Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels

The structure and function of arteries change throughout a lifetime. Age is the dominant risk factor for hypertension, coronary heart disease, congestive heart failure, and stroke. The cellular/molecular proinflammatory alterations that underlie arterial aging are novel putative candidates to be tar...

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Vydáno v:The Medical clinics of North America Ročník 93; číslo 3; s. 583
Hlavní autoři: Lakatta, Edward G, Wang, Mingyi, Najjar, Samer S
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.05.2009
Témata:
Age Factors
Aged
Aged, 80 and over
Aging
Angiotensin II - metabolism
Animals
Coronary Artery Disease - diagnosis
Coronary Artery Disease - pathology
Coronary Vessels - pathology
Endothelium, Vascular - physiopathology
Female
Humans
Hypertension - complications
Hypertension - pathology
Male
Risk Factors
ISSN:1557-9859, 1557-9859
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Shrnutí:The structure and function of arteries change throughout a lifetime. Age is the dominant risk factor for hypertension, coronary heart disease, congestive heart failure, and stroke. The cellular/molecular proinflammatory alterations that underlie arterial aging are novel putative candidates to be targeted by interventions aimed at attenuating arterial aging as a major risk factor for cardiovascular diseases. This review provides a landscape of central arterial aging and age-disease interactions, integrating perspectives that range from humans to molecules, with the goal that future therapies for cardiovascular diseases, such as hypertension, also will target the prevention or amelioration of unsuccessful arterial aging.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1557-9859
1557-9859
DOI:10.1016/j.mcna.2009.02.008