Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering

Small‐molecule stabilization of protein–protein interactions (PPIs) is a promising concept in drug discovery, however the question how to identify or design chemical starting points in a “bottom‐up” approach is largely unanswered. We report a novel concept for identifying initial chemical matter for...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 59; no. 48; pp. 21520 - 21524
Main Authors:	Wolter, Madita, Valenti, Dario, Cossar, Peter J., Levy, Laura M., Hristeva, Stanimira, Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 23.11.2020 Wiley Subscription Services, Inc John Wiley and Sons Inc
Edition:	International ed. in English
Subjects:	14-3-3 proteins 14-3-3 Proteins - chemistry Adapter proteins Adapters Adhesives Chemistry Chemistry, Multidisciplinary Communication Communications cooperative effects Crystallography Drug development fragment-based drug discovery Fragments Glues imine chemistry Imines - chemistry Lysine Molecular Structure Optimization Peptides Physical Sciences Protein Binding Protein interaction Protein Stability Proteins protein–protein interactions Science & Technology Small Molecule Libraries - chemistry Stabilization Structure-Activity Relationship Tethering Transcription Factor RelA - chemistry 14-3-3 proteins fragment-based drug discovery DRUG DISCOVERY TARGETS imine chemistry cooperative effects protein-protein interactions
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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