Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study

The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We ai...

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Published in:	Scientific reports Vol. 6; no. 1; p. 21090
Main Authors:	Agrawal, Rupesh, Gupta, Preeti, Tan, Kara-Anne, Cheung, Chui Ming Gemmy, Wong, Tien-Yin, Cheng, Ching-Yu
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.02.2016 Nature Publishing Group
Subjects:	639/624/1107/510 692/699/3161/3177 Aged Aged, 80 and over Aging Choroid - blood supply Choroid Diseases - diagnosis Choroid Diseases - pathology Coefficient of variation Diabetic retinopathy Eye Eye diseases Female Glaucoma Humanities and Social Sciences Humans Macular degeneration Male Middle Aged multidisciplinary Pathogenesis Population Population studies Population-based studies Science
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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Abstract	The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We aimed to establish normative database for CVI and identify factors associated with CVI in healthy eyes. In this population-based study on 345 healthy eyes, choroidal enhanced depth imaging optical coherence tomography scans were segmented by modified image binarization technique. Total subfoveal choroidal area (TCA) was segmented into luminal (LA) and stromal (SA) area. CVI was calculated as the proportion of LA to TCA. Linear regression was used to identify ocular and systemic factors associated with CVI and subfoveal choroidal thickness (SFCT). Subfoveal CVI ranged from 60.07 to 71.27% with a mean value of 65.61 ± 2.33%. CVI was less variable than SFCT (coefficient of variation for CVI was 3.55 vs 40.30 for SFCT). Higher CVI was associated with thicker SFCT, but not associated with most physiological variables. CVI was elucidated as a significant determinant of SFCT. While SFCT was affected by many factors, CVI remained unaffected suggesting CVI to be a more robust marker of choroidal diseases.
AbstractList	The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We aimed to establish normative database for CVI and identify factors associated with CVI in healthy eyes. In this population-based study on 345 healthy eyes, choroidal enhanced depth imaging optical coherence tomography scans were segmented by modified image binarization technique. Total subfoveal choroidal area (TCA) was segmented into luminal (LA) and stromal (SA) area. CVI was calculated as the proportion of LA to TCA. Linear regression was used to identify ocular and systemic factors associated with CVI and subfoveal choroidal thickness (SFCT). Subfoveal CVI ranged from 60.07 to 71.27% with a mean value of 65.61 ± 2.33%. CVI was less variable than SFCT (coefficient of variation for CVI was 3.55 vs 40.30 for SFCT). Higher CVI was associated with thicker SFCT, but not associated with most physiological variables. CVI was elucidated as a significant determinant of SFCT. While SFCT was affected by many factors, CVI remained unaffected suggesting CVI to be a more robust marker of choroidal diseases. The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We aimed to establish normative database for CVI and identify factors associated with CVI in healthy eyes. In this population-based study on 345 healthy eyes, choroidal enhanced depth imaging optical coherence tomography scans were segmented by modified image binarization technique. Total subfoveal choroidal area (TCA) was segmented into luminal (LA) and stromal (SA) area. CVI was calculated as the proportion of LA to TCA. Linear regression was used to identify ocular and systemic factors associated with CVI and subfoveal choroidal thickness (SFCT). Subfoveal CVI ranged from 60.07 to 71.27% with a mean value of 65.61 ± 2.33%. CVI was less variable than SFCT (coefficient of variation for CVI was 3.55 vs 40.30 for SFCT). Higher CVI was associated with thicker SFCT, but not associated with most physiological variables. CVI was elucidated as a significant determinant of SFCT. While SFCT was affected by many factors, CVI remained unaffected suggesting CVI to be a more robust marker of choroidal diseases.The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We aimed to establish normative database for CVI and identify factors associated with CVI in healthy eyes. In this population-based study on 345 healthy eyes, choroidal enhanced depth imaging optical coherence tomography scans were segmented by modified image binarization technique. Total subfoveal choroidal area (TCA) was segmented into luminal (LA) and stromal (SA) area. CVI was calculated as the proportion of LA to TCA. Linear regression was used to identify ocular and systemic factors associated with CVI and subfoveal choroidal thickness (SFCT). Subfoveal CVI ranged from 60.07 to 71.27% with a mean value of 65.61 ± 2.33%. CVI was less variable than SFCT (coefficient of variation for CVI was 3.55 vs 40.30 for SFCT). Higher CVI was associated with thicker SFCT, but not associated with most physiological variables. CVI was elucidated as a significant determinant of SFCT. While SFCT was affected by many factors, CVI remained unaffected suggesting CVI to be a more robust marker of choroidal diseases.
ArticleNumber	21090
Author	Wong, Tien-Yin Cheung, Chui Ming Gemmy Agrawal, Rupesh Gupta, Preeti Tan, Kara-Anne Cheng, Ching-Yu
Author_xml	– sequence: 1 givenname: Rupesh surname: Agrawal fullname: Agrawal, Rupesh organization: Singapore Eye Research Institute and Singapore National Eye Center, National Healthcare Group Eye Institute, Tan Tock Seng Hospital – sequence: 2 givenname: Preeti surname: Gupta fullname: Gupta, Preeti organization: Singapore Eye Research Institute and Singapore National Eye Center, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System – sequence: 3 givenname: Kara-Anne surname: Tan fullname: Tan, Kara-Anne organization: Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System – sequence: 4 givenname: Chui Ming Gemmy surname: Cheung fullname: Cheung, Chui Ming Gemmy organization: Singapore Eye Research Institute and Singapore National Eye Center, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Duke-NUS Graduate Medical School – sequence: 5 givenname: Tien-Yin surname: Wong fullname: Wong, Tien-Yin organization: Singapore Eye Research Institute and Singapore National Eye Center, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Duke-NUS Graduate Medical School – sequence: 6 givenname: Ching-Yu surname: Cheng fullname: Cheng, Ching-Yu organization: Singapore Eye Research Institute and Singapore National Eye Center, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Duke-NUS Graduate Medical School
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26868048$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1136/bjophthalmol-2014-305353 10.1364/BOE.4.000397 10.1016/j.ophtha.2014.04.038 10.1177/001316447303300309 10.1080/09286580600878844 10.1136/bjophthalmol-2012-302393 10.3341/kjo.2013.27.6.433 10.1097/IAE.0000000000000489 10.1097/ALN.0b013e31823d7784 10.1016/j.ajo.2015.03.005 10.1016/S0140-6736(86)90837-8 10.1097/ICU.0b013e3282fb7c33 10.1007/s00417-011-1620-1 10.1016/j.ajo.2009.04.029 10.1167/iovs.14-14933 10.1016/j.preteyeres.2009.12.002 10.1001/jamaophthalmol.2013.4321 10.1097/IAE.0b013e3182753b5a 10.1136/bjo.59.11.631 10.1016/j.ajo.2014.10.034 10.1167/iovs.12-11503 10.1016/j.ajo.2008.05.032 10.1016/j.ophtha.2010.09.012 10.1159/000324050 10.1167/iovs.14-14915 10.1167/iovs.08-3325 10.1001/archopht.1991.01080090096030 10.1167/iovs.14-14447 10.1016/0014-4835(73)90185-1 10.1016/j.ajo.2003.09.042 10.1016/j.ophtha.2013.01.066 10.2147/OPTH.S59395 10.1097/IAE.0b013e3182a6b3f6 10.1016/j.ajo.2014.08.001 10.1136/bjo.86.2.238 10.5120/18107-9291 10.1371/journal.pone.0048631 10.1111/aos.12631 10.1186/s12886-015-0014-2
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References	Gupta (CR36) 2015; 159 Farias (CR27) 2014; 121 Bland, Altman (CR41) 1986; 1 Grossniklaus, Green (CR6) 2004; 137 Gerendas (CR25) 2014; 158 Ahn, Woo, Park (CR20) 2014; 55 CR17 CR39 CR38 Sizmaz (CR21) 2013; 97 Lee, Lim, Shin (CR23) 2013; 27 CR32 Chung, Kang, Lee, Kim (CR3) 2011; 118 Takahashi (CR22) 2014; 34 Bland, Altman (CR42) 2012; 116 Fryczkowski, Sato, Hodes (CR11) 1988; 20 Unsal (CR24) 2014; 8 Alm, Bill (CR1) 1973; 15 Nickla, Wallman (CR2) 2010; 29 Foong (CR33) 2007; 14 Sonoda (CR30) 2014; 55 Branchini (CR13) 2013; 120 Lindner (CR14) 2015; 56 Sakamoto, Murata, Inomata (CR12) 1991; 109 Fujiwara, Imamura, Margolis, Slakter, Spaide (CR4) 2009; 148 Fleiss, Cohen (CR40) 1973; 33 CR29 Adhi, Brewer, Waheed, Duker (CR26) 2013; 131 Hayreh (CR37) 1975; 59 Gomi, Tano (CR5) 2008; 19 Wong, Wong, Zhao, Lai (CR19) 2013; 33 Tian, Marziliano, Baskaran, Tun, Aung (CR35) 2013; 4 Ikuno, Tano (CR8) 2009; 50 Sonoda (CR31) 2015; 159 Foster, Buhrmann, Quigley, Johnson (CR34) 2002; 86 Kim, Lee, Joe, Kim, Yoon (CR18) 2013; 54 Young, Fallah, Forooghian (CR15) 2015; 35 Tseng, Chen (CR16) 2015; 99 Lutty, Cao, McLeod (CR10) 1997; 151 Gupta, Mohamed (CR7) 2011; 225 Koizumi, Yamagishi, Yamazaki, Kawasaki, Kinoshita (CR9) 2011; 249 Spaide, Koizumi, Pozzoni (CR28) 2008; 146 SJ Ahn (BFsrep21090_CR20) 2014; 55 P Gupta (BFsrep21090_CR36) 2015; 159 B Gupta (BFsrep21090_CR7) 2011; 225 S Sizmaz (BFsrep21090_CR21) 2013; 97 SS Hayreh (BFsrep21090_CR37) 1975; 59 LB Farias (BFsrep21090_CR27) 2014; 121 A Alm (BFsrep21090_CR1) 1973; 15 S Sonoda (BFsrep21090_CR30) 2014; 55 M Adhi (BFsrep21090_CR26) 2013; 131 BS Gerendas (BFsrep21090_CR25) 2014; 158 BFsrep21090_CR29 AW Foong (BFsrep21090_CR33) 2007; 14 JM Bland (BFsrep21090_CR42) 2012; 116 J Tian (BFsrep21090_CR35) 2013; 4 M Lindner (BFsrep21090_CR14) 2015; 56 M Young (BFsrep21090_CR15) 2015; 35 HK Lee (BFsrep21090_CR23) 2013; 27 Y Ikuno (BFsrep21090_CR8) 2009; 50 H Takahashi (BFsrep21090_CR22) 2014; 34 LA Branchini (BFsrep21090_CR13) 2013; 120 SE Chung (BFsrep21090_CR3) 2011; 118 E Unsal (BFsrep21090_CR24) 2014; 8 H Koizumi (BFsrep21090_CR9) 2011; 249 JL Fleiss (BFsrep21090_CR40) 1973; 33 S Sonoda (BFsrep21090_CR31) 2015; 159 T Fujiwara (BFsrep21090_CR4) 2009; 148 JT Kim (BFsrep21090_CR18) 2013; 54 BFsrep21090_CR38 BFsrep21090_CR17 RF Spaide (BFsrep21090_CR28) 2008; 146 PJ Foster (BFsrep21090_CR34) 2002; 86 BFsrep21090_CR39 AW Fryczkowski (BFsrep21090_CR11) 1988; 20 CC Tseng (BFsrep21090_CR16) 2015; 99 GA Lutty (BFsrep21090_CR10) 1997; 151 IY Wong (BFsrep21090_CR19) 2013; 33 BFsrep21090_CR32 T Sakamoto (BFsrep21090_CR12) 1991; 109 JM Bland (BFsrep21090_CR41) 1986; 1 DL Nickla (BFsrep21090_CR2) 2010; 29 F Gomi (BFsrep21090_CR5) 2008; 19 HE Grossniklaus (BFsrep21090_CR6) 2004; 137 25395485 - Invest Ophthalmol Vis Sci. 2014 Dec;55(12):7775-85 18639219 - Am J Ophthalmol. 2008 Oct;146(4):496-500 17365815 - Ophthalmic Epidemiol. 2007 Jan-Feb;14(1):25-35 23189132 - PLoS One. 2012;7(11):e48631 3190107 - Ann Ophthalmol. 1988 Aug;20(8):299-305 18408495 - Curr Opin Ophthalmol. 2008 May;19(3):208-12 23504041 - Biomed Opt Express. 2013 Mar 1;4(3):397-411 15013874 - Am J Ophthalmol. 2004 Mar;137(3):496-503 25884956 - BMC Ophthalmol. 2015;15:19 24707168 - Clin Ophthalmol. 2014 Mar 27;8:637-42 23418198 - Br J Ophthalmol. 2013 May;97(5):601-4 25811950 - Retina. 2015 Apr;35(4):798-802 22129533 - Anesthesiology. 2012 Jan;116(1):182-5 9284819 - Am J Pathol. 1997 Sep;151(3):707-14 23979311 - Retina. 2014 Apr;34(4):775-80 25680621 - Br J Ophthalmol. 2015 Aug;99(8):1070-7 20044062 - Prog Retin Eye Res. 2010 Mar;29(2):144-68 23907153 - JAMA Ophthalmol. 2013 Oct;131(10):1267-74 23664466 - Ophthalmology. 2013 Sep;120(9):1901-8 24894395 - Invest Ophthalmol Vis Sci. 2014 Jun;55(6):3893-9 19279309 - Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3876-80 21325872 - Ophthalmologica. 2011;225(4):207-10 812547 - Br J Ophthalmol. 1975 Nov;59(11):631-48 21274555 - Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1123-8 25587059 - Invest Ophthalmol Vis Sci. 2015 Feb;56(2):875-82 23611988 - Invest Ophthalmol Vis Sci. 2013 May;54(5):3378-84 25447120 - Am J Ophthalmol. 2015 Feb;159(2):293-301.e3 11815354 - Br J Ophthalmol. 2002 Feb;86(2):238-42 23089893 - Retina. 2013 Feb;33(2):423-8 1929956 - Arch Ophthalmol. 1991 Sep;109(9):1270-4 24311929 - Korean J Ophthalmol. 2013 Dec;27(6):433-9 24908206 - Ophthalmology. 2014 Oct;121(10):2071-3 4630581 - Exp Eye Res. 1973 Jan 1;15(1):15-29 19541286 - Am J Ophthalmol. 2009 Sep;148(3):445-50 25790737 - Am J Ophthalmol. 2015 Jun;159(6):1123-1131.e1 21211846 - Ophthalmology. 2011 May;118(5):840-5 25127697 - Am J Ophthalmol. 2014 Nov;158(5):1039-48 2868172 - Lancet. 1986 Feb 8;1(8476):307-10 25529388 - Acta Ophthalmol. 2015 Nov;93(7):e585-92
References_xml	– volume: 99 start-page: 1070 year: 2015 end-page: 1077 ident: CR16 article-title: Long-term efficacy of half-dose photodynamic therapy on chronic central serous chorioretinopathy publication-title: Br J Ophthalmol doi: 10.1136/bjophthalmol-2014-305353 – volume: 4 start-page: 397 year: 2013 end-page: 411 ident: CR35 article-title: Automatic segmentation of the choroid in enhanced depth imaging optical coherence tomography images publication-title: Biomed Opt Express doi: 10.1364/BOE.4.000397 – volume: 151 start-page: 707 year: 1997 end-page: 714 ident: CR10 article-title: Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid publication-title: Am J Pathol – volume: 20 start-page: 299 year: 1988 end-page: 305 ident: CR11 article-title: Changes in the diabetic choroidal vasculature: scanning electron microscopy findings publication-title: Ann Ophthalmol – volume: 121 start-page: 2071 year: 2014 end-page: 2073 ident: CR27 article-title: Choroidal thickness in patients with diabetes and microalbuminuria publication-title: Ophthalmology doi: 10.1016/j.ophtha.2014.04.038 – volume: 33 start-page: 613 year: 1973 end-page: 619 ident: CR40 article-title: The Equivalence of Weighted Kappa and the Intraclass Correlation Coefficient as Measures of Reliability publication-title: Educational and Psychological Measurement doi: 10.1177/001316447303300309 – volume: 14 start-page: 25 year: 2007 end-page: 35 ident: CR33 article-title: Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES) publication-title: Ophthalmic Epidemiol doi: 10.1080/09286580600878844 – volume: 97 start-page: 601 year: 2013 end-page: 604 ident: CR21 article-title: The effect of smoking on choroidal thickness measured by optical coherence tomography publication-title: Br J Ophthalmol doi: 10.1136/bjophthalmol-2012-302393 – volume: 27 start-page: 433 year: 2013 end-page: 439 ident: CR23 article-title: Comparison of choroidal thickness in patients with diabetes by spectral-domain optical coherence tomography publication-title: Korean J Ophthalmol doi: 10.3341/kjo.2013.27.6.433 – volume: 35 start-page: 798 year: 2015 end-page: 802 ident: CR15 article-title: Choroidal degeneration in birdshot chorioretinopathy publication-title: Retina doi: 10.1097/IAE.0000000000000489 – ident: CR39 – volume: 116 start-page: 182 year: 2012 end-page: 185 ident: CR42 article-title: Agreed statistics: measurement method comparison publication-title: Anesthesiology doi: 10.1097/ALN.0b013e31823d7784 – volume: 159 start-page: 1123 year: 2015 end-page: 1131 ident: CR31 article-title: Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2015.03.005 – ident: CR29 – volume: 1 start-page: 307 year: 1986 end-page: 310 ident: CR41 article-title: Statistical methods for assessing agreement between two methods of clinical measurement publication-title: Lancet doi: 10.1016/S0140-6736(86)90837-8 – volume: 19 start-page: 208 year: 2008 end-page: 212 ident: CR5 article-title: Polypoidal choroidal vasculopathy and treatments publication-title: Curr Opin Ophthalmol doi: 10.1097/ICU.0b013e3282fb7c33 – volume: 249 start-page: 1123 year: 2011 end-page: 1128 ident: CR9 article-title: Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy publication-title: Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-011-1620-1 – volume: 148 start-page: 445 year: 2009 end-page: 450 ident: CR4 article-title: Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2009.04.029 – volume: 56 start-page: 875 year: 2015 end-page: 882 ident: CR14 article-title: Choroidal thickness in geographic atrophy secondary to age-related macular degeneration publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.14-14933 – volume: 29 start-page: 144 year: 2010 end-page: 168 ident: CR2 article-title: The multifunctional choroid publication-title: Prog Retin Eye Res doi: 10.1016/j.preteyeres.2009.12.002 – volume: 131 start-page: 1267 year: 2013 end-page: 1274 ident: CR26 article-title: Analysis of morphological features and vascular layers of choroid in diabetic retinopathy using spectral-domain optical coherence tomography publication-title: JAMA Ophthalmol doi: 10.1001/jamaophthalmol.2013.4321 – volume: 33 start-page: 423 year: 2013 end-page: 428 ident: CR19 article-title: Choroidal thickness in relation to hypercholesterolemia on enhanced depth imaging optical coherence tomography publication-title: Retina doi: 10.1097/IAE.0b013e3182753b5a – volume: 59 start-page: 631 year: 1975 end-page: 648 ident: CR37 article-title: Segmental nature of the choroidal vasculature publication-title: Br J Ophthalmol doi: 10.1136/bjo.59.11.631 – volume: 159 start-page: 293 year: 2015 end-page: 301 ident: CR36 article-title: Distribution and determinants of choroidal thickness and volume using automated segmentation software in a population-based study publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2014.10.034 – volume: 54 start-page: 3378 year: 2013 end-page: 3384 ident: CR18 article-title: Changes in choroidal thickness in relation to the severity of retinopathy and macular edema in type 2 diabetic patients publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.12-11503 – volume: 146 start-page: 496 year: 2008 end-page: 500 ident: CR28 article-title: Enhanced depth imaging spectral-domain optical coherence tomography publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2008.05.032 – volume: 118 start-page: 840 year: 2011 end-page: 845 ident: CR3 article-title: Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration publication-title: Ophthalmology doi: 10.1016/j.ophtha.2010.09.012 – volume: 225 start-page: 207 year: 2011 end-page: 210 ident: CR7 article-title: Photodynamic therapy for variant central serous chorioretinopathy: efficacy and side effects publication-title: Ophthalmologica doi: 10.1159/000324050 – volume: 55 start-page: 7775 year: 2014 end-page: 7785 ident: CR20 article-title: Retinal and choroidal changes with severe hypertension and their association with visual outcome publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.14-14915 – ident: CR38 – volume: 50 start-page: 3876 year: 2009 end-page: 3880 ident: CR8 article-title: Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.08-3325 – ident: CR17 – volume: 109 start-page: 1270 year: 1991 end-page: 1274 ident: CR12 article-title: Class II major histocompatibility complex on melanocytes of Vogt-Koyanagi-Harada disease publication-title: Arch Ophthalmol doi: 10.1001/archopht.1991.01080090096030 – volume: 55 start-page: 3893 year: 2014 end-page: 3899 ident: CR30 article-title: Choroidal structure in normal eyes and after photodynamic therapy determined by binarization of optical coherence tomographic images publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.14-14447 – volume: 15 start-page: 15 year: 1973 end-page: 29 ident: CR1 article-title: Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues publication-title: Exp Eye Res doi: 10.1016/0014-4835(73)90185-1 – volume: 137 start-page: 496 year: 2004 end-page: 503 ident: CR6 article-title: Choroidal neovascularization publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2003.09.042 – ident: CR32 – volume: 120 start-page: 1901 year: 2013 end-page: 1908 ident: CR13 article-title: Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral-domain optical coherence tomography publication-title: Ophthalmology doi: 10.1016/j.ophtha.2013.01.066 – volume: 8 start-page: 637 year: 2014 end-page: 642 ident: CR24 article-title: Choroidal thickness in patients with diabetic retinopathy publication-title: Clin Ophthalmol doi: 10.2147/OPTH.S59395 – volume: 34 start-page: 775 year: 2014 end-page: 780 ident: CR22 article-title: Choroidal thickness in convalescent vogt-koyanagi-harada disease publication-title: Retina doi: 10.1097/IAE.0b013e3182a6b3f6 – volume: 158 start-page: 1039 year: 2014 end-page: 1048 ident: CR25 article-title: Three-dimensional automated choroidal volume assessment on standard spectral-domain optical coherence tomography and correlation with the level of diabetic macular edema publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2014.08.001 – volume: 86 start-page: 238 year: 2002 end-page: 242 ident: CR34 article-title: The definition and classification of glaucoma in prevalence surveys publication-title: Br J Ophthalmol doi: 10.1136/bjo.86.2.238 – volume: 146 start-page: 496 year: 2008 ident: BFsrep21090_CR28 publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2008.05.032 – ident: BFsrep21090_CR38 doi: 10.5120/18107-9291 – ident: BFsrep21090_CR29 doi: 10.1371/journal.pone.0048631 – volume: 4 start-page: 397 year: 2013 ident: BFsrep21090_CR35 publication-title: Biomed Opt Express doi: 10.1364/BOE.4.000397 – volume: 97 start-page: 601 year: 2013 ident: BFsrep21090_CR21 publication-title: Br J Ophthalmol doi: 10.1136/bjophthalmol-2012-302393 – volume: 8 start-page: 637 year: 2014 ident: BFsrep21090_CR24 publication-title: Clin Ophthalmol doi: 10.2147/OPTH.S59395 – volume: 20 start-page: 299 year: 1988 ident: BFsrep21090_CR11 publication-title: Ann Ophthalmol – volume: 225 start-page: 207 year: 2011 ident: BFsrep21090_CR7 publication-title: Ophthalmologica doi: 10.1159/000324050 – volume: 33 start-page: 423 year: 2013 ident: BFsrep21090_CR19 publication-title: Retina doi: 10.1097/IAE.0b013e3182753b5a – volume: 86 start-page: 238 year: 2002 ident: BFsrep21090_CR34 publication-title: Br J Ophthalmol doi: 10.1136/bjo.86.2.238 – volume: 109 start-page: 1270 year: 1991 ident: BFsrep21090_CR12 publication-title: Arch Ophthalmol doi: 10.1001/archopht.1991.01080090096030 – volume: 99 start-page: 1070 year: 2015 ident: BFsrep21090_CR16 publication-title: Br J Ophthalmol doi: 10.1136/bjophthalmol-2014-305353 – volume: 151 start-page: 707 year: 1997 ident: BFsrep21090_CR10 publication-title: Am J Pathol – volume: 137 start-page: 496 year: 2004 ident: BFsrep21090_CR6 publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2003.09.042 – volume: 55 start-page: 7775 year: 2014 ident: BFsrep21090_CR20 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.14-14915 – volume: 249 start-page: 1123 year: 2011 ident: BFsrep21090_CR9 publication-title: Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-011-1620-1 – volume: 14 start-page: 25 year: 2007 ident: BFsrep21090_CR33 publication-title: Ophthalmic Epidemiol doi: 10.1080/09286580600878844 – volume: 158 start-page: 1039 year: 2014 ident: BFsrep21090_CR25 publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2014.08.001 – volume: 50 start-page: 3876 year: 2009 ident: BFsrep21090_CR8 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.08-3325 – volume: 54 start-page: 3378 year: 2013 ident: BFsrep21090_CR18 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.12-11503 – volume: 159 start-page: 293 year: 2015 ident: BFsrep21090_CR36 publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2014.10.034 – volume: 35 start-page: 798 year: 2015 ident: BFsrep21090_CR15 publication-title: Retina doi: 10.1097/IAE.0000000000000489 – volume: 121 start-page: 2071 year: 2014 ident: BFsrep21090_CR27 publication-title: Ophthalmology doi: 10.1016/j.ophtha.2014.04.038 – volume: 29 start-page: 144 year: 2010 ident: BFsrep21090_CR2 publication-title: Prog Retin Eye Res doi: 10.1016/j.preteyeres.2009.12.002 – volume: 120 start-page: 1901 year: 2013 ident: BFsrep21090_CR13 publication-title: Ophthalmology doi: 10.1016/j.ophtha.2013.01.066 – volume: 131 start-page: 1267 year: 2013 ident: BFsrep21090_CR26 publication-title: JAMA Ophthalmol doi: 10.1001/jamaophthalmol.2013.4321 – volume: 27 start-page: 433 year: 2013 ident: BFsrep21090_CR23 publication-title: Korean J Ophthalmol doi: 10.3341/kjo.2013.27.6.433 – volume: 55 start-page: 3893 year: 2014 ident: BFsrep21090_CR30 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.14-14447 – volume: 15 start-page: 15 year: 1973 ident: BFsrep21090_CR1 publication-title: Exp Eye Res doi: 10.1016/0014-4835(73)90185-1 – volume: 148 start-page: 445 year: 2009 ident: BFsrep21090_CR4 publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2009.04.029 – ident: BFsrep21090_CR39 – volume: 34 start-page: 775 year: 2014 ident: BFsrep21090_CR22 publication-title: Retina doi: 10.1097/IAE.0b013e3182a6b3f6 – volume: 118 start-page: 840 year: 2011 ident: BFsrep21090_CR3 publication-title: Ophthalmology doi: 10.1016/j.ophtha.2010.09.012 – ident: BFsrep21090_CR17 doi: 10.1111/aos.12631 – volume: 116 start-page: 182 year: 2012 ident: BFsrep21090_CR42 publication-title: Anesthesiology doi: 10.1097/ALN.0b013e31823d7784 – volume: 56 start-page: 875 year: 2015 ident: BFsrep21090_CR14 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.14-14933 – volume: 59 start-page: 631 year: 1975 ident: BFsrep21090_CR37 publication-title: Br J Ophthalmol doi: 10.1136/bjo.59.11.631 – ident: BFsrep21090_CR32 doi: 10.1186/s12886-015-0014-2 – volume: 19 start-page: 208 year: 2008 ident: BFsrep21090_CR5 publication-title: Curr Opin Ophthalmol doi: 10.1097/ICU.0b013e3282fb7c33 – volume: 159 start-page: 1123 year: 2015 ident: BFsrep21090_CR31 publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2015.03.005 – volume: 1 start-page: 307 year: 1986 ident: BFsrep21090_CR41 publication-title: Lancet doi: 10.1016/S0140-6736(86)90837-8 – volume: 33 start-page: 613 year: 1973 ident: BFsrep21090_CR40 publication-title: Educational and Psychological Measurement doi: 10.1177/001316447303300309 – reference: 25529388 - Acta Ophthalmol. 2015 Nov;93(7):e585-92 – reference: 812547 - Br J Ophthalmol. 1975 Nov;59(11):631-48 – reference: 25811950 - Retina. 2015 Apr;35(4):798-802 – reference: 24707168 - Clin Ophthalmol. 2014 Mar 27;8:637-42 – reference: 3190107 - Ann Ophthalmol. 1988 Aug;20(8):299-305 – reference: 23189132 - PLoS One. 2012;7(11):e48631 – reference: 25790737 - Am J Ophthalmol. 2015 Jun;159(6):1123-1131.e1 – reference: 21325872 - Ophthalmologica. 2011;225(4):207-10 – reference: 24894395 - Invest Ophthalmol Vis Sci. 2014 Jun;55(6):3893-9 – reference: 25884956 - BMC Ophthalmol. 2015;15:19 – reference: 20044062 - Prog Retin Eye Res. 2010 Mar;29(2):144-68 – reference: 4630581 - Exp Eye Res. 1973 Jan 1;15(1):15-29 – reference: 25587059 - Invest Ophthalmol Vis Sci. 2015 Feb;56(2):875-82 – reference: 25447120 - Am J Ophthalmol. 2015 Feb;159(2):293-301.e3 – reference: 22129533 - Anesthesiology. 2012 Jan;116(1):182-5 – reference: 24311929 - Korean J Ophthalmol. 2013 Dec;27(6):433-9 – reference: 21274555 - Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1123-8 – reference: 18639219 - Am J Ophthalmol. 2008 Oct;146(4):496-500 – reference: 1929956 - Arch Ophthalmol. 1991 Sep;109(9):1270-4 – reference: 2868172 - Lancet. 1986 Feb 8;1(8476):307-10 – reference: 11815354 - Br J Ophthalmol. 2002 Feb;86(2):238-42 – reference: 9284819 - Am J Pathol. 1997 Sep;151(3):707-14 – reference: 25395485 - Invest Ophthalmol Vis Sci. 2014 Dec;55(12):7775-85 – reference: 19541286 - Am J Ophthalmol. 2009 Sep;148(3):445-50 – reference: 23418198 - Br J Ophthalmol. 2013 May;97(5):601-4 – reference: 23504041 - Biomed Opt Express. 2013 Mar 1;4(3):397-411 – reference: 23664466 - Ophthalmology. 2013 Sep;120(9):1901-8 – reference: 25680621 - Br J Ophthalmol. 2015 Aug;99(8):1070-7 – reference: 18408495 - Curr Opin Ophthalmol. 2008 May;19(3):208-12 – reference: 19279309 - Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3876-80 – reference: 15013874 - Am J Ophthalmol. 2004 Mar;137(3):496-503 – reference: 21211846 - Ophthalmology. 2011 May;118(5):840-5 – reference: 23611988 - Invest Ophthalmol Vis Sci. 2013 May;54(5):3378-84 – reference: 23907153 - JAMA Ophthalmol. 2013 Oct;131(10):1267-74 – reference: 24908206 - Ophthalmology. 2014 Oct;121(10):2071-3 – reference: 25127697 - Am J Ophthalmol. 2014 Nov;158(5):1039-48 – reference: 23089893 - Retina. 2013 Feb;33(2):423-8 – reference: 23979311 - Retina. 2014 Apr;34(4):775-80 – reference: 17365815 - Ophthalmic Epidemiol. 2007 Jan-Feb;14(1):25-35
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Snippet	The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate...
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StartPage	21090
SubjectTerms	639/624/1107/510 692/699/3161/3177 Aged Aged, 80 and over Aging Choroid - blood supply Choroid Diseases - diagnosis Choroid Diseases - pathology Coefficient of variation Diabetic retinopathy Eye Eye diseases Female Glaucoma Humanities and Social Sciences Humans Macular degeneration Male Middle Aged multidisciplinary Pathogenesis Population Population studies Population-based studies Science
Title	Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study
URI	https://link.springer.com/article/10.1038/srep21090 https://www.ncbi.nlm.nih.gov/pubmed/26868048 https://www.proquest.com/docview/1899028675 https://www.proquest.com/docview/1765116469 https://pubmed.ncbi.nlm.nih.gov/PMC4751574
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