Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally

The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relati...

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Bibliographic Details
Published in:Viruses Vol. 11; no. 2; p. 125
Main Authors: Tsoleridis, Theocharis, Chappell, Joseph G., Onianwa, Okechukwu, Marston, Denise A., Fooks, Anthony R., Monchatre-Leroy, Elodie, Umhang, Gérald, Müller, Marcel A., Drexler, Jan F., Drosten, Christian, Tarlinton, Rachael E., McClure, Charles P., Holmes, Edward C., Ball, Jonathan K.
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 30.01.2019
MDPI
Subjects:
alphacoronavirus
Alphacoronavirus - classification
Amino acids
ancestry
Animals
Arvicolinae - virology
Asia
coronavirus
Coronavirus - genetics
Coronavirus Infections - transmission
Coronaviruses
Cytochrome
Disease transmission
Divergence
Europe
evolution
Evolution, Molecular
Genes
Genetic Variation
Genome, Viral
Genomes
Hepatitis
Life Sciences
Microbiology and Parasitology
Murinae - virology
Next-generation sequencing
Nucleotide sequence
Phylogenetics
Phylogeny
Rabbits - virology
Rats - virology
recombination
Recombination, Genetic
Regulatory sequences
Respiratory diseases
Rodentia - virology
Rodents
Santé publique et épidémiologie
Sequence Analysis, DNA
Transcription
Virology
Viruses
Asia
Europe
Poland
United Kingdom > UK
France
Germany
coronavirus
alphacoronavirus
ancestry
recombination
evolution
rodents
Evolution
Ancestry
Recombination
Coronavirus
Rodents
Alphacoronavirus
ISSN:1999-4915, 1999-4915
Online Access:Get full text
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Description
Summary:The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relative frequencies of virus-host co-divergence and cross-species transmission, we recovered longer fragments of CoV genomes from previously discovered European rodent alpha-CoVs using a combination of PCR and high-throughput sequencing. Accordingly, the full genome sequence was retrieved from the UK rat coronavirus, along with partial genome sequences from the UK field vole and Poland-resident bank vole CoVs, and a short conserved ORF1b fragment from the French rabbit CoV. Genome and phylogenetic analysis showed that despite their diverse geographic origins, all rodent alpha-CoVs formed a single monophyletic group and shared similar features, such as the same gene constellations, a recombinant beta-CoV spike gene, and similar core transcriptional regulatory sequences (TRS). These data suggest that all rodent alpha CoVs sampled so far originate from a single common ancestor, and that there has likely been a long-term association between alpha CoVs and rodents. Despite this likely antiquity, the phylogenetic pattern of the alpha-CoVs was also suggestive of relatively frequent host-jumping among the different rodent species.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v11020125