamides Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Drug Resistance, Neoplasm Female Focal Adhesion Kinase 1 - antagonists & inhibitors Focal Adhesion Kinase 1 - metabolism Humans Mice Mice, Nude Odds Ratio Organic Chemicals - pharmacology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - enzymology Paclitaxel - pharmacology Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Pyrazines Sulfonamides Xenograft Model Antitumor Assays Y-Box-Binding Protein 1 - metabolism
ISSN:	1460-2105, 1460-2105
Online Access:	Get more information
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