Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction

This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for acute myocardial infarction (AMI). We measured the circulating levels of 15 individual lncRNAs, known to be relevant to cardiovascular disease, using the whole blood samples collected from 103...

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Veröffentlicht in:Scientific reports Jg. 6; H. 1; S. 22384
Hauptverfasser: Zhang, Ying, Sun, Lihua, Xuan, Lina, Pan, Zhenwei, Li, Kang, Liu, Shuangshuang, Huang, Yuechao, Zhao, Xuyun, Huang, Lihua, Wang, Zhiguo, Hou, Yan, Li, Junnan, Tian, Ye, Yu, Jiahui, Han, Hui, Liu, Yanhong, Gao, Fei, Zhang, Yong, Wang, Shu, Du, Zhimin, Lu, Yanjie, Yang, Baofeng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.03.2016
Nature Publishing Group
Schlagworte:
38/90
692/4019/592/75/2/1674
692/53/2421
Animals
Antisense RNA
Biomarkers
Biomarkers - blood
Blood
Cardiac arrhythmia
Cardiovascular diseases
Complementarity-determining region 1
Disease Models, Animal
Heart attacks
Humanities and Social Sciences
Humans
Mice
Mice, Inbred C57BL
Middle Aged
multidisciplinary
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Prognosis
RNA, Long Noncoding - blood
Rodents
Science
Zinc finger proteins
ISSN:2045-2322, 2045-2322
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Zusammenfassung:This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for acute myocardial infarction (AMI). We measured the circulating levels of 15 individual lncRNAs, known to be relevant to cardiovascular disease, using the whole blood samples collected from 103 AMI patients, 149 non-AMI subjects and 95 healthy volunteers. We found that only two of them, Zinc finger antisense 1 ( ZFAS1 ) and Cdr1 antisense ( CDR1AS ), showed significant differential expression between AMI patients and control subjects. Circulating level of ZFAS1 was significantly lower in AMI (0.74 ± 0.07) than in non-AMI subjects (1.0 ± 0.05, P  < 0.0001), whereas CDR1AS showed the opposite changes with its blood level markedly higher in AMI (2.18 ± 0.24) than in non-AMI subjects (1.0 ± 0.05, P  < 0.0001). When comparison was made between AMI and non-AMI, the area under ROC curve was 0.664 for ZFAS1 alone or 0.671 for CDR1AS alone and 0.691 for ZFAS1 and CDR1AS combination. Univariate and multivariate analyses identified these two lncRNAs as independent predictors for AMI. Similar changes of circulating ZFAS1 and CDR1AS were consistently observed in an AMI mouse model. Reciprocal changes of circulating ZFAS1 and CDR1AS independently predict AMI and may be considered novel biomarkers of AMI.
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These authors contributed equally to this work.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep22384