NOX5: from basic biology to signaling and disease

In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1–5, DUOX1, and DUOX2. All of these enzymes function to move an electron across cellular membranes, transferring it to oxygen to generate the superoxide anion. This generation of reactive oxygen species has important physi...

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Vydáno v:	Free radical biology & medicine Ročník 52; číslo 4; s. 725 - 734
Hlavní autoři:	Bedard, Karen, Jaquet, Vincent, Krause, Karl-Heinz
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 15.02.2012
Témata:	Amino Acid Sequence Animals cell membranes enzymes Evolution, Molecular Free radicals genes Humans Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - physiology Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - physiology mice Molecular Sequence Data NADPH oxidase NADPH Oxidase 5 NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - chemistry NADPH Oxidases - genetics NADPH Oxidases - physiology NOX5 Organ Specificity oxygen Polymorphism, Single Nucleotide Protein Structure, Tertiary rats Reactive oxygen species superoxide anion Superoxides - metabolism Reactive oxygen species NOX5 Free radicals NADPH oxidase
ISSN:	0891-5849, 1873-4596, 1873-4596
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Abstract	In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1–5, DUOX1, and DUOX2. All of these enzymes function to move an electron across cellular membranes, transferring it to oxygen to generate the superoxide anion. This generation of reactive oxygen species has important physiological and pathophysiological roles. NOX5 is perhaps the least well understood of these NOX isoforms, in part because the gene is not present in mice or rats. In recent years, however, there has been a rapid increase in our understanding of the NOX5 gene, the structural and biochemical aspects of the NOX5 enzyme, the role NOX5 plays in health and disease, and the development of novel NOX inhibitors. This review takes a look back at some historical aspects of the discovery of NOX5 and summarizes our current understanding of the enzyme. ► NOX5 is a member of the NOX NADPH family of enzymes. ► It generates superoxide in response to elevated calcium. ► Here we review aspects of the NOX5 gene and its role in health and disease and discuss NOX5 inhibitors.
AbstractList	In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1–5, DUOX1, and DUOX2. All of these enzymes function to move an electron across cellular membranes, transferring it to oxygen to generate the superoxide anion. This generation of reactive oxygen species has important physiological and pathophysiological roles. NOX5 is perhaps the least well understood of these NOX isoforms, in part because the gene is not present in mice or rats. In recent years, however, there has been a rapid increase in our understanding of the NOX5 gene, the structural and biochemical aspects of the NOX5 enzyme, the role NOX5 plays in health and disease, and the development of novel NOX inhibitors. This review takes a look back at some historical aspects of the discovery of NOX5 and summarizes our current understanding of the enzyme. ► NOX5 is a member of the NOX NADPH family of enzymes. ► It generates superoxide in response to elevated calcium. ► Here we review aspects of the NOX5 gene and its role in health and disease and discuss NOX5 inhibitors. In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1–5, DUOX1, and DUOX2. All of these enzymes function to move an electron across cellular membranes, transferring it to oxygen to generate the superoxide anion. This generation of reactive oxygen species has important physiological and pathophysiological roles. NOX5 is perhaps the least well understood of these NOX isoforms, in part because the gene is not present in mice or rats. In recent years, however, there has been a rapid increase in our understanding of the NOX5 gene, the structural and biochemical aspects of the NOX5 enzyme, the role NOX5 plays in health and disease, and the development of novel NOX inhibitors. This review takes a look back at some historical aspects of the discovery of NOX5 and summarizes our current understanding of the enzyme. In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1-5, DUOX1, and DUOX2. All of these enzymes function to move an electron across cellular membranes, transferring it to oxygen to generate the superoxide anion. This generation of reactive oxygen species has important physiological and pathophysiological roles. NOX5 is perhaps the least well understood of these NOX isoforms, in part because the gene is not present in mice or rats. In recent years, however, there has been a rapid increase in our understanding of the NOX5 gene, the structural and biochemical aspects of the NOX5 enzyme, the role NOX5 plays in health and disease, and the development of novel NOX inhibitors. This review takes a look back at some historical aspects of the discovery of NOX5 and summarizes our current understanding of the enzyme.In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1-5, DUOX1, and DUOX2. All of these enzymes function to move an electron across cellular membranes, transferring it to oxygen to generate the superoxide anion. This generation of reactive oxygen species has important physiological and pathophysiological roles. NOX5 is perhaps the least well understood of these NOX isoforms, in part because the gene is not present in mice or rats. In recent years, however, there has been a rapid increase in our understanding of the NOX5 gene, the structural and biochemical aspects of the NOX5 enzyme, the role NOX5 plays in health and disease, and the development of novel NOX inhibitors. This review takes a look back at some historical aspects of the discovery of NOX5 and summarizes our current understanding of the enzyme.
Author	Bedard, Karen Jaquet, Vincent Krause, Karl-Heinz
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Snippet	In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1–5, DUOX1, and DUOX2. All of these enzymes function to move an electron across... In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1-5, DUOX1, and DUOX2. All of these enzymes function to move an electron across...
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SubjectTerms	Amino Acid Sequence Animals cell membranes enzymes Evolution, Molecular Free radicals genes Humans Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - physiology Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - physiology mice Molecular Sequence Data NADPH oxidase NADPH Oxidase 5 NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - chemistry NADPH Oxidases - genetics NADPH Oxidases - physiology NOX5 Organ Specificity oxygen Polymorphism, Single Nucleotide Protein Structure, Tertiary rats Reactive oxygen species superoxide anion Superoxides - metabolism
Title	NOX5: from basic biology to signaling and disease
URI	https://dx.doi.org/10.1016/j.freeradbiomed.2011.11.023 https://www.ncbi.nlm.nih.gov/pubmed/22182486 https://www.proquest.com/docview/1678571853 https://www.proquest.com/docview/918579696
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