Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study

Background External pilot or feasibility studies can be used to estimate key unknown parameters to inform the design of the definitive randomised controlled trial (RCT). However, there is little consensus on how large pilot studies need to be, and some suggest inflating estimates to adjust for the l...

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Vydáno v:	Trials Ročník 15; číslo 1; s. 264
Hlavní autoři:	Teare, M Dawn, Dimairo, Munyaradzi, Shephard, Neil, Hayman, Alex, Whitehead, Amy, Walters, Stephen J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 03.07.2014 BioMed Central Ltd
Témata:	Biomedicine Computer Simulation Data Interpretation, Statistical Feasibility Studies Health Sciences Humans Medicine Medicine & Public Health Models, Statistical Pilot Projects Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - statistics & numerical data Sample Size Statistics for Life Sciences United Kingdom feasibility studies binary outcomes sample size pilot studies continuous outcomes, RCTs
ISSN:	1745-6215, 1745-6215
On-line přístup:	Získat plný text
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