Enantioselective Synthesis of Amines: General, Efficient Iron‐Catalyzed Asymmetric Transfer Hydrogenation of Imines

In the iron age: A readily accessible, active iron catalyst serves in the straightforward, catalytic transfer hydrogenation of imines (see scheme). A series of imines are converted into chiral amines in high yields and very good enantioselectivities. This method should find broad application in the...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 49; no. 44; pp. 8121 - 8125
Main Authors: Zhou, Shaolin, Fleischer, Steffen, Junge, Kathrin, Das, Shoubhik, Addis, Daniele, Beller, Matthias
Format: Journal Article
Language:English
Published: Weinheim Wiley‐VCH Verlag 25.10.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Wiley
Subjects:
Amines - chemistry
asymmetric catalysis
Catalysis
Chemistry
Chemistry, Multidisciplinary
enantioselectivity
Hydrogen - chemistry
imines
Imines - chemistry
iron catalysis
Physical Sciences
Science & Technology
Stereoisomerism
transfer hydrogenation
enantioselectivity
PNNP LIGAND
AROMATIC KETONES
COMPLEXES
HYDROSILYLATION
imines
transfer hydrogenation
asymmetric catalysis
ACYCLIC IMINES
HIGHLY EFFICIENT
EPOXIDATION
iron catalysis
DERIVATIVES
REDUCTIVE AMINATION
STRECKER REACTION
ISSN:1433-7851, 1521-3773, 1521-3773
Online Access:Get full text
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Summary:In the iron age: A readily accessible, active iron catalyst serves in the straightforward, catalytic transfer hydrogenation of imines (see scheme). A series of imines are converted into chiral amines in high yields and very good enantioselectivities. This method should find broad application in the search for bioactive chiral amines.
Bibliography:http://dx.doi.org/10.1002/anie.201002456
BMBF
istex:D3A21C3EB756CE6689B455AD84FC1DB22653C4C6
State of Mecklenburg-Western Pomerania
DFG
ark:/67375/WNG-1GS85CND-6
ArticleID:ANIE201002456
This work was funded by the State of Mecklenburg-Western Pomerania, the BMBF, and the DFG (Leibniz prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, and A. Kammer, A. Koch, S. Rossmeisl, and K. Mevius for their excellent technical and analytical support.
This work was funded by the State of Mecklenburg‐Western Pomerania, the BMBF, and the DFG (Leibniz prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, and A. Kammer, A. Koch, S. Rossmeisl, and K. Mevius for their excellent technical and analytical support.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201002456