Immunohistochemical localization of renin-containing cells in two elasmobranch species

Renin immunoreactivity was localized at the light and electron microscopic level in two elasmobranch fish species, the Atlantic stingray, Dasyatis sabina , and river ray, Potamotrygon humerosa . At the light microscopic level, the peroxidase–anti-peroxidase method showed a positive immunoreactivity...

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Vydáno v:	Fish physiology and biochemistry Ročník 42; číslo 3; s. 995 - 1004
Hlavní autoři:	Lacy, E. R., Reale, E., Luciano, L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Dordrecht Springer Netherlands 01.06.2016 Springer Nature B.V
Témata:	Animal Anatomy Animal Biochemistry Animal Physiology Animals arterioles Arterioles - anatomy & histology Arterioles - metabolism Arterioles - ultrastructure Biomedical and Life Sciences birds blood flow Blood pressure Dasyatidae Dasyatis sabina Elasmobranchii Elasmobranchii - anatomy & histology Elasmobranchii - metabolism electron microscopy Enzymes fish Freshwater & Marine Ecology Gastric Mucosa - metabolism granules Histology Immunohistochemistry Kidney - anatomy & histology Kidney - metabolism kidneys Life Sciences Localization mammals Microscopy Microscopy, Electron Morphology myocytes Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - ultrastructure Phylogenetics Potamotrygon Rectum - metabolism Rectum - ultrastructure renin Renin - metabolism renin-angiotensin system Reptiles rivers Seawater Smooth muscle Stomach - anatomy & histology Teleostei Vertebrates Zoology United States > US A, Atlantic Stenohaline Juxtaglomerular apparatus RAS Stingray Kidney Euryhaline
ISSN:	0920-1742, 1573-5168, 1573-5168
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Shrnutí:	Renin immunoreactivity was localized at the light and electron microscopic level in two elasmobranch fish species, the Atlantic stingray, Dasyatis sabina , and river ray, Potamotrygon humerosa . At the light microscopic level, the peroxidase–anti-peroxidase method showed a positive immunoreactivity in modified smooth muscle cells in kidney afferent arterioles as well as in arterioles of several organs: rectal gland, inter-renal gland, conus arteriosus, and gill. Electron microscopic renin-positive immunogold localization was confined to the contents of membrane bound granules in the modified smooth muscle cells of these arterioles. The presence of renin-containing granules in the modified smooth muscle, “granular cells,” of the renal glomerular afferent arteriole of these two stingray species adds support to earlier studies which showed the structural components of a complete juxtaglomerular apparatus and some of the biochemical and molecular components of a renin–angiotensin system (RAS) as found in teleost fish, reptiles, birds, and mammals. A notable result, however, was the renin-positive immunoreaction in the arteriolar wall of all other organs studied here. The presence of this “diffuse renin system” in the connective tissue of various organs suggests that in these two stingray species in addition to local organ-specific functions, the RAS may act as a systemic mechanism to regulate blood pressure and blood flow in the body.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0920-1742 1573-5168 1573-5168
DOI:	10.1007/s10695-015-0191-1