PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

Cachexia is frequently accompanied by severe metabolic derangements, although the mechanisms responsible for this debilitating condition remain unclear. Pyruvate dehydrogenase kinase (PDK)4, a critical regulator of cellular energetic metabolism, was found elevated in experimental models of cancer, s...

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Bibliographic Details

Published in:	The FASEB journal Vol. 33; no. 6; p. 7778
Main Authors:	Pin, Fabrizio, Novinger, Leah J, Huot, Joshua R, Harris, Robert A, Couch, Marion E, O'Connell, Thomas M, Bonetto, Andrea
Format:	Journal Article
Language:	English
Published:	United States 01.06.2019
Subjects:	C2C12 myotubes skeletal muscle atrophy chemotherapy mitochondria energy metabolism
ISSN:	1530-6860, 1530-6860
Online Access:	Get more information
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