Motor unit number index as an individual biomarker: Reference limits of intra-individual variability over time in healthy subjects
•Motor unit number index (MUNIX) variation depends on the experience of the operator.•A 20% change in MUNIX sum score is significant.•MUNIX could be used as a biomarker in the follow-up of neuromuscular disorders. Motor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our ob...
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| Veröffentlicht in: | Clinical neurophysiology Jg. 131; H. 9; S. 2209 - 2215 |
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Elsevier B.V
01.09.2020
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| ISSN: | 1388-2457, 1872-8952, 1872-8952 |
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| Abstract | •Motor unit number index (MUNIX) variation depends on the experience of the operator.•A 20% change in MUNIX sum score is significant.•MUNIX could be used as a biomarker in the follow-up of neuromuscular disorders.
Motor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our objective is to determine the intra-individual variability over time of the MUNIX.
In 11 different hospital centres, MUNIX was assessed twice, at least 3 months apart (range 90–360 days), in tibialis anterior (TA), abductor pollicis brevis (APB), abductor digiti minimi (ADM) and deltoid muscles in 118 healthy subjects. MUNIX sum score 2, 3 and 4 were respectively the sum of the MUNIX of the TA and ADM, of the TA, APB and ADM and of the TA, APB, ADM and deltoid muscles.
The repeatability of the MUNIX was better for sum scores than for single muscle recordings. The variability of the MUNIX was independent of sex, age, interval between measurements and was lower for experienced than non-experienced operators. The 95th percentile of the coefficient of variability of the MUNIX sum score 2, 3 and 4 were respectively 22%, 18% and 15% for experienced operators.
The MUNIX technique must be performed by experienced operators on several muscles to reduce its variability and improve its reliability.
A variation of the MUNIX sum score ≥20% can be interpreted as a significant change of muscle innervation. |
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| AbstractList | •Motor unit number index (MUNIX) variation depends on the experience of the operator.•A 20% change in MUNIX sum score is significant.•MUNIX could be used as a biomarker in the follow-up of neuromuscular disorders.
Motor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our objective is to determine the intra-individual variability over time of the MUNIX.
In 11 different hospital centres, MUNIX was assessed twice, at least 3 months apart (range 90–360 days), in tibialis anterior (TA), abductor pollicis brevis (APB), abductor digiti minimi (ADM) and deltoid muscles in 118 healthy subjects. MUNIX sum score 2, 3 and 4 were respectively the sum of the MUNIX of the TA and ADM, of the TA, APB and ADM and of the TA, APB, ADM and deltoid muscles.
The repeatability of the MUNIX was better for sum scores than for single muscle recordings. The variability of the MUNIX was independent of sex, age, interval between measurements and was lower for experienced than non-experienced operators. The 95th percentile of the coefficient of variability of the MUNIX sum score 2, 3 and 4 were respectively 22%, 18% and 15% for experienced operators.
The MUNIX technique must be performed by experienced operators on several muscles to reduce its variability and improve its reliability.
A variation of the MUNIX sum score ≥20% can be interpreted as a significant change of muscle innervation. Motor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our objective is to determine the intra-individual variability over time of the MUNIX.OBJECTIVEMotor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our objective is to determine the intra-individual variability over time of the MUNIX.In 11 different hospital centres, MUNIX was assessed twice, at least 3 months apart (range 90-360 days), in tibialis anterior (TA), abductor pollicis brevis (APB), abductor digiti minimi (ADM) and deltoid muscles in 118 healthy subjects. MUNIX sum score 2, 3 and 4 were respectively the sum of the MUNIX of the TA and ADM, of the TA, APB and ADM and of the TA, APB, ADM and deltoid muscles.METHODSIn 11 different hospital centres, MUNIX was assessed twice, at least 3 months apart (range 90-360 days), in tibialis anterior (TA), abductor pollicis brevis (APB), abductor digiti minimi (ADM) and deltoid muscles in 118 healthy subjects. MUNIX sum score 2, 3 and 4 were respectively the sum of the MUNIX of the TA and ADM, of the TA, APB and ADM and of the TA, APB, ADM and deltoid muscles.The repeatability of the MUNIX was better for sum scores than for single muscle recordings. The variability of the MUNIX was independent of sex, age, interval between measurements and was lower for experienced than non-experienced operators. The 95th percentile of the coefficient of variability of the MUNIX sum score 2, 3 and 4 were respectively 22%, 18% and 15% for experienced operators.RESULTSThe repeatability of the MUNIX was better for sum scores than for single muscle recordings. The variability of the MUNIX was independent of sex, age, interval between measurements and was lower for experienced than non-experienced operators. The 95th percentile of the coefficient of variability of the MUNIX sum score 2, 3 and 4 were respectively 22%, 18% and 15% for experienced operators.The MUNIX technique must be performed by experienced operators on several muscles to reduce its variability and improve its reliability.CONCLUSIONSThe MUNIX technique must be performed by experienced operators on several muscles to reduce its variability and improve its reliability.A variation of the MUNIX sum score ≥20% can be interpreted as a significant change of muscle innervation.SIGNIFICANCEA variation of the MUNIX sum score ≥20% can be interpreted as a significant change of muscle innervation. Motor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our objective is to determine the intra-individual variability over time of the MUNIX. In 11 different hospital centres, MUNIX was assessed twice, at least 3 months apart (range 90-360 days), in tibialis anterior (TA), abductor pollicis brevis (APB), abductor digiti minimi (ADM) and deltoid muscles in 118 healthy subjects. MUNIX sum score 2, 3 and 4 were respectively the sum of the MUNIX of the TA and ADM, of the TA, APB and ADM and of the TA, APB, ADM and deltoid muscles. The repeatability of the MUNIX was better for sum scores than for single muscle recordings. The variability of the MUNIX was independent of sex, age, interval between measurements and was lower for experienced than non-experienced operators. The 95th percentile of the coefficient of variability of the MUNIX sum score 2, 3 and 4 were respectively 22%, 18% and 15% for experienced operators. The MUNIX technique must be performed by experienced operators on several muscles to reduce its variability and improve its reliability. A variation of the MUNIX sum score ≥20% can be interpreted as a significant change of muscle innervation. |
| Author | Ochsner, François Attarian, Shahram Fortanier, Etienne Lenglet, Timothee Kouton, Ludivine Pereon, Yann Beaudonnet, Guillemette Magot, Armelle Nordine, Tarik Delmont, Emilien Kribich, Hafida Verschueren, Annie Vicino, Alex Tard, Céline Bolloy, Gaëlle Wang, François Cintas, Pascal Salort-Campana, Emmanuelle Breniere, Céline Lefaucheur, Jean-Pascal Jomir, Laurent Puma, Angela Grapperon, Aude-Marie Kuntzer, Thierry Collin, Romain |
| Author_xml | – sequence: 1 givenname: Emilien orcidid: 0000-0002-5591-2774 surname: Delmont fullname: Delmont, Emilien email: emilien.delmont@ap-hm.fr organization: Referral Centre for Neuromuscular Diseases and ALS, La Timone Hospital, Marseille, France – sequence: 2 givenname: François surname: Wang fullname: Wang, François organization: Department of Neurophysiology, CHU Sart Tilman B35, 4000 Liège, Belgium – sequence: 3 givenname: Jean-Pascal surname: Lefaucheur fullname: Lefaucheur, Jean-Pascal organization: EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est-Créteil, Créteil, France; Unité de Neurophysiologie Clinique, Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France – sequence: 4 givenname: Angela surname: Puma fullname: Puma, Angela organization: Université Côte d’Azur, Peripheral Nervous System and Muscle Department, CHU Nice, France – sequence: 5 givenname: Céline surname: Breniere fullname: Breniere, Céline organization: Department of Neurology, Hospices Civiles de Lyon, France – sequence: 6 givenname: Guillemette surname: Beaudonnet fullname: Beaudonnet, Guillemette organization: Unité de Neurophysiologie Clinique et Epileptologie, CHU Bicêtre, Le Kremlin Bicêtre, France – sequence: 7 givenname: Pascal surname: Cintas fullname: Cintas, Pascal organization: Department of Neurology, Toulouse, France – sequence: 8 givenname: Romain surname: Collin fullname: Collin, Romain organization: Department of Neurophysiology, CHU Sart Tilman B35, 4000 Liège, Belgium – sequence: 9 givenname: Etienne surname: Fortanier fullname: Fortanier, Etienne organization: Referral Centre for Neuromuscular Diseases and ALS, La Timone Hospital, Marseille, France – sequence: 10 givenname: Aude-Marie surname: Grapperon fullname: Grapperon, Aude-Marie organization: Referral Centre for Neuromuscular Diseases and ALS, La Timone Hospital, Marseille, France – sequence: 11 givenname: Laurent surname: Jomir fullname: Jomir, Laurent organization: Department of Neurology, Hospices Civiles de Lyon, France – sequence: 12 givenname: Hafida surname: Kribich fullname: Kribich, Hafida organization: Referral Centre for Neuromuscular Diseases and ALS, La Timone Hospital, Marseille, France – sequence: 13 givenname: Ludivine surname: Kouton fullname: Kouton, Ludivine organization: Referral Centre for Neuromuscular Diseases and ALS, La Timone Hospital, Marseille, France – sequence: 14 givenname: Thierry surname: Kuntzer fullname: Kuntzer, Thierry organization: Nerve Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland – sequence: 15 givenname: Timothee surname: Lenglet fullname: Lenglet, Timothee organization: Department of Clinical Neurophysiology, APHP, Pitié-Salpêtrière Hospital, Paris, France – sequence: 16 givenname: Armelle surname: Magot fullname: Magot, Armelle organization: Laboratoire d'explorations fonctionnelles, Referral Centre for Neuromuscular Disease Atlantique-Occitanie-Caraïbes, Hôtel-Dieu, 44093 Nantes, France – sequence: 17 givenname: Tarik surname: Nordine fullname: Nordine, Tarik organization: EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est-Créteil, Créteil, France; Unité de Neurophysiologie Clinique, Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France – sequence: 18 givenname: François surname: Ochsner fullname: Ochsner, François organization: Nerve Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland – sequence: 19 givenname: Gaëlle surname: Bolloy fullname: Bolloy, Gaëlle organization: Laboratoire d'explorations fonctionnelles, Referral Centre for Neuromuscular Disease Atlantique-Occitanie-Caraïbes, Hôtel-Dieu, 44093 Nantes, France – sequence: 20 givenname: Yann surname: Pereon fullname: Pereon, Yann organization: Laboratoire d'explorations fonctionnelles, Referral Centre for Neuromuscular Disease Atlantique-Occitanie-Caraïbes, Hôtel-Dieu, 44093 Nantes, France – sequence: 21 givenname: Emmanuelle surname: Salort-Campana fullname: Salort-Campana, Emmanuelle organization: Referral Centre for Neuromuscular Diseases and ALS, La Timone Hospital, Marseille, France – sequence: 22 givenname: Céline surname: Tard fullname: Tard, Céline organization: U1172 Lille Neuroscience et Cognition, CHU de Lille, Centre de référence des maladies neuromusculaires Nord Est Ile de France, Department of Neurology, Lille, France – sequence: 23 givenname: Alex surname: Vicino fullname: Vicino, Alex organization: Nerve Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland – sequence: 24 givenname: Annie surname: Verschueren fullname: Verschueren, Annie organization: Referral Centre for Neuromuscular Diseases and ALS, La Timone Hospital, Marseille, France – sequence: 25 givenname: Shahram surname: Attarian fullname: Attarian, Shahram organization: Referral Centre for Neuromuscular Diseases and ALS, La Timone Hospital, Marseille, France |
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| Cites_doi | 10.1016/j.clinph.2012.08.023 10.1016/j.clinph.2019.07.021 10.1002/mus.26099 10.1136/jnnp-2015-310509 10.1371/journal.pone.0153948 10.1016/j.clinph.2018.08.025 10.1016/j.clinph.2018.04.614 10.1016/j.clinph.2018.04.748 10.1002/mus.26837 10.1016/j.clinph.2017.04.022 10.1002/mus.25595 10.1016/j.neucli.2018.09.001 10.1016/j.neucli.2019.09.001 10.1002/mus.21765 10.1016/j.clinph.2018.04.359 10.1016/j.clinph.2019.06.231 10.1002/mus.21824 10.1109/TBME.2004.834281 10.1016/j.clinph.2016.11.012 10.1016/j.clinph.2017.11.012 10.1016/j.clinph.2011.02.017 10.1016/j.clinph.2015.12.002 10.1016/j.neucli.2017.01.002 |
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| Keywords | MUNIX Repeatability Healthy subjects Normal values Variability |
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| References | Neuwirth, Nandedkar, Stålberg, Barkhaus, De Carvalho, Furtula (b0105) 2011; 122 Querin, Lenglet, Debs, Stojkovic, Behin, Salachas (b0115) 2018; 129 Nandedkar, Barkhaus, Stålberg (b0075) 2019; 130 Nandedkar, Barkhaus, Stålberg (b0070) 2010; 42 Nandedkar, Nandedkar, Barkhaus, Stalberg (b0085) 2004; 51 de Carvalho, Barkhaus, Nandedkar, Swash (b0025) 2018; 129 Ahn, Kim, Kim, Kim, Kim, Park (b0005) 2010; 42 Fatehi, Delmont, Grapperon, Salort-Campana, Sévy, Verschueren (b0035) 2017; 128 Delmont, Benvenutto, Grimaldi, Duprat, Philibert, Pouget (b0030) 2016; 127 Neuwirth, Burkhardt, Alix, Castro, De Carvalho, Gawel (b0100) 2016; 11 Philibert, Grapperon, Delmont, Attarian (b0110) 2017; 128 Zheng, Zhu, Shao, Zhu, Hu, Qiao (b0120) 2019; 49 Higashihara M, Menon P, Bos M, Pavey N, Vucic S. Reproducibility of MUNIX and MScanFit MUNE across intrinsic hand muscles. Muscle Nerve 2020; in press. doi.org/10.1002/mus.26839. Fatehi, Grapperon, Fathi, Delmont, Attarian (b0040) 2018; 48 Neuwirth, Barkhaus, Burkhardt, Castro, Czell, de Carvalho (b0090) 2015; 86 Cao, Gu, Zhang, Hou, Chen, Wei (b0020) 2020; 61 Furtula, Johnsen, Christensen, Pugdahl, Bisgaard, Christensen (b0045) 2013; 124 Gesquière-Dando, Delmont, Launay, Boucraut, Attarian (b0050) 2017; 47 Nandedkar, Barkhaus, Stålberg, Neuwirth, Weber (b0080) 2018; 58 Benmouna, Milants, Wang (b0015) 2018; 129 Bas, Delmont, Fatehi, Salort-campana, Verschueren, Pouget (b0010) 2018; 129 Grimaldi, Duprat, Grapperon, Verschueren, Delmont, Attarian (b0055) 2017; 56 Lawley, Seri, Rajabally (b0065) 2019; 130 Neuwirth, Braun, Claeys, Bucelli, Fournier, Bromberg (b0095) 2018; 129 Neuwirth (10.1016/j.clinph.2020.06.019_b0105) 2011; 122 Querin (10.1016/j.clinph.2020.06.019_b0115) 2018; 129 Zheng (10.1016/j.clinph.2020.06.019_b0120) 2019; 49 Nandedkar (10.1016/j.clinph.2020.06.019_b0085) 2004; 51 Gesquière-Dando (10.1016/j.clinph.2020.06.019_b0050) 2017; 47 Lawley (10.1016/j.clinph.2020.06.019_b0065) 2019; 130 Grimaldi (10.1016/j.clinph.2020.06.019_b0055) 2017; 56 Neuwirth (10.1016/j.clinph.2020.06.019_b0095) 2018; 129 10.1016/j.clinph.2020.06.019_b0060 Nandedkar (10.1016/j.clinph.2020.06.019_b0075) 2019; 130 Fatehi (10.1016/j.clinph.2020.06.019_b0035) 2017; 128 Neuwirth (10.1016/j.clinph.2020.06.019_b0090) 2015; 86 Neuwirth (10.1016/j.clinph.2020.06.019_b0100) 2016; 11 Delmont (10.1016/j.clinph.2020.06.019_b0030) 2016; 127 Fatehi (10.1016/j.clinph.2020.06.019_b0040) 2018; 48 Nandedkar (10.1016/j.clinph.2020.06.019_b0070) 2010; 42 Philibert (10.1016/j.clinph.2020.06.019_b0110) 2017; 128 de Carvalho (10.1016/j.clinph.2020.06.019_b0025) 2018; 129 Furtula (10.1016/j.clinph.2020.06.019_b0045) 2013; 124 Benmouna (10.1016/j.clinph.2020.06.019_b0015) 2018; 129 Bas (10.1016/j.clinph.2020.06.019_b0010) 2018; 129 Cao (10.1016/j.clinph.2020.06.019_b0020) 2020; 61 Nandedkar (10.1016/j.clinph.2020.06.019_b0080) 2018; 58 Ahn (10.1016/j.clinph.2020.06.019_b0005) 2010; 42 |
| References_xml | – volume: 58 start-page: 374 year: 2018 end-page: 380 ident: b0080 article-title: Motor unit number index: Guidelines for recording signals and their analysis publication-title: Muscle Nerve – volume: 11 year: 2016 ident: b0100 article-title: Quality control of Motor Unit Number Index (MUNIX) measurements in 6 muscles in a single-subject ‘round-robin’ setup publication-title: PLoS One – reference: Higashihara M, Menon P, Bos M, Pavey N, Vucic S. Reproducibility of MUNIX and MScanFit MUNE across intrinsic hand muscles. Muscle Nerve 2020; in press. doi.org/10.1002/mus.26839. – volume: 129 start-page: 1756 year: 2018 end-page: 1762 ident: b0095 article-title: Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres publication-title: Clin Neurophysiol – volume: 129 start-page: 2333 year: 2018 end-page: 2340 ident: b0115 article-title: The motor unit number index (MUNIX) profile of patients with adult spinal muscular atrophy publication-title: Clin Neurophysiol – volume: 129 start-page: 1390 year: 2018 end-page: 1396 ident: b0010 article-title: Motor unit number index correlates with disability in Charcot-Marie- Tooth disease publication-title: Clin Neurophysiol – volume: 129 start-page: 341 year: 2018 end-page: 344 ident: b0015 article-title: Correlations between MUNIX and adapted multiple point stimulation MUNE methods publication-title: Clin Neurophysiol – volume: 48 start-page: 251 year: 2018 end-page: 259 ident: b0040 article-title: The utility of motor unit number index: A systematic review publication-title: Neurophysiol Clin – volume: 42 start-page: 808 year: 2010 end-page: 813 ident: b0005 article-title: Reproducibility of the motor unit number index (MUNIX) in normal controls and amyotrophic lateral sclerosis patients publication-title: Muscle Nerve – volume: 86 start-page: 1172 year: 2015 end-page: 1179 ident: b0090 article-title: Tracking motor neuron loss in a set of six muscles in amyotrophic lateral sclerosis using the Motor Unit Number Index (MUNIX): a 15-month longitudinal multicentre trial publication-title: J Neurol Neurosurg Psychiatry – volume: 128 start-page: 235 year: 2017 end-page: 240 ident: b0110 article-title: Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index publication-title: Clin Neurophysiol – volume: 49 start-page: 391 year: 2019 end-page: 404 ident: b0120 article-title: Split-hand phenomenon quantified by the motor unit number index for distinguishing cervical spondylotic amyotrophy from amyotrophic lateral sclerosis publication-title: Neurophysiol Clin – volume: 129 start-page: 1507 year: 2018 end-page: 1516 ident: b0025 article-title: Motor unit number estimation (MUNE): Where are we now? publication-title: Clin Neurophysiol – volume: 130 start-page: 2010 year: 2019 end-page: 2011 ident: b0075 article-title: Motor unit number index (MUNIX) and compound muscle action potential amplitude: A reappraisal publication-title: Clin Neurophysiol – volume: 61 start-page: 657 year: 2020 end-page: 661 ident: b0020 article-title: Reference values for the motor unit number index and the motor unit size index in five muscles publication-title: Muscle Nerve – volume: 51 start-page: 2209 year: 2004 end-page: 2211 ident: b0085 article-title: Motor unit number index (MUNIX) publication-title: IEEE Trans Biomed Eng – volume: 56 start-page: 202 year: 2017 end-page: 206 ident: b0055 article-title: Global motor unit number index sum score for assessing the loss of lower motor neurons in amyotrophic lateral sclerosis publication-title: Muscle Nerve – volume: 47 start-page: 75 year: 2017 end-page: 81 ident: b0050 article-title: Are electrophysiological features related to disability in patients with anti-MAG neuropathy? publication-title: Neurophysiol Clin – volume: 124 start-page: 610 year: 2013 end-page: 618 ident: b0045 article-title: MUNIX and incremental stimulation MUNE in ALS patients and control subjects publication-title: Clin Neurophysiol – volume: 128 start-page: 1264 year: 2017 end-page: 1269 ident: b0035 article-title: Motor unit number index (MUNIX) in patients with anti-MAG neuropathy publication-title: Clin Neurophysiol – volume: 130 start-page: 1743 year: 2019 end-page: 1749 ident: b0065 article-title: Motor unit number index (MUNIX) in chronic inflammatory demyelinating polyneuropathy: A potential role in monitoring response to intravenous immunoglobulins publication-title: Clin Neurophysiol – volume: 127 start-page: 1891 year: 2016 end-page: 1894 ident: b0030 article-title: Motor unit number index (MUNIX): Is it relevant in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)? publication-title: Clin Neurophysiol – volume: 122 start-page: 1867 year: 2011 end-page: 1872 ident: b0105 article-title: Motor Unit Number Index (MUNIX): A novel neurophysiological marker for neuromuscular disorders; test-retest reliability in healthy volunteers publication-title: Clin Neurophysiol – volume: 42 start-page: 798 year: 2010 end-page: 807 ident: b0070 article-title: Motor unit number index (MUNIX): Principle, method, and findings in healthy subjects and in patients with motor neuron disease publication-title: Muscle Nerve – ident: 10.1016/j.clinph.2020.06.019_b0060 – volume: 124 start-page: 610 issue: 3 year: 2013 ident: 10.1016/j.clinph.2020.06.019_b0045 article-title: MUNIX and incremental stimulation MUNE in ALS patients and control subjects publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2012.08.023 – volume: 130 start-page: 2010 year: 2019 ident: 10.1016/j.clinph.2020.06.019_b0075 article-title: Motor unit number index (MUNIX) and compound muscle action potential amplitude: A reappraisal publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2019.07.021 – volume: 58 start-page: 374 year: 2018 ident: 10.1016/j.clinph.2020.06.019_b0080 article-title: Motor unit number index: Guidelines for recording signals and their analysis publication-title: Muscle Nerve doi: 10.1002/mus.26099 – volume: 86 start-page: 1172 year: 2015 ident: 10.1016/j.clinph.2020.06.019_b0090 article-title: Tracking motor neuron loss in a set of six muscles in amyotrophic lateral sclerosis using the Motor Unit Number Index (MUNIX): a 15-month longitudinal multicentre trial publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2015-310509 – volume: 11 year: 2016 ident: 10.1016/j.clinph.2020.06.019_b0100 article-title: Quality control of Motor Unit Number Index (MUNIX) measurements in 6 muscles in a single-subject ‘round-robin’ setup publication-title: PLoS One doi: 10.1371/journal.pone.0153948 – volume: 129 start-page: 2333 year: 2018 ident: 10.1016/j.clinph.2020.06.019_b0115 article-title: The motor unit number index (MUNIX) profile of patients with adult spinal muscular atrophy publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2018.08.025 – volume: 129 start-page: 1756 year: 2018 ident: 10.1016/j.clinph.2020.06.019_b0095 article-title: Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2018.04.614 – volume: 129 start-page: 1507 year: 2018 ident: 10.1016/j.clinph.2020.06.019_b0025 article-title: Motor unit number estimation (MUNE): Where are we now? publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2018.04.748 – volume: 61 start-page: 657 issue: 5 year: 2020 ident: 10.1016/j.clinph.2020.06.019_b0020 article-title: Reference values for the motor unit number index and the motor unit size index in five muscles publication-title: Muscle Nerve doi: 10.1002/mus.26837 – volume: 128 start-page: 1264 year: 2017 ident: 10.1016/j.clinph.2020.06.019_b0035 article-title: Motor unit number index (MUNIX) in patients with anti-MAG neuropathy publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2017.04.022 – volume: 56 start-page: 202 year: 2017 ident: 10.1016/j.clinph.2020.06.019_b0055 article-title: Global motor unit number index sum score for assessing the loss of lower motor neurons in amyotrophic lateral sclerosis publication-title: Muscle Nerve doi: 10.1002/mus.25595 – volume: 48 start-page: 251 year: 2018 ident: 10.1016/j.clinph.2020.06.019_b0040 article-title: The utility of motor unit number index: A systematic review publication-title: Neurophysiol Clin doi: 10.1016/j.neucli.2018.09.001 – volume: 49 start-page: 391 year: 2019 ident: 10.1016/j.clinph.2020.06.019_b0120 article-title: Split-hand phenomenon quantified by the motor unit number index for distinguishing cervical spondylotic amyotrophy from amyotrophic lateral sclerosis publication-title: Neurophysiol Clin doi: 10.1016/j.neucli.2019.09.001 – volume: 42 start-page: 808 issue: 5 year: 2010 ident: 10.1016/j.clinph.2020.06.019_b0005 article-title: Reproducibility of the motor unit number index (MUNIX) in normal controls and amyotrophic lateral sclerosis patients publication-title: Muscle Nerve doi: 10.1002/mus.21765 – volume: 129 start-page: 1390 issue: 7 year: 2018 ident: 10.1016/j.clinph.2020.06.019_b0010 article-title: Motor unit number index correlates with disability in Charcot-Marie- Tooth disease publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2018.04.359 – volume: 130 start-page: 1743 year: 2019 ident: 10.1016/j.clinph.2020.06.019_b0065 article-title: Motor unit number index (MUNIX) in chronic inflammatory demyelinating polyneuropathy: A potential role in monitoring response to intravenous immunoglobulins publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2019.06.231 – volume: 42 start-page: 798 year: 2010 ident: 10.1016/j.clinph.2020.06.019_b0070 article-title: Motor unit number index (MUNIX): Principle, method, and findings in healthy subjects and in patients with motor neuron disease publication-title: Muscle Nerve doi: 10.1002/mus.21824 – volume: 51 start-page: 2209 year: 2004 ident: 10.1016/j.clinph.2020.06.019_b0085 article-title: Motor unit number index (MUNIX) publication-title: IEEE Trans Biomed Eng doi: 10.1109/TBME.2004.834281 – volume: 128 start-page: 235 year: 2017 ident: 10.1016/j.clinph.2020.06.019_b0110 article-title: Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2016.11.012 – volume: 129 start-page: 341 issue: 2 year: 2018 ident: 10.1016/j.clinph.2020.06.019_b0015 article-title: Correlations between MUNIX and adapted multiple point stimulation MUNE methods publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2017.11.012 – volume: 122 start-page: 1867 year: 2011 ident: 10.1016/j.clinph.2020.06.019_b0105 article-title: Motor Unit Number Index (MUNIX): A novel neurophysiological marker for neuromuscular disorders; test-retest reliability in healthy volunteers publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2011.02.017 – volume: 127 start-page: 1891 year: 2016 ident: 10.1016/j.clinph.2020.06.019_b0030 article-title: Motor unit number index (MUNIX): Is it relevant in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)? publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2015.12.002 – volume: 47 start-page: 75 year: 2017 ident: 10.1016/j.clinph.2020.06.019_b0050 article-title: Are electrophysiological features related to disability in patients with anti-MAG neuropathy? publication-title: Neurophysiol Clin doi: 10.1016/j.neucli.2017.01.002 |
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| Snippet | •Motor unit number index (MUNIX) variation depends on the experience of the operator.•A 20% change in MUNIX sum score is significant.•MUNIX could be used as a... Motor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our objective is to determine the intra-individual variability over time of the... |
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| Title | Motor unit number index as an individual biomarker: Reference limits of intra-individual variability over time in healthy subjects |
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