Synthetic Biology: Engineering Mammalian Cells To Control Cell‐to‐Cell Communication at Will

Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell‐to‐cell communication for therapeutic and other purposes. Here, we review state‐of‐the‐art engineering...

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Published in:ChemBioChem Vol. 20; no. 8; pp. 994 - 1002
Main Authors: Kojima, Ryosuke, Fussenegger, Martin
Format: Journal Article
Language:English
Published: Germany Wiley 15.04.2019
Wiley Subscription Services, Inc
Subjects:
Animals
antitumor agents
Artificial tissues
bioengineering
Biological activity
Biology
Cancer
Cell Communication
Cell interactions
cell-based therapy
cell-to-cell communication
Communication
Exosomes
Humans
Infectious diseases
Mammalian cells
Mammals
Pattern formation
Synthetic Biology
synthetic biology
cell-to-cell communication
cell-based therapy
antitumor agents
bioengineering
ISSN:1439-4227, 1439-7633, 1439-7633
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Abstract Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell‐to‐cell communication for therapeutic and other purposes. Here, we review state‐of‐the‐art engineering principles to control cell‐to‐cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell‐based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them. It′s good to talk: This minireview highlights state‐of‐the‐art engineering principles for rational control of cell‐to‐cell communication, focusing on communication between mammalian cells by diffusible factors (e.g., small molecules or exosomes) or by direct cell contact, and interkingdom communication between mammalian cells and bacteria. Future biomedical applications might include therapies for various intractable diseases.
AbstractList Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell‐to‐cell communication for therapeutic and other purposes. Here, we review state‐of‐the‐art engineering principles to control cell‐to‐cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell‐based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them.
Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell‐to‐cell communication for therapeutic and other purposes. Here, we review state‐of‐the‐art engineering principles to control cell‐to‐cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell‐based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them. It′s good to talk: This minireview highlights state‐of‐the‐art engineering principles for rational control of cell‐to‐cell communication, focusing on communication between mammalian cells by diffusible factors (e.g., small molecules or exosomes) or by direct cell contact, and interkingdom communication between mammalian cells and bacteria. Future biomedical applications might include therapies for various intractable diseases.
Cell-to-cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell-to-cell communication for therapeutic and other purposes. Here, we review state-of-the-art engineering principles to control cell-to-cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell-based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them.Cell-to-cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making it possible to rationally engineer cell-to-cell communication for therapeutic and other purposes. Here, we review state-of-the-art engineering principles to control cell-to-cell communication, focusing on communication between mammalian cells with diffusible factors (e.g., small molecules or exosomes) or direct cell contact, and on interkingdom communication between mammalian cells and bacteria. Potential applications include construction of artificial tissues able to perform complex computations, sophisticated cell-based cancer therapies, use of mammalian cells as a new class of cargo delivery modality, development of design principles to control pattern formation of cell populations, and treatment of infectious diseases. We also discuss the challenges facing practical applications, and possible enabling technologies to overcome them.
Author Martin Fussenegger
Ryosuke Kojima
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  organization: University of Basel
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cell-to-cell communication
cell-based therapy
antitumor agents
bioengineering
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Snippet Cell‐to‐cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making...
Cell-to-cell communication plays a key role in the regulation of many natural biological processes. Recent advances in mammalian synthetic biology are making...
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SubjectTerms Animals
antitumor agents
Artificial tissues
bioengineering
Biological activity
Biology
Cancer
Cell Communication
Cell interactions
cell-based therapy
cell-to-cell communication
Communication
Exosomes
Humans
Infectious diseases
Mammalian cells
Mammals
Pattern formation
Synthetic Biology
Title Synthetic Biology: Engineering Mammalian Cells To Control Cell‐to‐Cell Communication at Will
URI https://cir.nii.ac.jp/crid/1873961342998778880
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbic.201800682
https://www.ncbi.nlm.nih.gov/pubmed/30589185
https://www.proquest.com/docview/2209583739
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Volume 20
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