Gentamicin Population Pharmacokinetics in Pediatric Patients—A Prospective Study with Data Analysis Using the saemix Package in R

The aminoglycoside gentamicin is used for the empirical treatment of pediatric infections. It has a narrow therapeutic window. In this prospective study at University Children’s Hospital Zurich, Switzerland, we aimed to characterize the pharmacokinetics of gentamicin in pediatric patients and predic...

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Vydané v:	Pharmaceutics Ročník 13; číslo 10; s. 1596
Hlavní autori:	Paioni, Paolo, Jäggi, Vera F., Tilen, Romy, Seiler, Michelle, Baumann, Philipp, Bräm, Dominic S., Jetzer, Carole, Haid, Robin T. U., Goetschi, Aljoscha N., Goers, Roland, Müller, Daniel, Coman Schmid, Diana, Meyer zu Schwabedissen, Henriette E., Rinn, Bernd, Berger, Christoph, Krämer, Stefanie D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 01.10.2021 MDPI
Predmet:	Antibiotics Bacteria Data analysis Data warehouses dosing regimen Drug dosages Drug resistance E coli gentamicin non-linear mixed-effects modeling Open source software open-source Pathogens Patients Pediatrics Pharmacokinetics Plasma population pharmacokinetics Public domain saemix Sepsis United States > US Switzerland non-linear mixed-effects modeling saemix gentamicin open-source dosing regimen R-project population pharmacokinetics
ISSN:	1999-4923, 1999-4923
On-line prístup:	Získať plný text
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