Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally

The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relati...

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Vydáno v:	Viruses Ročník 11; číslo 2; s. 125
Hlavní autoři:	Tsoleridis, Theocharis, Chappell, Joseph G., Onianwa, Okechukwu, Marston, Denise A., Fooks, Anthony R., Monchatre-Leroy, Elodie, Umhang, Gérald, Müller, Marcel A., Drexler, Jan F., Drosten, Christian, Tarlinton, Rachael E., McClure, Charles P., Holmes, Edward C., Ball, Jonathan K.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 30.01.2019 MDPI
Témata:	alphacoronavirus Alphacoronavirus - classification Amino acids ancestry Animals Arvicolinae - virology Asia coronavirus Coronavirus - genetics Coronavirus Infections - transmission Coronaviruses Cytochrome Disease transmission Divergence Europe evolution Evolution, Molecular Genes Genetic Variation Genome, Viral Genomes Hepatitis Life Sciences Microbiology and Parasitology Murinae - virology Next-generation sequencing Nucleotide sequence Phylogenetics Phylogeny Rabbits - virology Rats - virology recombination Recombination, Genetic Regulatory sequences Respiratory diseases Rodentia - virology Rodents Santé publique et épidémiologie Sequence Analysis, DNA Transcription Virology Viruses Asia Europe Poland United Kingdom > UK France Germany coronavirus alphacoronavirus ancestry recombination evolution rodents Evolution Ancestry Recombination Coronavirus Rodents Alphacoronavirus
ISSN:	1999-4915, 1999-4915
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Shrnutí:	The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relative frequencies of virus-host co-divergence and cross-species transmission, we recovered longer fragments of CoV genomes from previously discovered European rodent alpha-CoVs using a combination of PCR and high-throughput sequencing. Accordingly, the full genome sequence was retrieved from the UK rat coronavirus, along with partial genome sequences from the UK field vole and Poland-resident bank vole CoVs, and a short conserved ORF1b fragment from the French rabbit CoV. Genome and phylogenetic analysis showed that despite their diverse geographic origins, all rodent alpha-CoVs formed a single monophyletic group and shared similar features, such as the same gene constellations, a recombinant beta-CoV spike gene, and similar core transcriptional regulatory sequences (TRS). These data suggest that all rodent alpha CoVs sampled so far originate from a single common ancestor, and that there has likely been a long-term association between alpha CoVs and rodents. Despite this likely antiquity, the phylogenetic pattern of the alpha-CoVs was also suggestive of relatively frequent host-jumping among the different rodent species.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v11020125