Synthetic Biology: Engineering Mammalian Cells To Control Cell‐to‐Cell Communication at Will

Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell‐to‐cell communication for therapeutic and other purposes. Here, we review state‐of‐the‐art engineering...

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Published in:ChemBioChem Vol. 20; no. 8; pp. 994 - 1002
Main Authors: Kojima, Ryosuke, Fussenegger, Martin
Format: Journal Article
Language:English
Published: Germany Wiley 15.04.2019
Wiley Subscription Services, Inc
Subjects:
Animals
antitumor agents
Artificial tissues
bioengineering
Biological activity
Biology
Cancer
Cell Communication
Cell interactions
cell-based therapy
cell-to-cell communication
Communication
Exosomes
Humans
Infectious diseases
Mammalian cells
Mammals
Pattern formation
Synthetic Biology
synthetic biology
cell-to-cell communication
cell-based therapy
antitumor agents
bioengineering
ISSN:1439-4227, 1439-7633, 1439-7633
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Abstract Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell‐to‐cell communication for therapeutic and other purposes. Here, we review state‐of‐the‐art engineering principles to control cell‐to‐cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell‐based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them. It′s good to talk: This minireview highlights state‐of‐the‐art engineering principles for rational control of cell‐to‐cell communication, focusing on communication between mammalian cells by diffusible factors (e.g., small molecules or exosomes) or by direct cell contact, and interkingdom communication between mammalian cells and bacteria. Future biomedical applications might include therapies for various intractable diseases.
AbstractList Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell‐to‐cell communication for therapeutic and other purposes. Here, we review state‐of‐the‐art engineering principles to control cell‐to‐cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell‐based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them.
Cell-to-cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell-to-cell communication for therapeutic and other purposes. Here, we review state-of-the-art engineering principles to control cell-to-cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell-based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them.Cell-to-cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell-to-cell communication for therapeutic and other purposes. Here, we review state-of-the-art engineering principles to control cell-to-cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell-based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them.
Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell‐to‐cell communication for therapeutic and other purposes. Here, we review state‐of‐the‐art engineering principles to control cell‐to‐cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell‐based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them. It′s good to talk: This minireview highlights state‐of‐the‐art engineering principles for rational control of cell‐to‐cell communication, focusing on communication between mammalian cells by diffusible factors (e.g., small molecules or exosomes) or by direct cell contact, and interkingdom communication between mammalian cells and bacteria. Future biomedical applications might include therapies for various intractable diseases.
Author Martin Fussenegger
Ryosuke Kojima
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  organization: University of Basel
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Cites_doi 10.1002/advs.201700971
10.1126/science.aab4077
10.1038/s41467-018-04223-7
10.3402/jev.v5.31053
10.1016/j.biomaterials.2013.09.071
10.1038/nbt.2459
10.1016/j.cell.2007.10.040
10.1038/nbt.4111
10.1016/j.cell.2017.09.049
10.1038/s41467-018-03733-8
10.1016/j.yexcr.2007.11.023
10.1038/cr.2014.137
10.1038/nnano.2017.57
10.1016/j.devcel.2018.01.023
10.1016/j.immuni.2017.06.008
10.1016/j.cell.2016.01.011
10.1126/scisignal.2002764
10.1016/j.celrep.2017.08.044
10.1016/j.addr.2016.05.006
10.7554/eLife.02786
10.1126/science.aar6711
10.1021/acs.nanolett.7b02270
10.1039/b902070p
10.1038/nrmicro1578
10.1038/nchembio.2253
10.1073/pnas.0701382104
10.1016/j.cell.2018.03.038
10.1038/s41419-018-0918-x
10.1016/j.cell.2016.01.012
10.1038/nchembio.2498
10.1126/scitranslmed.3006597
10.3402/jev.v4.26316
10.1038/nrc.2016.105
10.1016/j.cell.2016.09.011
10.1038/nrn.2017.149
10.1126/science.aat0271
10.1016/j.cell.2018.05.039
10.1038/nbt.1807
10.1016/j.cbpa.2015.05.021
10.1038/mto.2016.11
10.1038/cr.2008.64
10.1002/jbm.a.35205
10.1038/s41577-018-0042-2
10.1038/nature11220
10.1038/nbt.2351
10.1016/j.biocel.2015.12.006
10.1038/nmeth.4505
10.1126/scisignal.2005123
10.1038/s41589-018-0046-z
10.1038/nature24624
10.1038/nchembio.2565
10.1186/s13036-015-0011-2
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cell-to-cell communication
cell-based therapy
antitumor agents
bioengineering
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2012; 30
2015; 350
2018; 174
2016; 5
2018; 9
2018; 18
2015; 28
2018; 173
2018; 5
2014; 3
2016; 3
2018; 359
2017; 17
2013; 31
2017; 13
2007; 131
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References_xml – volume: 3
  start-page: 02876
  year: 2014
  publication-title: eLife
– volume: 9
  start-page: 897
  year: 2018
  publication-title: Cell Death Dis.
– volume: 5
  start-page: 757
  year: 2009
  end-page: 763
  publication-title: Mol. Biosyst.
– volume: 14
  start-page: 42
  year: 2018
  end-page: 49
  publication-title: Nat. Chem. Biol.
– volume: 5
  start-page: 1700971
  year: 2018
  publication-title: Adv. Sci.
– volume: 20
  start-page: 2639
  year: 2017
  end-page: 2653
  publication-title: Cell Rep.
– volume: 9
  start-page: 1822
  year: 2018
  publication-title: Nat. Commun.
– volume: 350
  start-page: 4077
  year: 2015
  publication-title: Science
– volume: 36
  start-page: 352
  year: 2018
  end-page: 358
  publication-title: Nat. Biotechnol.
– volume: 14
  start-page: 317
  year: 2018
  end-page: 324
  publication-title: Nat. Chem. Biol.
– volume: 35
  start-page: 779
  year: 2014
  end-page: 791
  publication-title: Biomaterials
– volume: 167
  start-page: 419
  year: 2016
  end-page: 432
  publication-title: Cell
– volume: 131
  start-page: 966
  year: 2007
  end-page: 979
  publication-title: Cell
– volume: 13
  start-page: 202
  year: 2017
  end-page: 209
  publication-title: Nat. Chem. Biol.
– volume: 487
  start-page: 64
  year: 2012
  end-page: 69
  publication-title: Nature
– volume: 5
  start-page: 215ra
  year: 2013
  publication-title: Sci. Transl. Med.
– volume: 314
  start-page: 699
  year: 2008
  end-page: 706
  publication-title: Exp. Cell Res.
– volume: 24
  start-page: 1288
  year: 2014
  end-page: 1298
  publication-title: Cell Res.
– volume: 3
  start-page: 16011
  year: 2016
  publication-title: Mol. Ther. Oncolytics
– volume: 17
  start-page: 5043
  year: 2017
  end-page: 5050
  publication-title: Nano Lett.
– volume: 30
  start-page: 991
  year: 2012
  end-page: 996
  publication-title: Nat. Biotechnol.
– volume: 9
  start-page: 1305
  year: 2018
  publication-title: Nat. Commun.
– volume: 551
  start-page: 313
  year: 2017
  end-page: 320
  publication-title: Nature
– volume: 104
  start-page: 10435
  year: 2007
  end-page: 10440
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 4
  start-page: 26316
  year: 2015
  publication-title: J. Extracell. Vesicles
– volume: 16
  start-page: 775
  year: 2016
  end-page: 788
  publication-title: Nat. Rev. Cancer
– volume: 173
  start-page: 1426
  year: 2018
  end-page: 1438
  publication-title: Cell
– volume: 7
  start-page: 4
  year: 2014
  publication-title: Sci. Signaling
– volume: 9
  start-page: 13
  year: 2015
  publication-title: J. Biol. Eng.
– volume: 18
  start-page: 605
  year: 2018
  end-page: 616
  publication-title: Nat. Rev. Immunol.
– volume: 5
  start-page: 31053
  year: 2016
  publication-title: J. Extracell. Vesicles
– volume: 28
  start-page: 29
  year: 2015
  end-page: 38
  publication-title: Curr. Opin. Chem. Biol.
– volume: 46
  start-page: 927
  year: 2017
  end-page: 942
  publication-title: Immunity
– volume: 103
  start-page: 846
  year: 2015
  end-page: 859
  publication-title: J. Biomed. Mater. Res. Part A
– volume: 29
  start-page: 341
  year: 2011
  end-page: 345
  publication-title: Nat. Biotechnol.
– volume: 105
  start-page: 66
  year: 2016
  end-page: 76
  publication-title: Adv. Drug Delivery Rev.
– volume: 45
  start-page: 10
  year: 2018
  end-page: 32
  publication-title: Dev. Cell
– volume: 164
  start-page: 770
  year: 2016
  end-page: 779
  publication-title: Cell
– volume: 19
  start-page: 17
  year: 2017
  end-page: 33
  publication-title: Nat. Rev. Neurosci.
– volume: 12
  start-page: 813
  year: 2017
  end-page: 820
  publication-title: Nat. Nanotechnol.
– volume: 174
  start-page: 259
  year: 2018
  end-page: 270
  publication-title: Cell
– volume: 14
  start-page: 723
  year: 2018
  end-page: 729
  publication-title: Nat. Chem. Biol.
– volume: 18
  start-page: 705
  year: 2008
  end-page: 707
  publication-title: Cell Res.
– volume: 361
  start-page: 156
  year: 2018
  end-page: 162
  publication-title: Science
– volume: 359
  start-page: 1361
  year: 2018
  end-page: 1365
  publication-title: Science
– volume: 31
  start-page: 71
  year: 2013
  end-page: 75
  publication-title: Nat. Biotechnol.
– volume: 15
  start-page: 57
  year: 2018
  end-page: 60
  publication-title: Nat. Methods
– volume: 71
  start-page: 44
  year: 2016
  end-page: 54
  publication-title: Int. J. Biochem. Cell Biol.
– volume: 171
  start-page: 1138
  year: 2017
  end-page: 1150
  publication-title: Cell
– volume: 5
  start-page: 57
  year: 2007
  end-page: 69
  publication-title: Nat. Rev. Microbiol.
– volume: 5
  start-page: 31
  year: 2012
  publication-title: Sci. Signaling
– volume: 164
  start-page: 780
  year: 2016
  end-page: 791
  publication-title: Cell
– ident: e_1_2_8_45_1
– ident: e_1_2_8_37_1
  doi: 10.1002/advs.201700971
– ident: e_1_2_8_23_1
  doi: 10.1126/science.aab4077
– ident: e_1_2_8_42_1
  doi: 10.1038/s41467-018-04223-7
– ident: e_1_2_8_50_1
  doi: 10.3402/jev.v5.31053
– ident: e_1_2_8_54_1
  doi: 10.1016/j.biomaterials.2013.09.071
– ident: e_1_2_8_21_1
  doi: 10.1038/nbt.2459
– ident: e_1_2_8_35_1
  doi: 10.1016/j.cell.2007.10.040
– ident: e_1_2_8_56_1
  doi: 10.1038/nbt.4111
– ident: e_1_2_8_52_1
  doi: 10.1016/j.cell.2017.09.049
– ident: e_1_2_8_15_1
  doi: 10.1038/s41467-018-03733-8
– ident: e_1_2_8_12_1
  doi: 10.1016/j.yexcr.2007.11.023
– ident: e_1_2_8_40_2
  doi: 10.1038/cr.2014.137
– ident: e_1_2_8_55_1
  doi: 10.1038/nnano.2017.57
– ident: e_1_2_8_3_1
  doi: 10.1016/j.devcel.2018.01.023
– ident: e_1_2_8_4_1
– ident: e_1_2_8_5_2
  doi: 10.1016/j.immuni.2017.06.008
– ident: e_1_2_8_31_1
  doi: 10.1016/j.cell.2016.01.011
– ident: e_1_2_8_32_1
  doi: 10.1126/scisignal.2002764
– ident: e_1_2_8_46_2
  doi: 10.1016/j.celrep.2017.08.044
– ident: e_1_2_8_19_2
  doi: 10.1016/j.addr.2016.05.006
– ident: e_1_2_8_39_2
  doi: 10.7554/eLife.02786
– ident: e_1_2_8_20_1
  doi: 10.1126/science.aar6711
– ident: e_1_2_8_43_1
  doi: 10.1021/acs.nanolett.7b02270
– ident: e_1_2_8_11_1
  doi: 10.1039/b902070p
– ident: e_1_2_8_2_1
  doi: 10.1038/nrmicro1578
– ident: e_1_2_8_48_2
  doi: 10.1038/nchembio.2253
– ident: e_1_2_8_10_1
  doi: 10.1073/pnas.0701382104
– ident: e_1_2_8_17_1
– ident: e_1_2_8_24_1
  doi: 10.1016/j.cell.2018.03.038
– ident: e_1_2_8_26_1
  doi: 10.1038/s41419-018-0918-x
– ident: e_1_2_8_29_1
  doi: 10.1016/j.cell.2016.01.012
– ident: e_1_2_8_28_1
  doi: 10.1038/nchembio.2498
– ident: e_1_2_8_22_1
  doi: 10.1126/scitranslmed.3006597
– ident: e_1_2_8_51_1
  doi: 10.3402/jev.v4.26316
– ident: e_1_2_8_8_1
  doi: 10.1038/nrc.2016.105
– ident: e_1_2_8_30_1
  doi: 10.1016/j.cell.2016.09.011
– ident: e_1_2_8_7_1
  doi: 10.1038/nrn.2017.149
– ident: e_1_2_8_33_1
  doi: 10.1126/science.aat0271
– ident: e_1_2_8_44_1
  doi: 10.1016/j.cell.2018.05.039
– ident: e_1_2_8_16_1
  doi: 10.1038/nbt.1807
– ident: e_1_2_8_18_2
  doi: 10.1016/j.cbpa.2015.05.021
– ident: e_1_2_8_27_1
  doi: 10.1038/mto.2016.11
– ident: e_1_2_8_36_1
  doi: 10.1038/cr.2008.64
– ident: e_1_2_8_53_1
  doi: 10.1002/jbm.a.35205
– ident: e_1_2_8_25_1
  doi: 10.1038/s41577-018-0042-2
– ident: e_1_2_8_41_1
  doi: 10.1038/nature11220
– ident: e_1_2_8_13_1
  doi: 10.1038/nbt.2351
– ident: e_1_2_8_6_2
  doi: 10.1016/j.biocel.2015.12.006
– ident: e_1_2_8_14_1
  doi: 10.1038/nmeth.4505
– ident: e_1_2_8_34_1
  doi: 10.1126/scisignal.2005123
– ident: e_1_2_8_38_1
– ident: e_1_2_8_47_2
  doi: 10.1038/s41589-018-0046-z
– ident: e_1_2_8_1_1
  doi: 10.1038/nature24624
– ident: e_1_2_8_49_2
  doi: 10.1038/nchembio.2565
– ident: e_1_2_8_9_1
  doi: 10.1186/s13036-015-0011-2
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Snippet Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making...
Cell-to-cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making...
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SubjectTerms Animals
antitumor agents
Artificial tissues
bioengineering
Biological activity
Biology
Cancer
Cell Communication
Cell interactions
cell-based therapy
cell-to-cell communication
Communication
Exosomes
Humans
Infectious diseases
Mammalian cells
Mammals
Pattern formation
Synthetic Biology
Title Synthetic Biology: Engineering Mammalian Cells To Control Cell‐to‐Cell Communication at Will
URI https://cir.nii.ac.jp/crid/1873961342998778880
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbic.201800682
https://www.ncbi.nlm.nih.gov/pubmed/30589185
https://www.proquest.com/docview/2209583739
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Volume 20
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