Research Progress on the Pathogenesis of Knee Osteoarthritis

Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties and pain, severe cases can lead to limb paralysis, which poses major pressure to the quality of life and mental heal...

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Published in:Orthopaedic surgery Vol. 15; no. 9; pp. 2213 - 2224
Main Authors: Du, Xin, Liu, Zi‐yu, Tao, Xing‐xing, Mei, Yong‐liang, Zhou, Da‐qian, Cheng, Kang, Gao, Si‐long, Shi, Hou‐yin, Song, Chao, Zhang, Xiao‐min
Format: Journal Article
Language:English
Published: Melbourne John Wiley & Sons Australia, Ltd 01.09.2023
John Wiley & Sons, Inc
Wiley
Subjects:
Aging
Arthritis
Biomechanics
Body mass index
Bone Metabolism
Cartilage
Cytokines
Hypertension
Inflammation
Knee
Knee Osteoarthritis
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Long Non‐Coding RNA
Metabolic syndrome
Obesity
Osteoarthritis
Pathogenesis
Review
Risk factors
Trauma
Weight control
Knee Osteoarthritis
Inflammation
Cytokines
Long Non-Coding RNA
Bone Metabolism
ISSN:1757-7853, 1757-7861, 1757-7861
Online Access:Get full text
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Summary:Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties and pain, severe cases can lead to limb paralysis, which poses major pressure to the quality of life and mental health of patients, but also brings serious economic burden to society. The occurrence and development of KOA is influenced by many factors, including systemic factors and local factors. The joint biomechanical changes caused by aging, trauma and obesity, abnormal bone metabolism caused by metabolic syndrome, the effects of cytokines and related enzymes, genetic and biochemical abnormalities caused by plasma adiponectin, etc. all directly or indirectly lead to the occurrence of KOA. However, there is little literature that systematically and comprehensively integrates macro‐ and microscopic KOA pathogenesis. Therefore, it is necessary to comprehensively and systematically summarize the pathogenesis of KOA in order to provide a better theoretical basis for clinical treatment. Macroscopic factors affecting the occurrence and development of knee osteoarthritis.
Bibliography:Xin Du, Zi‐yu Liu these authors contributed to the work equally and should be regarded as co‐first authors.
Chao Song, Xiao‐min Zhang these authors contributed to the work equally and should be regarded as co‐corresponding authors.
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ISSN:1757-7853
1757-7861
1757-7861
DOI:10.1111/os.13809