Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study

The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We ai...

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Vydáno v:Scientific reports Ročník 6; číslo 1; s. 21090
Hlavní autoři: Agrawal, Rupesh, Gupta, Preeti, Tan, Kara-Anne, Cheung, Chui Ming Gemmy, Wong, Tien-Yin, Cheng, Ching-Yu
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 12.02.2016
Nature Publishing Group
Témata:
639/624/1107/510
692/699/3161/3177
Aged
Aged, 80 and over
Aging
Choroid - blood supply
Choroid Diseases - diagnosis
Choroid Diseases - pathology
Coefficient of variation
Diabetic retinopathy
Eye
Eye diseases
Female
Glaucoma
Humanities and Social Sciences
Humans
Macular degeneration
Male
Middle Aged
multidisciplinary
Pathogenesis
Population
Population studies
Population-based studies
Science
ISSN:2045-2322, 2045-2322
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Shrnutí:The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We aimed to establish normative database for CVI and identify factors associated with CVI in healthy eyes. In this population-based study on 345 healthy eyes, choroidal enhanced depth imaging optical coherence tomography scans were segmented by modified image binarization technique. Total subfoveal choroidal area (TCA) was segmented into luminal (LA) and stromal (SA) area. CVI was calculated as the proportion of LA to TCA. Linear regression was used to identify ocular and systemic factors associated with CVI and subfoveal choroidal thickness (SFCT). Subfoveal CVI ranged from 60.07 to 71.27% with a mean value of 65.61 ± 2.33%. CVI was less variable than SFCT (coefficient of variation for CVI was 3.55 vs 40.30 for SFCT). Higher CVI was associated with thicker SFCT, but not associated with most physiological variables. CVI was elucidated as a significant determinant of SFCT. While SFCT was affected by many factors, CVI remained unaffected suggesting CVI to be a more robust marker of choroidal diseases.
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These authors contributed equally to this work.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep21090