Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses

Reston viruses are the only Ebolaviruses that are not pathogenic in humans. We analyzed 196 Ebolavirus genomes and identified specificity determining positions (SDPs) in all nine Ebolavirus proteins that distinguish Reston viruses from the four human pathogenic Ebolaviruses. A subset of these SDPs w...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 23743
Main Authors:	Pappalardo, Morena, Juliá, Miguel, Howard, Mark J., Rossman, Jeremy S., Michaelis, Martin, Wass, Mark N.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.03.2016 Nature Publishing Group
Subjects:	631/114 631/208/726/649 alpha Karyopherins - metabolism Amino Acid Sequence Animals Conserved Sequence Domestic animals Ebolavirus - genetics Ebolavirus - metabolism Ebolavirus - pathogenicity Genetic Variation Genomes Hemorrhagic Fever, Ebola - transmission Hemorrhagic Fever, Ebola - veterinary Host Specificity Humanities and Social Sciences Humans Hydrophobicity Interferon Models, Molecular multidisciplinary Pathogenicity Pathogens Phylogeny Protein Conformation Proteins Science Structural analysis Swine Swine Diseases - transmission Swine Diseases - virology Viral Matrix Proteins - chemistry Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Virulence Factors - genetics Virulence Factors - metabolism Viruses VP24 protein VP40 protein
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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