Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation

Background Platelet activation can lead to enhanced oxidative stress, inflammatory response, and endothelial dysfunction. To quantify the effects of platelet inhibition on endothelial function, we assessed platelet activity of healthy persons before and after clopidogrel administration and evaluated...

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Bibliographic Details
Published in:	Journal of the American Heart Association Vol. 5; no. 11
Main Authors:	Salimi, Shabnam, Lewis, Joshua P., Yerges‐Armstrong, Laura M., Mitchell, Braxton D., Saeed, Faisal, O'Connell, Jeffry R., Perry, James A., Ryan, Kathleen A., Shuldiner, Alan R., Parsa, Afshin
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01.11.2016 Wiley
Subjects:	Adult Aged Clopidogrel Cytochrome P-450 CYP2C19 - genetics endothelial function Endothelium, Vascular - drug effects Female Genotype Healthy Volunteers Humans Hyperemia - genetics Hyperemia - physiopathology Laser-Doppler Flowmetry Male Microcirculation - drug effects Microcirculation - genetics Middle Aged Original Research Platelet Activation - drug effects Platelet Activation - genetics platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation - genetics Platelet Aggregation Inhibitors - pharmacology Skin - blood supply Ticlopidine - analogs & derivatives Ticlopidine - pharmacology women Young Adult clopidogrel endothelial function platelet aggregation women
ISSN:	2047-9980, 2047-9980
Online Access:	Get full text
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