A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals

Background Hypertension (HT) and chronic kidney diseases (CKD) are complex conditions having both genetic and environmental contributions, disproportionately affecting African American (AA) individuals. Recent evidence is contradictory regarding the directionality of the relationship between the two...

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Bibliographic Details
Published in:	BMC nephrology Vol. 26; no. 1; pp. 524 - 11
Main Authors:	Kakar, Aastha, Litkowski, Elizabeth M., Scadden, Ashley W., Anwar, Mohammad Y., Konigsberg, Iain R., Stanislawski, Maggie A., DuPre, Natalie C., Mitra, Riten, Baumgartner, Richard, Raffield, Laura M., Lange, Ethan M., Lange, Leslie A., Taylor, Kira C.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 26.09.2025 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	African american individuals African Americans Antihypertensives Blood pressure Chronic kidney disease Chronic kidney failure Complications and side effects Ethnicity Genetic aspects Genomes Health aspects Health risk assessment Hypertension Internal Medicine Kidney diseases Medical research Medicine Medicine & Public Health Medicine, Experimental Nephrology Physiological aspects Polygenic inheritance Polygenic risk scores Premature mortality Regression analysis Risk factors Urine United States Polygenic risk scores Hypertension Chronic kidney disease African american individuals
ISSN:	1471-2369, 1471-2369
Online Access:	Get full text
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