Different roles of astrocytes in the blood-brain barrier during the acute and recovery phases of stroke

Ischemic stroke, a frequently occurring form of stroke, is caused by obstruction of cerebral blood flow, which leads to ischemia, hypoxia, and necrosis of local brain tissue. After ischemic stroke, both astrocytes and the blood-brain barrier undergo morphological and functional transformations. Howe...

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Vydáno v:Neural regeneration research Ročník 21; číslo 4; s. 1359 - 1372
Hlavní autoři: Cheng, Jialin, Zheng, Yuxiao, Cheng, Fafeng, Wang, Chunyu, Han, Jinhua, Zhang, Haojia, Lan, Xin, Zhang, Chuxin, Wang, Xueqian, Wang, Qingguo, Li, Changxiang
Médium: Journal Article
Jazyk:angličtina
Vydáno: India Wolters Kluwer - Medknow 01.04.2026
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Vydání:2
Témata:
astrocytes
axon
Blood-brain barrier
cytokines
endothelial cells
glial scar
Growth factors
Ischemia
ischemic stroke
Morphology
phenotype
remodel
Review
vascular
blood-brain barrier
phenotype
endothelial cells
glial scar
remodel
cytokines
astrocytes
axon
vascular
ischemic stroke
blood–brain barrier
ISSN:1673-5374, 1876-7958
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Abstract Ischemic stroke, a frequently occurring form of stroke, is caused by obstruction of cerebral blood flow, which leads to ischemia, hypoxia, and necrosis of local brain tissue. After ischemic stroke, both astrocytes and the blood-brain barrier undergo morphological and functional transformations. However, the interplay between astrocytes and the blood-brain barrier has received less attention. This comprehensive review explores the physiological and pathological morphological and functional changes in astrocytes and the blood-brain barrier in ischemic stroke. Post-stroke, the structure of endothelial cells and peripheral cells undergoes alterations, causing disruption of the blood-brain barrier. This disruption allows various pro-inflammatory factors and chemokines to cross the blood-brain barrier. Simultaneously, astrocytes swell and primarily adopt two phenotypic states: A1 and A2, which exhibit different roles at different stages of ischemic stroke. During the acute phase, A1 reactive astrocytes secrete vascular endothelial growth factor, matrix metalloproteinases, lipid carrier protein-2, and other cytokines, exacerbating damage to endothelial cells and tight junctions. Conversely, A2 reactive astrocytes produce pentraxin 3, Sonic hedgehog, angiopoietin-1, and other protective factors for endothelial cells. Furthermore, astrocytes indirectly influence blood-brain barrier permeability through ferroptosis and exosomes. In the middle and late (recovery) stages of ischemic stroke, A1 and A2 astrocytes show different effects on glial scar formation. A1 astrocytes promote glial scar formation and inhibit axon growth via glial fibrillary acidic protein, chondroitin sulfate proteoglycans, and transforming growth factor-β. In contrast, A2 astrocytes facilitate axon growth through platelet-derived growth factor, playing a crucial role in vascular remodeling. Therefore, enhancing our understanding of the pathological changes and interactions between astrocytes and the blood-brain barrier is a vital therapeutic target for preventing further brain damage in acute stroke. These insights may pave the way for innovative therapeutic strategies for ischemic stroke.
AbstractList Ischemic stroke, a frequently occurring form of stroke, is caused by obstruction of cerebral blood flow, which leads to ischemia, hypoxia, and necrosis of local brain tissue. After ischemic stroke, both astrocytes and the blood-brain barrier undergo morphological and functional transformations. However, the interplay between astrocytes and the blood-brain barrier has received less attention. This comprehensive review explores the physiological and pathological morphological and functional changes in astrocytes and the blood-brain barrier in ischemic stroke. Post-stroke, the structure of endothelial cells and peripheral cells undergoes alterations, causing disruption of the blood-brain barrier. This disruption allows various pro-inflammatory factors and chemokines to cross the blood-brain barrier. Simultaneously, astrocytes swell and primarily adopt two phenotypic states: A1 and A2, which exhibit different roles at different stages of ischemic stroke. During the acute phase, A1 reactive astrocytes secrete vascular endothelial growth factor, matrix metalloproteinases, lipid carrier protein-2, and other cytokines, exacerbating damage to endothelial cells and tight junctions. Conversely, A2 reactive astrocytes produce pentraxin 3, Sonic hedgehog, angiopoietin-1, and other protective factors for endothelial cells. Furthermore, astrocytes indirectly influence blood-brain barrier permeability through ferroptosis and exosomes. In the middle and late (recovery) stages of ischemic stroke, A1 and A2 astrocytes show different effects on glial scar formation. A1 astrocytes promote glial scar formation and inhibit axon growth via glial fibrillary acidic protein, chondroitin sulfate proteoglycans, and transforming growth factor-β. In contrast, A2 astrocytes facilitate axon growth through platelet-derived growth factor, playing a crucial role in vascular remodeling. Therefore, enhancing our understanding of the pathological changes and interactions between astrocytes and the blood-brain barrier is a vital therapeutic target for preventing further brain damage in acute stroke. These insights may pave the way for innovative therapeutic strategies for ischemic stroke.
Ischemic stroke, a frequently occurring form of stroke, is caused by obstruction of cerebral blood flow, which leads to ischemia, hypoxia, and necrosis of local brain tissue. After ischemic stroke, both astrocytes and the blood-brain barrier undergo morphological and functional transformations. However, the interplay between astrocytes and the blood-brain barrier has received less attention. This comprehensive review explores the physiological and pathological morphological and functional changes in astrocytes and the blood-brain barrier in ischemic stroke. Post-stroke, the structure of endothelial cells and peripheral cells undergoes alterations, causing disruption of the blood-brain barrier. This disruption allows various pro-inflammatory factors and chemokines to cross the blood-brain barrier. Simultaneously, astrocytes swell and primarily adopt two phenotypic states: A1 and A2, which exhibit different roles at different stages of ischemic stroke. During the acute phase, A1 reactive astrocytes secrete vascular endothelial growth factor, matrix metalloproteinases, lipid carrier protein-2, and other cytokines, exacerbating damage to endothelial cells and tight junctions. Conversely, A2 reactive astrocytes produce pentraxin 3, Sonic hedgehog, angiopoietin-1, and other protective factors for endothelial cells. Furthermore, astrocytes indirectly influence blood-brain barrier permeability through ferroptosis and exosomes. In the middle and late (recovery) stages of ischemic stroke, A1 and A2 astrocytes show different effects on glial scar formation. A1 astrocytes promote glial scar formation and inhibit axon growth via glial fibrillary acidic protein, chondroitin sulfate proteoglycans, and transforming growth factor-β. In contrast, A2 astrocytes facilitate axon growth through platelet-derived growth factor, playing a crucial role in vascular remodeling. Therefore, enhancing our understanding of the pathological changes and interactions between astrocytes and the blood-brain barrier is a vital therapeutic target for preventing further brain damage in acute stroke. These insights may pave the way for innovative therapeutic strategies for ischemic stroke.Ischemic stroke, a frequently occurring form of stroke, is caused by obstruction of cerebral blood flow, which leads to ischemia, hypoxia, and necrosis of local brain tissue. After ischemic stroke, both astrocytes and the blood-brain barrier undergo morphological and functional transformations. However, the interplay between astrocytes and the blood-brain barrier has received less attention. This comprehensive review explores the physiological and pathological morphological and functional changes in astrocytes and the blood-brain barrier in ischemic stroke. Post-stroke, the structure of endothelial cells and peripheral cells undergoes alterations, causing disruption of the blood-brain barrier. This disruption allows various pro-inflammatory factors and chemokines to cross the blood-brain barrier. Simultaneously, astrocytes swell and primarily adopt two phenotypic states: A1 and A2, which exhibit different roles at different stages of ischemic stroke. During the acute phase, A1 reactive astrocytes secrete vascular endothelial growth factor, matrix metalloproteinases, lipid carrier protein-2, and other cytokines, exacerbating damage to endothelial cells and tight junctions. Conversely, A2 reactive astrocytes produce pentraxin 3, Sonic hedgehog, angiopoietin-1, and other protective factors for endothelial cells. Furthermore, astrocytes indirectly influence blood-brain barrier permeability through ferroptosis and exosomes. In the middle and late (recovery) stages of ischemic stroke, A1 and A2 astrocytes show different effects on glial scar formation. A1 astrocytes promote glial scar formation and inhibit axon growth via glial fibrillary acidic protein, chondroitin sulfate proteoglycans, and transforming growth factor-β. In contrast, A2 astrocytes facilitate axon growth through platelet-derived growth factor, playing a crucial role in vascular remodeling. Therefore, enhancing our understanding of the pathological changes and interactions between astrocytes and the blood-brain barrier is a vital therapeutic target for preventing further brain damage in acute stroke. These insights may pave the way for innovative therapeutic strategies for ischemic stroke.
Author Zhang, Haojia
Cheng, Jialin
Han, Jinhua
Lan, Xin
Wang, Xueqian
Zhang, Chuxin
Cheng, Fafeng
Wang, Qingguo
Li, Changxiang
Zheng, Yuxiao
Wang, Chunyu
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Cites_doi 10.3389/fncel.2023.1125412
10.1016/j.neuroscience.2014.02.036
10.1016/j.redox.2018.11.017
10.1038/nature17623
10.1113/jphysiol.2007.129007
10.3389/fneur.2020.00703
10.1523/JNEUROSCI.0115-20.2020
10.1038/s12276-023-01111-z
10.14336/AD.2021.1029
10.1007/s12031-011-9584-5
10.3389/fimmu.2020.01024
10.1038/nn.4288
10.1016/j.freeradbiomed.2024.03.019
10.1038/s41420-020-00346-3
10.1007/s10571-019-00654-y
10.1161/STROKEAHA.108.534503
10.1016/S0169-328X(03)00088-3
10.1016/j.jep.2023.116597
10.1111/jnc.16021
10.3389/fphar.2021.666790
10.1038/sj.cdd.4401803
10.1093/brain/awl165
10.1242/jcs.113.10.1771
10.1186/s12974-014-0227-y
10.1161/01.ATV.0000105902.89459.09
10.1016/j.cryobiol.2007.08.009
10.1038/nm.3407
10.1186/s12964-021-00808-w
10.1006/mvre.2001.2367
10.1016/j.immuni.2017.06.006
10.1186/s12974-022-02533-8
10.1111/jcmm.70004
10.1002/glia.24151
10.4103/NRR.NRR-D-23-01385
10.1016/j.cmet.2020.03.005
10.1038/s41593-019-0497-x
10.1073/pnas.1509047112
10.1016/j.neuron.2013.12.034
10.1016/j.biomaterials.2024.122868
10.1016/j.pneurobio.2015.09.008
10.1016/j.biomaterials.2025.123102
10.3389/fnagi.2021.751304
10.1002/glia.22383
10.1002/glia.20537
10.1016/j.brainresbull.2019.04.013
10.1016/j.arr.2021.101335
10.1097/00004647-200103000-00002
10.1074/jbc.M305835200
10.1523/JNEUROSCI.0587-16.2016
10.1161/STROKEAHA.114.007145
10.1113/jphysiol.2007.146852
10.1016/j.it.2016.06.006
10.1007/s00401-018-1815-1
10.1002/jnr.20819
10.1126/science.aao2861
10.1152/ajpregu.00536.2007
10.1038/nature09513
10.14336/AD.2021.1121
10.1161/STROKEAHA.106.481515
10.1038/s41419-022-05043-w
10.1016/j.biopha.2020.110125
10.1161/01.STR.25.8.1658
10.1161/STROKEAHA.115.012133
10.1038/nature09522
10.1074/jbc.273.45.29745
10.1038/ncb1486
10.1186/s12974-020-01784-7
10.1091/mbc.e04-12-1089
10.1136/svn-2018-000198
10.1038/nm1387
10.1126/science.1206936
10.1001/jama.2022.1420
10.1161/STROKEAHA.114.007445
10.1038/ncomms10523
10.1002/glia.22676
10.1038/jcbfm.2013.224
10.4103/1673-5374.285001
10.1002/ptr.5712
10.3389/fimmu.2020.573256
10.1186/s12951-023-02110-y
10.1002/glia.20453
10.1161/01.STR.28.3.564
10.1371/journal.pone.0068891
10.1038/jcbfm.2009.248
10.1016/j.jaut.2015.12.004
10.1161/01.STR.0000253500.32979.d1
10.1073/pnas.1800165115
10.1038/sj.jcbfm.9600229
10.1007/s12035-018-1396-y
10.1016/j.neulet.2013.12.071
10.1038/s41419-019-1716-9
10.1016/0169-328X(94)00232-4
10.1016/j.lfs.2021.119715
10.1155/2022/3855698
10.3390/cells9030643
10.1016/j.pneurobio.2017.10.001
10.1038/15693
10.1161/CIRCRESAHA.116.308427
10.1016/j.jconrel.2023.11.002
10.1002/glia.23888
10.1152/physrev.00042.2016
10.1038/nature21029
10.1523/JNEUROSCI.3900-05.2006
10.1006/mvre.2002.2413
10.1038/nrn1252
10.1016/j.neuron.2014.03.003
10.2174/1570159X21666230718104634
10.1097/CCM.0000000000000993
10.1016/j.biomaterials.2018.07.014
10.1111/acel.13236
10.1007/s10456-021-09796-4
10.1016/j.neulet.2013.02.046
10.1111/j.1440-1789.2012.01322.x
10.1523/JNEUROSCI.2121-13.2013
10.3389/fncel.2020.594170
10.1056/NEJM199702273360907
10.1038/jcbfm.2014.199
10.1016/j.phymed.2024.155530
10.1080/01616412.2021.1981106
10.2174/0113895575277359231210145922
10.1016/0006-2952(84)90099-6
10.1016/j.celrep.2021.109048
10.1016/S0169-328X(98)00122-3
10.1016/j.pneurobio.2016.08.001
10.1111/bph.15961
10.1007/s00401-008-0364-4
10.1016/j.pneurobio.2020.101963
10.1007/s10571-020-00889-0
10.4103/NRR.NRR-D-23-01322
10.1124/pharmrev.120.000025
10.1016/j.molmed.2015.03.006
10.1016/S1474-4422(14)70117-6
10.1016/j.brainres.2010.10.002
10.1007/s00441-008-0688-3
10.1186/s12974-019-1556-7
10.1007/s12975-023-01170-4
10.1007/s00401-022-02452-1
10.1038/ncb1752
10.1016/0301-0082(83)90013-8
10.7150/thno.52436
10.4103/1673-5374.324858
10.3389/fncel.2018.00372
10.4103/NRR.NRR-D-24-00568
10.1097/01.LAB.0000018829.49754.DD
10.1002/advs.202410889
10.1016/j.cytogfr.2024.06.002
10.1038/nm1787
10.1212/WNL.0000000000207460
10.1161/STROKEAHA.113.000736
10.1038/s41467-017-00037-1
10.3389/fphar.2018.00518
10.1016/j.celrep.2021.108829
10.1002/glia.22489
10.1016/j.neuint.2021.105080
10.1016/j.neulet.2011.04.043
10.3389/fnagi.2022.830569
10.1002/jbt.23827
10.1038/nature07534
10.1038/aps.2015.39
10.1161/STROKEAHA.118.020927
10.1089/ars.2020.8148
10.1161/STROKEAHA.110.608257
10.1097/00004647-199906000-00005
10.1002/glia.23174
10.1038/nrn1824
10.1186/s12987-024-00510-2
10.1007/s11010-016-2866-z
10.1038/s41573-022-00390-x
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Keywords blood-brain barrier
phenotype
endothelial cells
glial scar
remodel
cytokines
astrocytes
axon
vascular
ischemic stroke
blood–brain barrier
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References Wang (R143-20250630) 2024; 15
Bauer (R8-20250630) 2010; 30
Raposo (R107-20250630) 2014; 62
de Brito (R25-20250630) 2008; 456
Gao (R43-20250630) 2023; 180
Duz (R34-20250630) 2007; 55
Linnerbauer (R84-20250630) 2020; 11
Saito (R112-20250630) 2011; 497
Förster (R42-20250630) 2008; 586
Zhang (R172-20250630) 2018; 9
Tsao (R132-20250630) 2021; 24
Wu (R151-20250630) 2024; 38
Lu (R90-20250630) 2020; 40
Shi (R118-20250630) 2024; 168
Ribeiro (R108-20250630) 2006; 83
Zhou (R179-20250630) 2020; 15
Shen (R117-20250630) 2005; 16
Walz (R136-20250630) 1983; 20
Fisher (R40-20250630) 2013; 44
Ward (R147-20250630) 2014; 13
Hu (R63-20250630) 2017; 120
Nusrat (R100-20250630) 2000; 113
Campisi (R12-20250630) 2018; 180
Gavard (R46-20250630) 2006; 8
Hu (R62-20250630) 2011; 1367
Guo (R52-20250630) 2021; 69
Wang (R145-20250630) 2025; 12
Spitzer (R125-20250630) 2022; 144
Williamson (R150-20250630) 2021; 35
Tan (R131-20250630) 2006; 26
Saldaña (R111-20250630) 2016; 68
Hou (R60-20250630) 2024; 21
Steiner (R126-20250630) 2012; 60
Verkhratsky (R134-20250630) 2018; 98
Donnini (R31-20250630) 2006; 13
Wang (R140-20250630) 2020; 21
Liddelow (R82-20250630) 2017; 46
Price (R106-20250630) 2021; 68
Gris (R51-20250630) 2007; 55
Vazana (R133-20250630) 2016; 36
Förster (R41-20250630) 2007; 580
Zhao (R177-20250630) 2019; 16
Rodriguez-Grande (R110-20250630) 2014; 34
Clarke (R18-20250630) 2018; 115
Zhang (R168-20250630) 2020; 14
Hayes (R54-20250630) 2021; 13
Shindo (R120-20250630) 2016; 47
Yu (R165-20250630) 2021; 280
Chen (R14-20250630) 2020; 19
Hisatomi (R58-20250630) 2002; 82
Yu (R164-20250630) 2012; 46
Hu (R64-20250630) 2022; 13
Cua (R21-20250630) 2013; 61
Wang (R137-20250630) 2020; 9
Wu (R152-20250630) 2015; 36
You (R162-20250630) 2022; 13
Duarte (R32-20250630) 2021; 35
Prager (R105-20250630) 2015; 21
Yu (R166-20250630) 2022; 17
Rodriguez-Grande (R109-20250630) 2015; 12
Bai (R6-20250630) 2023; 364
Xin (R156-20250630) 2013; 542
Yeung (R161-20250630) 2008; 115
Chen (R16-20250630) 2015; 46
Anderson (R4-20250630) 2016; 532
Hoffmann (R59-20250630) 2018; 49
Schmid-Brunclik (R113-20250630) 2008; 295
Diniz (R30-20250630) 2019; 56
Knowland (R70-20250630) 2014; 82
Walter (R135-20250630) 2022; 327
Feng (R38-20250630) 2023; 17
Sivandzade (R123-20250630) 2019; 21
Taddei (R130-20250630) 2008; 10
Xiao (R155-20250630) 2025; 317
Kim (R69-20250630) 2017; 65
Lee (R75-20250630) 2007; 38
Wang (R144-20250630) 2024; 28
Xia (R153-20250630) 2013; 8
Zheng (R178-20250630) 2025; 20
Zhang (R171-20250630) 2020; 6
Alvarez (R2-20250630) 2011; 334
Mendez (R92-20250630) 2003; 112
Xu (R157-20250630) 2019; 4
Beilharz (R10-20250630) 1998; 59
Dimitrijevic (R29-20250630) 2006; 26
Xiao (R154-20250630) 2024; 217
Heo (R56-20250630) 1999; 19
Yang (R160-20250630) 2011; 42
Wang (R139-20250630) 2015; 19
Krueger (R71-20250630) 2015; 35
Simionescu (R122-20250630) 2009; 335
Weinl (R149-20250630) 2015; 112
Zhao (R176-20250630) 2022; 44
Nguyen (R99-20250630) 2016; 30
Zhao (R175-20250630) 2007; 38
Hayes (R55-20250630) 2023
Messing (R94-20250630) 1998; 152
Chen (R13-20250630) 2019; 10
Kumari (R73-20250630) 2024; 78
Meng (R93-20250630) 2014; 267
Seregi (R116-20250630) 1984; 33
Song (R124-20250630) 2021; 199
Mishra (R95-20250630) 2024; 16
Zhang (R170-20250630) 2024; 128
Zhao (R174-20250630) 2006; 12
Huang (R66-20250630) 2022; 2022
Bani-Sadr (R7-20250630) 2023; 101
Burda (R11-20250630) 2014; 81
Claus (R19-20250630) 2013; 33
Peterson (R104-20250630) 2011; 2011
Colombo (R20-20250630) 2016; 37
Krupinski (R72-20250630) 1997; 28
Chen (R15-20250630) 2018; 12
Abbott (R1-20250630) 2006; 7
Delafontaine (R26-20250630) 2004; 24
Davaanyam (R24-20250630) 2023; 55
Gӧbel (R53-20250630) 2020; 31
Liang (R79-20250630) 2020; 11
Su (R127-20250630) 2008; 14
Wei (R148-20250630) 2023; 313
Garcia (R45-20250630) 1993; 142
Goldberg (R49-20250630) 1999; 1
Liu (R89-20250630) 2016; 144
Dhandapani (R28-20250630) 2003; 278
Dunn (R33-20250630) 2001; 21
Beilharz (R9-20250630) 1995; 29
Fan (R35-20250630) 2021; 148
Ghosh (R48-20250630) 2015; 43
Armulik (R5-20250630) 2010; 468
Lee (R76-20250630) 2022; 21
Wanner (R146-20250630) 2013; 33
Gao (R44-20250630) 2023; 21
Fanning (R36-20250630) 1998; 273
Yang (R159-20250630) 2021; 41
Liu (R85-20250630) 2022; 19
Yu (R163-20250630) 2021; 12
Segarra (R115-20250630) 2018; 361
Shi (R119-20250630) 2016; 7
Deng (R27-20250630) 2021; 11
Liang (R80-20250630) 2023; 21
Sweeney (R129-20250630) 2016; 19
Munji (R97-20250630) 2019; 22
Amiry-Moghaddam (R3-20250630) 2003; 4
Schulz (R114-20250630) 2023; 75
Wang (R142-20250630) 2020; 127
Zhang (R173-20250630) 2024; 19
Gelderblom (R47-20250630) 2009; 40
Obermeier (R101-20250630) 2013; 19
He (R57-20250630) 2010; 22
Lee (R77-20250630) 2022; 70
Hsiao (R61-20250630) 2007; 55
Yang (R158-20250630) 1994; 25
Liebner (R83-20250630) 2018; 135
Zhang (R169-20250630) 2022; 13
Liu (R86-20250630) 2020; 11
Lv (R91-20250630) 2019; 39
Li (R78-20250630) 2025; 314
Pekny (R103-20250630) 2014; 565
Wang (R138-20250630) 2022; 14
Chen (R17-20250630) 2024; 15
Morizawa (R96-20250630) 2017; 8
Fischer (R39-20250630) 2002; 63
Liddelow (R81-20250630) 2017; 541
Le Roith (R74-20250630) 1997; 336
Patel (R102-20250630) 2021; 34
Gonul (R50-20250630) 2002; 64
Shu (R121-20250630) 2017; 425
Jing (R68-20250630) 2020; 17
Huang (R65-20250630) 2019; 149
Liu (R88-20250630) 2025; 20
Cui (R22-20250630) 2015; 46
Jiang (R67-20250630) 2018; 163-164
Feng (R37-20250630) 2024; 24
Liu (R87-20250630) 2025; 20
Suk (R128-20250630) 2016; 144
Myer (R98-20250630) 2006; 129
Wang (R141-20250630) 2025; 29
Zhang (R167-20250630) 2022; 20
Daneman (R23-20250630) 2010; 468
References_xml – volume: 15
  start-page: 1227
  year: 2024
  ident: R143-20250630
  article-title: Astrocyte-derived extracellular vesicles for ischemic stroke: therapeutic potential and prospective
  publication-title: Aging Dis
– volume: 17
  start-page: 1125412
  year: 2023
  ident: R38-20250630
  article-title: Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes
  publication-title: Front Cell Neurosci
  doi: 10.3389/fncel.2023.1125412
– volume: 267
  start-page: 135
  year: 2014
  ident: R93-20250630
  article-title: Ectopic expression of human angiopoietin-1 promotes functional recovery and neurogenesis after focal cerebral ischemia
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2014.02.036
– volume: 21
  start-page: 101059
  year: 2019
  ident: R123-20250630
  article-title: NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2018.11.017
– volume: 29
  start-page: 6317
  year: 2025
  ident: R141-20250630
  article-title: Systematic review of machine learning models for predicting functional recovery and prognosis in stroke
  publication-title: Zhongguo Zuzhi Gongchneg Yanjiu
– volume: 532
  start-page: 195
  year: 2016
  ident: R4-20250630
  article-title: Astrocyte scar formation aids central nervous system axon regeneration
  publication-title: Nature
  doi: 10.1038/nature17623
– volume: 580
  start-page: 937
  year: 2007
  ident: R41-20250630
  article-title: Dexamethasone induces the expression of metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND
  publication-title: J Physiol
  doi: 10.1113/jphysiol.2007.129007
– volume: 11
  start-page: 703
  year: 2020
  ident: R79-20250630
  article-title: The multifaceted role of astrocyte connexin 43 in ischemic stroke through forming hemichannels and gap junctions
  publication-title: Front Neurol
  doi: 10.3389/fneur.2020.00703
– volume: 40
  start-page: 7355
  year: 2020
  ident: R90-20250630
  article-title: Neuron-derived estrogen is critical for astrocyte activation and neuroprotection of the ischemic brain
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0115-20.2020
– volume: 55
  start-page: 2402
  year: 2023
  ident: R24-20250630
  article-title: HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain
  publication-title: Exp Mol Med
  doi: 10.1038/s12276-023-01111-z
– volume: 13
  start-page: 943
  year: 2022
  ident: R169-20250630
  article-title: Blocking C3d(+)/GFAP(+) A1 astrocyte conversion with semaglutide attenuates blood-brain barrier disruption in mice after ischemic stroke
  publication-title: Aging Dis
  doi: 10.14336/AD.2021.1029
– volume: 46
  start-page: 236
  year: 2012
  ident: R164-20250630
  article-title: Recombinant human angiopoietin-1 ameliorates the expressions of ZO-1, occludin, VE-cadherin, and PKCα signaling after focal cerebral ischemia/reperfusion in rats
  publication-title: J Mol Neurosci: MN
  doi: 10.1007/s12031-011-9584-5
– volume: 11
  start-page: 1024
  year: 2020
  ident: R86-20250630
  article-title: Interaction of microglia and astrocytes in the neurovascular unit
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.01024
– volume: 19
  start-page: 771
  year: 2016
  ident: R129-20250630
  article-title: Pericytes of the neurovascular unit: key functions and signaling pathways
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4288
– volume: 217
  start-page: 116
  year: 2024
  ident: R154-20250630
  article-title: Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2024.03.019
– volume: 6
  start-page: 113
  year: 2020
  ident: R171-20250630
  article-title: Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice
  publication-title: Cell Death Discov
  doi: 10.1038/s41420-020-00346-3
– volume: 39
  start-page: 301
  year: 2019
  ident: R91-20250630
  article-title: Myosin IIA regulated tight junction in oxygen glucose-deprived brain endothelial cells via activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 signal transduction pathway
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/s10571-019-00654-y
– volume: 40
  start-page: 1849
  year: 2009
  ident: R47-20250630
  article-title: Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.534503
– volume: 112
  start-page: 170
  year: 2003
  ident: R92-20250630
  article-title: Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain
  publication-title: Brain Res Mol Brain Res
  doi: 10.1016/S0169-328X(03)00088-3
– volume: 313
  start-page: 116597
  year: 2023
  ident: R148-20250630
  article-title: The combination of Alisma and Atractylodes ameliorates cerebral ischaemia/reperfusion injury by negatively regulating astrocyte-derived exosomal miR-200a-3p/141-3p by targeting SIRT1
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2023.116597
– volume: 168
  start-page: 1877
  year: 2024
  ident: R118-20250630
  article-title: MMP-2-mediated Scube2 degradation promotes blood-brain barrier disruption by blocking the interaction between astrocytes and endothelial cells via inhibiting Sonic hedgehog pathway during early cerebral ischemia
  publication-title: J Neurochem
  doi: 10.1111/jnc.16021
– volume: 16
  start-page: ao41354
  year: 2024
  ident: R95-20250630
  article-title: Astrocyte regulation of cerebral blood flow in health and disease
  publication-title: Cold Spring Harb Perspect Biol
– volume: 12
  start-page: 666790
  year: 2021
  ident: R163-20250630
  article-title: Synergic neuroprotection between ligusticum chuanxiong hort and borneol against ischemic stroke by neurogenesis via modulating reactive astrogliosis and maintaining the blood-brain barrier
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2021.666790
– volume: 13
  start-page: 1088
  year: 2006
  ident: R31-20250630
  article-title: FGF-2 overexpression opposes the beta amyloid toxic injuries to the vascular endothelium
  publication-title: Cell Death Differ
  doi: 10.1038/sj.cdd.4401803
– volume: 129
  start-page: 2761
  year: 2006
  ident: R98-20250630
  article-title: Essential protective roles of reactive astrocytes in traumatic brain injury
  publication-title: Brain
  doi: 10.1093/brain/awl165
– volume: 113
  start-page: 1771
  year: 2000
  ident: R100-20250630
  article-title: Tight junctions are membrane microdomains
  publication-title: J Cell Sci
  doi: 10.1242/jcs.113.10.1771
– volume: 19
  start-page: 1637
  year: 2015
  ident: R139-20250630
  article-title: Lipocalin-2 released in response to cerebral ischaemia mediates reperfusion injury in mice
  publication-title: J Cell MolMed
– volume: 12
  start-page: 15
  year: 2015
  ident: R109-20250630
  article-title: Pentraxin 3 mediates neurogenesis and angiogenesis after cerebral ischaemia
  publication-title: J Neuroinflammation
  doi: 10.1186/s12974-014-0227-y
– volume: 24
  start-page: 435
  year: 2004
  ident: R26-20250630
  article-title: Expression, regulation, and function of IGF-1, IGF–1R, and IGF-1 binding proteins in blood vessels
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000105902.89459.09
– volume: 55
  start-page: 279
  year: 2007
  ident: R34-20250630
  article-title: The effect of moderate hypothermia in acute ischemic stroke on pericyte migration: an ultrastructural study
  publication-title: Cryobiology
  doi: 10.1016/j.cryobiol.2007.08.009
– volume: 19
  start-page: 1584
  year: 2013
  ident: R101-20250630
  article-title: Development, maintenance and disruption of the blood-brain barrier
  publication-title: Nat Med
  doi: 10.1038/nm.3407
– volume: 20
  start-page: 9
  year: 2022
  ident: R167-20250630
  article-title: Exosomes: the key of sophisticated cell-cell communication and targeted metastasis in pancreatic cancer
  publication-title: J Cell Commun Signal
  doi: 10.1186/s12964-021-00808-w
– volume: 63
  start-page: 70
  year: 2002
  ident: R39-20250630
  article-title: Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1
  publication-title: Microvas Res
  doi: 10.1006/mvre.2001.2367
– volume: 46
  start-page: 957
  year: 2017
  ident: R82-20250630
  article-title: Reactive astrocytes: production, function, and therapeutic potential
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.06.006
– volume: 19
  start-page: 168
  year: 2022
  ident: R85-20250630
  article-title: Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity
  publication-title: J Neuroinflamm
  doi: 10.1186/s12974-022-02533-8
– volume: 28
  start-page: e70004
  year: 2024
  ident: R144-20250630
  article-title: A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.70004
– volume: 70
  start-page: 975
  year: 2022
  ident: R77-20250630
  article-title: Longitudinal intravital imaging of cerebral microinfarction reveals a dynamic astrocyte reaction leading to glial scar formation
  publication-title: Glia
  doi: 10.1002/glia.24151
– volume: 20
  start-page: 1277
  year: 2025
  ident: R178-20250630
  article-title: T cell interactions with microglia in immune-inflammatory processes of ischemic stroke
  publication-title: Neural Regen Res
  doi: 10.4103/NRR.NRR-D-23-01385
– volume: 31
  start-page: 791
  year: 2020
  ident: R53-20250630
  article-title: Mitochondria-endoplasmic reticulum contacts in reactive astrocytes promote vascular remodeling
  publication-title: Cell metab
  doi: 10.1016/j.cmet.2020.03.005
– volume: 22
  start-page: 1892
  year: 2019
  ident: R97-20250630
  article-title: Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module
  publication-title: Nat Neurosci
  doi: 10.1038/s41593-019-0497-x
– volume: 112
  start-page: 9914
  year: 2015
  ident: R149-20250630
  article-title: Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1509047112
– volume: 81
  start-page: 229
  year: 2014
  ident: R11-20250630
  article-title: Reactive gliosis and the multicellular response to CNS damage and disease
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.12.034
– volume: 314
  start-page: 122868
  year: 2025
  ident: R78-20250630
  article-title: Metal-organic framework-edaravone nanoparticles for radiotherapy-induced brain injury treatment
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2024.122868
– volume: 144
  start-page: 103
  year: 2016
  ident: R89-20250630
  article-title: Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2015.09.008
– volume: 317
  start-page: 123102
  year: 2025
  ident: R155-20250630
  article-title: Regulating astrocyte phenotype by Lcn2 inhibition toward ischemic stroke therapy
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2025.123102
– volume: 13
  start-page: 751304
  year: 2021
  ident: R54-20250630
  article-title: Insulin-like growth factor-1 differentially modulates glutamate-induced toxicity and stress in cells of the neurogliovascular unit
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2021.751304
– volume: 60
  start-page: 1646
  year: 2012
  ident: R126-20250630
  article-title: Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation
  publication-title: Glia
  doi: 10.1002/glia.22383
– volume: 55
  start-page: 1145
  year: 2007
  ident: R51-20250630
  article-title: Transcriptional regulation of scar gene expression in primary astrocytes
  publication-title: Glia
  doi: 10.1002/glia.20537
– volume: 149
  start-page: 231
  year: 2019
  ident: R65-20250630
  article-title: miR-124 upregulates astrocytic glutamate transporter-1 via the Akt and mTOR signaling pathway post ischemic stroke
  publication-title: Brain Res Bull
  doi: 10.1016/j.brainresbull.2019.04.013
– volume: 68
  start-page: 101335
  year: 2021
  ident: R106-20250630
  article-title: Reactive astrocytes: the nexus of pathological and clinical hallmarks of Alzheimer’s disease
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2021.101335
– volume: 19
  start-page: 100886
  year: 2024
  ident: R173-20250630
  article-title: Edaravone-loaded poly amino acid) nanogel inhibits ferroptosis for neuroprotection in cerebral ischemia injury
  publication-title: Asian J Pharm Sci
– volume: 21
  start-page: 195
  year: 2001
  ident: R33-20250630
  article-title: Dynamic imaging of cerebral blood flow using laser speckle
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1097/00004647-200103000-00002
– volume: 278
  start-page: 43329
  year: 2003
  ident: R28-20250630
  article-title: Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M305835200
– volume: 36
  start-page: 7727
  year: 2016
  ident: R133-20250630
  article-title: Glutamate-mediated blood-brain barrier opening: implications for neuroprotection and drug delivery
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0587-16.2016
– volume: 46
  start-page: 827
  year: 2015
  ident: R22-20250630
  article-title: Deficiency of brain ATP-binding cassette transporter A-1 exacerbates blood-brain barrier and white matter damage after stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.114.007145
– volume: 586
  start-page: 1937
  year: 2008
  ident: R42-20250630
  article-title: Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier
  publication-title: J Physiol
  doi: 10.1113/jphysiol.2007.146852
– volume: 37
  start-page: 608
  year: 2016
  ident: R20-20250630
  article-title: Astrocytes: key regulators of neuroinflammation
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2016.06.006
– volume: 135
  start-page: 311
  year: 2018
  ident: R83-20250630
  article-title: Functional morphology of the blood-brain barrier in health and disease
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-018-1815-1
– volume: 83
  start-page: 1231
  year: 2006
  ident: R108-20250630
  article-title: Time course of aquaporin expression after transient focal cerebral ischemia in mice
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.20819
– volume: 361
  start-page: eaao2861
  year: 2018
  ident: R115-20250630
  article-title: Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system
  publication-title: Science
  doi: 10.1126/science.aao2861
– volume: 295
  start-page: R864
  year: 2008
  ident: R113-20250630
  article-title: Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation
  publication-title: Am J Physiol Regul Integr Comp Physiol
  doi: 10.1152/ajpregu.00536.2007
– volume: 468
  start-page: 562
  year: 2010
  ident: R23-20250630
  article-title: Pericytes are required for blood-brain barrier integrity during embryogenesis
  publication-title: Nature
  doi: 10.1038/nature09513
– volume: 13
  start-page: 647
  year: 2022
  ident: R64-20250630
  article-title: VEGF, a key factor for blood brain barrier injury after cerebral ischemic stroke
  publication-title: Aging Dis
  doi: 10.14336/AD.2021.1121
– volume: 38
  start-page: 2563
  year: 2007
  ident: R75-20250630
  article-title: Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.106.481515
– volume: 13
  start-page: 667
  year: 2022
  ident: R162-20250630
  article-title: Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-022-05043-w
– volume: 127
  start-page: 110125
  year: 2020
  ident: R142-20250630
  article-title: Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2020.110125
– volume: 25
  start-page: 1658
  year: 1994
  ident: R158-20250630
  article-title: Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats
  publication-title: Stroke
  doi: 10.1161/01.STR.25.8.1658
– volume: 47
  start-page: 1094
  year: 2016
  ident: R120-20250630
  article-title: Astrocyte-derived pentraxin 3 supports blood-brain barrier integrity under acute phase of stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.115.012133
– volume: 468
  start-page: 557
  year: 2010
  ident: R5-20250630
  article-title: Pericytes regulate the blood-brain barrier
  publication-title: Nature
  doi: 10.1038/nature09522
– volume: 273
  start-page: 29745
  year: 1998
  ident: R36-20250630
  article-title: The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.45.29745
– volume: 8
  start-page: 1223
  year: 2006
  ident: R46-20250630
  article-title: VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1486
– volume: 17
  start-page: 101
  year: 2020
  ident: R68-20250630
  article-title: Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model
  publication-title: J Neuroinflammation
  doi: 10.1186/s12974-020-01784-7
– volume: 16
  start-page: 3919
  year: 2005
  ident: R117-20250630
  article-title: Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e04-12-1089
– volume: 4
  start-page: 78
  year: 2019
  ident: R157-20250630
  article-title: Basement membrane and blood-brain barrier
  publication-title: Stroke Vasc Neurol
  doi: 10.1136/svn-2018-000198
– volume: 12
  start-page: 441
  year: 2006
  ident: R174-20250630
  article-title: Role of matrix metalloproteinases in delayed cortical responses after stroke
  publication-title: Nat Med
  doi: 10.1038/nm1387
– volume: 334
  start-page: 1727
  year: 2011
  ident: R2-20250630
  article-title: The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
  publication-title: Science
  doi: 10.1126/science.1206936
– volume: 327
  start-page: 885
  year: 2022
  ident: R135-20250630
  article-title: What is acute ischemic stroke?
  publication-title: JAMA
  doi: 10.1001/jama.2022.1420
– volume: 46
  start-page: 237
  year: 2015
  ident: R16-20250630
  article-title: Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.114.007445
– volume: 7
  start-page: 10523
  year: 2016
  ident: R119-20250630
  article-title: Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury
  publication-title: Nat Commun
  doi: 10.1038/ncomms10523
– volume: 62
  start-page: 1895
  year: 2014
  ident: R107-20250630
  article-title: Glial scar and immune cell involvement in tissue remodeling and repair following acute CNS injuries
  publication-title: Glia
  doi: 10.1002/glia.22676
– volume: 34
  start-page: 480
  year: 2014
  ident: R110-20250630
  article-title: The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2013.224
– volume: 15
  start-page: 2318
  year: 2020
  ident: R179-20250630
  article-title: Pentraxin 3 contributes to neurogenesis after traumatic brain injury in mice
  publication-title: Neural Regen Res
  doi: 10.4103/1673-5374.285001
– volume: 30
  start-page: 2044
  year: 2016
  ident: R99-20250630
  article-title: THC (Δ9–Tetrahydrocannabinol) exerts neuroprotective effect in glutamate-affected murine primary mesencephalic cultures through restoring mitochondrial membrane potential and anti-apoptosis involving CB(1) receptor-dependent mechanism
  publication-title: Phytother Res
  doi: 10.1002/ptr.5712
– volume: 11
  start-page: 573256
  year: 2020
  ident: R84-20250630
  article-title: Protective functions of reactive astrocytes following central nervous system insult
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.573256
– volume: 21
  start-page: 452
  year: 2023
  ident: R44-20250630
  article-title: Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway
  publication-title: J Nanobiotechnol
  doi: 10.1186/s12951-023-02110-y
– volume: 55
  start-page: 214
  year: 2007
  ident: R61-20250630
  article-title: TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling
  publication-title: Glia
  doi: 10.1002/glia.20453
– volume: 28
  start-page: 564
  year: 1997
  ident: R72-20250630
  article-title: A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans
  publication-title: Stroke
  doi: 10.1161/01.STR.28.3.564
– volume: 8
  start-page: e68891
  year: 2013
  ident: R153-20250630
  article-title: Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0068891
– volume: 30
  start-page: 837
  year: 2010
  ident: R8-20250630
  article-title: Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2009.248
– volume: 68
  start-page: 86
  year: 2016
  ident: R111-20250630
  article-title: Sonic Hedgehog regulates thymic epithelial cell differentiation
  publication-title: J Autoimmun
  doi: 10.1016/j.jaut.2015.12.004
– volume: 38
  start-page: 748
  year: 2007
  ident: R175-20250630
  article-title: Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke
  publication-title: Stroke
  doi: 10.1161/01.STR.0000253500.32979.d1
– volume: 115
  start-page: E1896
  year: 2018
  ident: R18-20250630
  article-title: Normal aging induces A1-like astrocyte reactivity
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1800165115
– volume: 26
  start-page: 797
  year: 2006
  ident: R29-20250630
  article-title: Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/sj.jcbfm.9600229
– volume: 56
  start-page: 4653
  year: 2019
  ident: R30-20250630
  article-title: Astrocytes and the TGF-β1 pathway in the healthy and diseased brain: a double-edged sword
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-018-1396-y
– volume: 565
  start-page: 30
  year: 2014
  ident: R103-20250630
  article-title: The dual role of astrocyte activation and reactive gliosis
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2013.12.071
– volume: 10
  start-page: 487
  year: 2019
  ident: R13-20250630
  article-title: Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1716-9
– volume: 29
  start-page: 81
  year: 1995
  ident: R9-20250630
  article-title: Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain
  publication-title: Brain Res Mol Brain Res
  doi: 10.1016/0169-328X(94)00232-4
– volume: 280
  start-page: 119715
  year: 2021
  ident: R165-20250630
  article-title: Resveratrol-mediated neurorestoration after cerebral ischemic injury -Sonic Hedgehog signaling pathway
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2021.119715
– volume: 2022
  start-page: 3855698
  year: 2022
  ident: R66-20250630
  article-title: Edaravone dexborneol downregulates neutrophil extracellular trap expression and ameliorates blood-brain barrier permeability in acute ischemic stroke
  publication-title: Mediat Inflamm
  doi: 10.1155/2022/3855698
– volume: 9
  start-page: 643
  year: 2020
  ident: R137-20250630
  article-title: HMGB1 translocation in neurons after ischemic insult: subcellular localization in mitochondria and peroxisomes
  publication-title: Cells
  doi: 10.3390/cells9030643
– volume: 163-164
  start-page: 144
  year: 2018
  ident: R67-20250630
  article-title: Blood-brain barrier dysfunction and recovery after ischemic stroke
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2017.10.001
– volume: 1
  start-page: 457
  year: 1999
  ident: R49-20250630
  article-title: Selective transfer of endogenous metabolites through gap junctions composed of different connexins
  publication-title: Nat Cell Biol
  doi: 10.1038/15693
– volume: 120
  start-page: 449
  year: 2017
  ident: R63-20250630
  article-title: Cerebral vascular disease and neurovascular injury in ischemic stroke
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.116.308427
– volume: 364
  start-page: 473
  year: 2023
  ident: R6-20250630
  article-title: Astrocytes and microglia-targeted Danshensu liposomes enhance the therapeutic effects on cerebral ischemia-reperfusion injury
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2023.11.002
– volume: 69
  start-page: 281
  year: 2021
  ident: R52-20250630
  article-title: Astroglial N-myc downstream-regulated gene 2 protects the brain from cerebral edema induced by stroke
  publication-title: Glia
  doi: 10.1002/glia.23888
– volume: 98
  start-page: 239
  year: 2018
  ident: R134-20250630
  article-title: Physiology of astroglia
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00042.2016
– year: 2023
  ident: R55-20250630
  article-title: Neuronal and astrocyte insulin-like growth factor-1 signaling differentially modulates ischemic stroke damage
  publication-title: bioRxiv
– volume: 541
  start-page: 481
  year: 2017
  ident: R81-20250630
  article-title: Neurotoxic reactive astrocytes are induced by activated microglia
  publication-title: Nature
  doi: 10.1038/nature21029
– volume: 21
  year: 2020
  ident: R140-20250630
  article-title: Neutralization of lipocalin-2 diminishes stroke-reperfusion injury
  publication-title: Int J Mol Sci
– volume: 26
  start-page: 4729
  year: 2006
  ident: R131-20250630
  article-title: Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3900-05.2006
– volume: 64
  start-page: 116
  year: 2002
  ident: R50-20250630
  article-title: Early pericyte response to brain hypoxia in cats: an ultrastructural study
  publication-title: Microvas Res
  doi: 10.1006/mvre.2002.2413
– volume: 4
  start-page: 991
  year: 2003
  ident: R3-20250630
  article-title: The molecular basis of water transport in the brain
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn1252
– volume: 82
  start-page: 603
  year: 2014
  ident: R70-20250630
  article-title: Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.03.003
– volume: 21
  start-page: 2465
  year: 2023
  ident: R80-20250630
  article-title: The relationship of astrocytes and microglia with different stages of ischemic stroke
  publication-title: Curr Neuropharmacol
  doi: 10.2174/1570159X21666230718104634
– volume: 43
  start-page: e230
  year: 2015
  ident: R48-20250630
  article-title: Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis
  publication-title: Crit Care Med
  doi: 10.1097/CCM.0000000000000993
– volume: 180
  start-page: 117
  year: 2018
  ident: R12-20250630
  article-title: 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.07.014
– volume: 19
  start-page: e13236
  year: 2020
  ident: R14-20250630
  article-title: miR-195 reduces age-related blood-brain barrier leakage caused by thrombospondin-1-mediated selective autophagy
  publication-title: Aging Cell
  doi: 10.1111/acel.13236
– volume: 24
  start-page: 823
  year: 2021
  ident: R132-20250630
  article-title: Pericyte hypoxia-inducible factor-1 (HIF-1) drives blood-brain barrier disruption and impacts acute ischemic stroke outcome
  publication-title: Angiogenesis
  doi: 10.1007/s10456-021-09796-4
– volume: 542
  start-page: 81
  year: 2013
  ident: R156-20250630
  article-title: Multipotent mesenchymal stromal cells decrease transforming growth factor β1 expression in microglia/macrophages and down-regulate plasminogen activator inhibitor 1 expression in astrocytes after stroke
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2013.02.046
– volume: 33
  start-page: 30
  year: 2013
  ident: R19-20250630
  article-title: NG2 and NG2-positive cells delineate focal cerebral infarct demarcation in rats
  publication-title: Neuropathology
  doi: 10.1111/j.1440-1789.2012.01322.x
– volume: 33
  start-page: 12870
  year: 2013
  ident: R146-20250630
  article-title: Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2121-13.2013
– volume: 14
  start-page: 594170
  year: 2020
  ident: R168-20250630
  article-title: Development of neuroregenerative gene therapy to reverse glial scar tissue back to neuron-enriched tissue
  publication-title: Front Cell Neurosci
  doi: 10.3389/fncel.2020.594170
– volume: 336
  start-page: 633
  year: 1997
  ident: R74-20250630
  article-title: Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors
  publication-title: N Eng J Med
  doi: 10.1056/NEJM199702273360907
– volume: 35
  start-page: 292
  year: 2015
  ident: R71-20250630
  article-title: Blood-brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2014.199
– volume: 128
  start-page: 155530
  year: 2024
  ident: R170-20250630
  article-title: Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2024.155530
– volume: 44
  start-page: 318
  year: 2022
  ident: R176-20250630
  article-title: The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats
  publication-title: Neurol res
  doi: 10.1080/01616412.2021.1981106
– volume: 24
  start-page: 1228
  year: 2024
  ident: R37-20250630
  article-title: Ferroptosis is involved in the pharmacological effect of ginsenoside
  publication-title: Mini Rev Med Chem
  doi: 10.2174/0113895575277359231210145922
– volume: 33
  start-page: 3315
  year: 1984
  ident: R116-20250630
  article-title: Comparison of the prostanoid synthesizing capacity in homogenates from primary neuronal and astroglial cell cultures
  publication-title: Biochem Pharmacol
  doi: 10.1016/0006-2952(84)90099-6
– volume: 35
  start-page: 109048
  year: 2021
  ident: R150-20250630
  article-title: Reactive astrocytes facilitate vascular repair and remodeling after stroke
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2021.109048
– volume: 59
  start-page: 119
  year: 1998
  ident: R10-20250630
  article-title: Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury
  publication-title: Brain Res Mol Brain Res
  doi: 10.1016/S0169-328X(98)00122-3
– volume: 144
  start-page: 158
  year: 2016
  ident: R128-20250630
  article-title: Lipocalin-2 as a therapeutic target for brain injury: an astrocentric perspective
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2016.08.001
– volume: 180
  start-page: 308
  year: 2023
  ident: R43-20250630
  article-title: Icariside II preconditioning evokes robust neuroprotection against ischaemic stroke, by targeting Nrf2 and the OXPHOS/NF-κB/ferroptosis pathway
  publication-title: Brit pharmacol
  doi: 10.1111/bph.15961
– volume: 115
  start-page: 635
  year: 2008
  ident: R161-20250630
  article-title: Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-008-0364-4
– volume: 199
  start-page: 101963
  year: 2021
  ident: R124-20250630
  article-title: Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2020.101963
– volume: 41
  start-page: 1203
  year: 2021
  ident: R159-20250630
  article-title: Sirt3 protects against ischemic stroke injury by regulating HIF-1α/VEGF signaling and blood-brain barrier integrity
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/s10571-020-00889-0
– volume: 20
  start-page: 503
  year: 2025
  ident: R87-20250630
  article-title: A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury
  publication-title: Neural Regen Res
  doi: 10.4103/NRR.NRR-D-23-01322
– volume: 75
  start-page: 815
  year: 2023
  ident: R114-20250630
  article-title: ABCB1 and ABCG2 regulation at the blood-brain barrier: potential new targets to improve brain drug delivery
  publication-title: Pharmacol Rev
  doi: 10.1124/pharmrev.120.000025
– volume: 21
  start-page: 354
  year: 2015
  ident: R105-20250630
  article-title: Sphingosine 1-phosphate signaling at the blood-brain barrier
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2015.03.006
– volume: 2011
  start-page: 823525
  year: 2011
  ident: R104-20250630
  article-title: Regulation of cerebral blood flow
  publication-title: Int J Vasc Med
– volume: 13
  start-page: 1045
  year: 2014
  ident: R147-20250630
  article-title: The role of iron in brain ageing and neurodegenerative disorders
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(14)70117-6
– volume: 1367
  start-page: 347
  year: 2011
  ident: R62-20250630
  article-title: Lentivirus-mediated transfer of MMP-9 shRNA provides neuroprotection following focal ischemic brain injury in rats
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2010.10.002
– volume: 335
  start-page: 27
  year: 2009
  ident: R122-20250630
  article-title: Endothelial transcytosis in health and disease
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-008-0688-3
– volume: 16
  start-page: 168
  year: 2019
  ident: R177-20250630
  article-title: Lipocalin-2 may produce damaging effect after cerebral ischemia by inducing astrocytes classical activation
  publication-title: J Neuroinflamm
  doi: 10.1186/s12974-019-1556-7
– volume: 15
  start-page: 818
  year: 2024
  ident: R17-20250630
  article-title: Brain-targeting emodin mitigates ischemic stroke via inhibiting AQP4-mediated swelling and neuroinflammation
  publication-title: Transl Stroke Res
  doi: 10.1007/s12975-023-01170-4
– volume: 144
  start-page: 305
  year: 2022
  ident: R125-20250630
  article-title: Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-022-02452-1
– volume: 10
  start-page: 923
  year: 2008
  ident: R130-20250630
  article-title: Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1752
– volume: 20
  start-page: 133
  year: 1983
  ident: R136-20250630
  article-title: Functional interactions between neurons and astrocytes. II. Potassium homeostasis at the cellular level
  publication-title: Prog Neurobiol
  doi: 10.1016/0301-0082(83)90013-8
– volume: 11
  start-page: 4351
  year: 2021
  ident: R27-20250630
  article-title: Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity
  publication-title: Theranostics
  doi: 10.7150/thno.52436
– volume: 17
  start-page: 1072
  year: 2022
  ident: R166-20250630
  article-title: M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury
  publication-title: Neural Regen Res
  doi: 10.4103/1673-5374.324858
– volume: 12
  start-page: 372
  year: 2018
  ident: R15-20250630
  article-title: Inhibition of connexin 43 hemichannels alleviates cerebral ischemia/reperfusion injury via the TLR4 signaling pathway
  publication-title: Front Cell Neurosci
  doi: 10.3389/fncel.2018.00372
– volume: 142
  start-page: 623
  year: 1993
  ident: R45-20250630
  article-title: Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat
  publication-title: Am J Pathol
– volume: 20
  start-page: 2758
  year: 2025
  ident: R88-20250630
  article-title: PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives
  publication-title: Neural Regen Res
  doi: 10.4103/NRR.NRR-D-24-00568
– volume: 82
  start-page: 863
  year: 2002
  ident: R58-20250630
  article-title: Photocoagulation-induced retinal gliosis is inhibited by systemically expressed soluble TGF-beta receptor type II via adenovirus mediated gene transfer
  publication-title: Lab Invest
  doi: 10.1097/01.LAB.0000018829.49754.DD
– volume: 12
  start-page: e2410889
  year: 2025
  ident: R145-20250630
  article-title: Traditional chinese medicine borneol-based polymeric micelles intracerebral drug delivery system for precisely pathogenesis-adaptive treatment of ischemic stroke
  publication-title: Adv Sci (Weinh)
  doi: 10.1002/advs.202410889
– volume: 78
  start-page: 105
  year: 2024
  ident: R73-20250630
  article-title: The impact of cytokines in neuroinflammation-mediated stroke
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2024.06.002
– volume: 14
  start-page: 731
  year: 2008
  ident: R127-20250630
  article-title: Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
  publication-title: Nat Med
  doi: 10.1038/nm1787
– volume: 101
  start-page: e502
  year: 2023
  ident: R7-20250630
  article-title: Blood-brain barrier permeability and kinetics of inflammatory markers in acute stroke patients treated with thrombectomy
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000207460
– volume: 44
  start-page: 3275
  year: 2013
  ident: R40-20250630
  article-title: Brain regulation of thrombosis and hemostasis: from theory to practice
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.113.000736
– volume: 8
  start-page: 28
  year: 2017
  ident: R96-20250630
  article-title: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-00037-1
– volume: 9
  start-page: 518
  year: 2018
  ident: R172-20250630
  article-title: Ginkgo biloba extract inhibits astrocytic lipocalin-2 expression and alleviates neuroinflammatory injury via the JAK2/STAT3 pathway after ischemic brain stroke
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2018.00518
– volume: 34
  start-page: 108829
  year: 2021
  ident: R102-20250630
  article-title: Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2021.108829
– volume: 61
  start-page: 972
  year: 2013
  ident: R21-20250630
  article-title: Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix
  publication-title: Glia
  doi: 10.1002/glia.22489
– volume: 148
  start-page: 105080
  year: 2021
  ident: R35-20250630
  article-title: A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils?
  publication-title: Neurochem Int
  doi: 10.1016/j.neuint.2021.105080
– volume: 497
  start-page: 116
  year: 2011
  ident: R112-20250630
  article-title: Cerebral capillary endothelial cells are covered by the VEGF-expressing foot processes of astrocytes
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2011.04.043
– volume: 14
  start-page: 830569
  year: 2022
  ident: R138-20250630
  article-title: Iron dyshomeostasis and ferroptosis: a new alzheimer’s disease hypothesis?
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2022.830569
– volume: 38
  start-page: e23827
  year: 2024
  ident: R151-20250630
  article-title: NDRG2 regulates glucose metabolism and ferroptosis of OGD/R-treated astrocytes by the Wnt/β-catenin signaling
  publication-title: J Biochem Mol Toxic
  doi: 10.1002/jbt.23827
– volume: 456
  start-page: 605
  year: 2008
  ident: R25-20250630
  article-title: Mitofusin 2 tethers endoplasmic reticulum to mitochondria
  publication-title: Nature
  doi: 10.1038/nature07534
– volume: 36
  start-page: 928
  year: 2015
  ident: R152-20250630
  article-title: Connexin 43 stabilizes astrocytes in a stroke-like milieu to facilitate neuronal recovery
  publication-title: Acta Pharmacol Sin
  doi: 10.1038/aps.2015.39
– volume: 49
  start-page: 1479
  year: 2018
  ident: R59-20250630
  article-title: Early blood-brain barrier disruption in ischemic stroke initiates multifocally around capillaries/venules
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.118.020927
– volume: 35
  start-page: 433
  year: 2021
  ident: R32-20250630
  article-title: NRF2 and hypoxia-inducible factors: key players in the redox control of systemic iron homeostasis
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2020.8148
– volume: 152
  start-page: 391
  year: 1998
  ident: R94-20250630
  article-title: Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice
  publication-title: Am J Pathol
– volume: 42
  start-page: 3323
  year: 2011
  ident: R160-20250630
  article-title: Blood-brain barrier breakdown in acute and chronic cerebrovascular disease
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.110.608257
– volume: 19
  start-page: 624
  year: 1999
  ident: R56-20250630
  article-title: Matrix metalloproteinases increase very early during experimental focal cerebral ischemia
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1097/00004647-199906000-00005
– volume: 65
  start-page: 1471
  year: 2017
  ident: R69-20250630
  article-title: Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia
  publication-title: Glia
  doi: 10.1002/glia.23174
– volume: 7
  start-page: 41
  year: 2006
  ident: R1-20250630
  article-title: Astrocyte-endothelial interactions at the blood-brain barrier
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn1824
– volume: 22
  start-page: 587
  year: 2010
  ident: R57-20250630
  article-title: Changes in DNA repair enzymes in rat ventroposterior nucleus of the thalamus after cerebral cortex infarction
  publication-title: Crit Care Med
– volume: 21
  start-page: 8
  year: 2024
  ident: R60-20250630
  article-title: Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/β-catenin axis
  publication-title: Fluids Barriers CNS
  doi: 10.1186/s12987-024-00510-2
– volume: 425
  start-page: 103
  year: 2017
  ident: R121-20250630
  article-title: Orexin-A promotes Glu uptake by OX1R/PKCα/ERK1/2/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia/hypoglycemic injury in vitro
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-016-2866-z
– volume: 21
  start-page: 339
  year: 2022
  ident: R76-20250630
  article-title: Function and therapeutic value of astrocytes in neurological diseases
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/s41573-022-00390-x
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Snippet Ischemic stroke, a frequently occurring form of stroke, is caused by obstruction of cerebral blood flow, which leads to ischemia, hypoxia, and necrosis of...
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SubjectTerms astrocytes
axon
Blood-brain barrier
cytokines
endothelial cells
glial scar
Growth factors
Ischemia
ischemic stroke
Morphology
phenotype
remodel
Review
vascular
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Title Different roles of astrocytes in the blood-brain barrier during the acute and recovery phases of stroke
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