Quantitative Analysis of Porcine Endogenous Retroviruses in Different Organs of Transgenic Pigs Generated for Xenotransplantation
The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of bot...
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| Vydané v: | Current microbiology Ročník 67; číslo 4; s. 505 - 514 |
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| Hlavní autori: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Boston
Springer US
01.10.2013
Springer Nature B.V |
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| ISSN: | 0343-8651, 1432-0991, 1432-0991 |
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| Abstract | The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of both PERV DNA and RNA. Therefore, the present study focuses on quantitative analysis of PERVs in different organs such as the skin, heart, muscle, and liver and blood of transgenic pigs generated for xenotransplantation. Transgenic pigs were developed to express the human α-galactosidase, the human α-1,2-fucosyltransferase gene, or both genetic modifications of the genome (Lipinski et al., Medycyna Wet 66:316–322,
2010
; Lipinski et al., Ann Anim Sci 12:349–356,
2012
; Wieczorek et al., Medycyna Wet 67:462–466,
2011
). The copy numbers of PERV DNA and RNA were evaluated using real-time Q-PCR and QRT-PCR, respectively. Comparative analysis of all PERV subtypes revealed the following relationships: PERV A > PERV B > PERV C. PERV A and B were found in all samples, whereas PERV C was detected in 47 % of the tested animals. The lowest level of PERV DNA was shown in the muscles for PERV A and B and in blood samples for PERV C. The lowest level of PERV A RNA was found in the skin, whereas those of PERV B and C RNA were found in liver specimens. Quantitative analysis revealed differences in the copy number of PERV subtypes between various organs of transgenic pigs generated for xenotransplantation. Our data support the idea that careful pig selection for organ donation with low PERV copy number may limit the risk of retrovirus transmission to the human recipients. |
|---|---|
| AbstractList | The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of both PERV DNA and RNA. Therefore, the present study focuses on quantitative analysis of PERVs in different organs such as the skin, heart, muscle, and liver and blood of transgenic pigs generated for xenotransplantation. Transgenic pigs were developed to express the human [alpha]-galactosidase, the human [alpha]-1,2-fucosyltransferase gene, or both genetic modifications of the genome (Lipinski et al., Medycyna Wet 66:316-322, 2010 ; Lipinski et al., Ann Anim Sci 12:349-356, 2012 ; Wieczorek et al., Medycyna Wet 67:462-466, 2011 ). The copy numbers of PERV DNA and RNA were evaluated using real-time Q-PCR and QRT-PCR, respectively. Comparative analysis of all PERV subtypes revealed the following relationships: PERV A > PERV B > PERV C. PERV A and B were found in all samples, whereas PERV C was detected in 47 % of the tested animals. The lowest level of PERV DNA was shown in the muscles for PERV A and B and in blood samples for PERV C. The lowest level of PERV A RNA was found in the skin, whereas those of PERV B and C RNA were found in liver specimens. Quantitative analysis revealed differences in the copy number of PERV subtypes between various organs of transgenic pigs generated for xenotransplantation. Our data support the idea that careful pig selection for organ donation with low PERV copy number may limit the risk of retrovirus transmission to the human recipients.[PUBLICATION ABSTRACT] The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of both PERV DNA and RNA. Therefore, the present study focuses on quantitative analysis of PERVs in different organs such as the skin, heart, muscle, and liver and blood of transgenic pigs generated for xenotransplantation. Transgenic pigs were developed to express the human alpha -galactosidase, the human alpha -1,2-fucosyltransferase gene, or both genetic modifications of the genome (Lipinski et al., Medycyna Wet 66:316-322, 2010; Lipinski et al., Ann Anim Sci 12:349-356, 2012; Wieczorek et al., Medycyna Wet 67:462-466, 2011). The copy numbers of PERV DNA and RNA were evaluated using real-time Q-PCR and QRT-PCR, respectively. Comparative analysis of all PERV subtypes revealed the following relationships: PERV A > PERV B > PERV C. PERV A and B were found in all samples, whereas PERV C was detected in 47 % of the tested animals. The lowest level of PERV DNA was shown in the muscles for PERV A and B and in blood samples for PERV C. The lowest level of PERV A RNA was found in the skin, whereas those of PERV B and C RNA were found in liver specimens. Quantitative analysis revealed differences in the copy number of PERV subtypes between various organs of transgenic pigs generated for xenotransplantation. Our data support the idea that careful pig selection for organ donation with low PERV copy number may limit the risk of retrovirus transmission to the human recipients. The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of both PERV DNA and RNA. Therefore, the present study focuses on quantitative analysis of PERVs in different organs such as the skin, heart, muscle, and liver and blood of transgenic pigs generated for xenotransplantation. Transgenic pigs were developed to express the human α-galactosidase, the human α-1,2-fucosyltransferase gene, or both genetic modifications of the genome (Lipinski et al., Medycyna Wet 66:316-322, 2010; Lipinski et al., Ann Anim Sci 12:349-356, 2012; Wieczorek et al., Medycyna Wet 67:462-466, 2011). The copy numbers of PERV DNA and RNA were evaluated using real-time Q-PCR and QRT-PCR, respectively. Comparative analysis of all PERV subtypes revealed the following relationships: PERV A > PERV B > PERV C. PERV A and B were found in all samples, whereas PERV C was detected in 47 % of the tested animals. The lowest level of PERV DNA was shown in the muscles for PERV A and B and in blood samples for PERV C. The lowest level of PERV A RNA was found in the skin, whereas those of PERV B and C RNA were found in liver specimens. Quantitative analysis revealed differences in the copy number of PERV subtypes between various organs of transgenic pigs generated for xenotransplantation. Our data support the idea that careful pig selection for organ donation with low PERV copy number may limit the risk of retrovirus transmission to the human recipients. The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of both PERV DNA and RNA. Therefore, the present study focuses on quantitative analysis of PERVs in different organs such as the skin, heart, muscle, and liver and blood of transgenic pigs generated for xenotransplantation. Transgenic pigs were developed to express the human α-galactosidase, the human α-1,2-fucosyltransferase gene, or both genetic modifications of the genome (Lipinski et al., Medycyna Wet 66:316–322, 2010; Lipinski et al., Ann Anim Sci 12:349–356, 2012; Wieczorek et al., Medycyna Wet 67:462–466, 2011). The copy numbers of PERV DNA and RNA were evaluated using real-time Q-PCR and QRT-PCR, respectively. Comparative analysis of all PERV subtypes revealed the following relationships: PERV A > PERV B > PERV C. PERV A and B were found in all samples, whereas PERV C was detected in 47 % of the tested animals. The lowest level of PERV DNA was shown in the muscles for PERV A and B and in blood samples for PERV C. The lowest level of PERV A RNA was found in the skin, whereas those of PERV B and C RNA were found in liver specimens. Quantitative analysis revealed differences in the copy number of PERV subtypes between various organs of transgenic pigs generated for xenotransplantation. Our data support the idea that careful pig selection for organ donation with low PERV copy number may limit the risk of retrovirus transmission to the human recipients. The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of both PERV DNA and RNA. Therefore, the present study focuses on quantitative analysis of PERVs in different organs such as the skin, heart, muscle, and liver and blood of transgenic pigs generated for xenotransplantation. Transgenic pigs were developed to express the human α-galactosidase, the human α-1,2-fucosyltransferase gene, or both genetic modifications of the genome (Lipinski et al., Medycyna Wet 66:316-322, 2010; Lipinski et al., Ann Anim Sci 12:349-356, 2012; Wieczorek et al., Medycyna Wet 67:462-466, 2011). The copy numbers of PERV DNA and RNA were evaluated using real-time Q-PCR and QRT-PCR, respectively. Comparative analysis of all PERV subtypes revealed the following relationships: PERV A > PERV B > PERV C. PERV A and B were found in all samples, whereas PERV C was detected in 47 % of the tested animals. The lowest level of PERV DNA was shown in the muscles for PERV A and B and in blood samples for PERV C. The lowest level of PERV A RNA was found in the skin, whereas those of PERV B and C RNA were found in liver specimens. Quantitative analysis revealed differences in the copy number of PERV subtypes between various organs of transgenic pigs generated for xenotransplantation. Our data support the idea that careful pig selection for organ donation with low PERV copy number may limit the risk of retrovirus transmission to the human recipients.The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of both PERV DNA and RNA. Therefore, the present study focuses on quantitative analysis of PERVs in different organs such as the skin, heart, muscle, and liver and blood of transgenic pigs generated for xenotransplantation. Transgenic pigs were developed to express the human α-galactosidase, the human α-1,2-fucosyltransferase gene, or both genetic modifications of the genome (Lipinski et al., Medycyna Wet 66:316-322, 2010; Lipinski et al., Ann Anim Sci 12:349-356, 2012; Wieczorek et al., Medycyna Wet 67:462-466, 2011). The copy numbers of PERV DNA and RNA were evaluated using real-time Q-PCR and QRT-PCR, respectively. Comparative analysis of all PERV subtypes revealed the following relationships: PERV A > PERV B > PERV C. PERV A and B were found in all samples, whereas PERV C was detected in 47 % of the tested animals. The lowest level of PERV DNA was shown in the muscles for PERV A and B and in blood samples for PERV C. The lowest level of PERV A RNA was found in the skin, whereas those of PERV B and C RNA were found in liver specimens. Quantitative analysis revealed differences in the copy number of PERV subtypes between various organs of transgenic pigs generated for xenotransplantation. Our data support the idea that careful pig selection for organ donation with low PERV copy number may limit the risk of retrovirus transmission to the human recipients. The pig appears to be the most promising animal donor of organs for use in human recipients. Among several types of pathogens found in pigs, one of the greatest problems is presented by porcine endogenous retroviruses (PERVs). Screening of the source pig herd for PERVs should include analysis of both PERV DNA and RNA. Therefore, the present study focuses on quantitative analysis of PERVs in different organs such as the skin, heart, muscle, and liver and blood of transgenic pigs generated for xenotransplantation. Transgenic pigs were developed to express the human α-galactosidase, the human α-1,2-fucosyltransferase gene, or both genetic modifications of the genome (Lipinski et al., Medycyna Wet 66:316–322, 2010 ; Lipinski et al., Ann Anim Sci 12:349–356, 2012 ; Wieczorek et al., Medycyna Wet 67:462–466, 2011 ). The copy numbers of PERV DNA and RNA were evaluated using real-time Q-PCR and QRT-PCR, respectively. Comparative analysis of all PERV subtypes revealed the following relationships: PERV A > PERV B > PERV C. PERV A and B were found in all samples, whereas PERV C was detected in 47 % of the tested animals. The lowest level of PERV DNA was shown in the muscles for PERV A and B and in blood samples for PERV C. The lowest level of PERV A RNA was found in the skin, whereas those of PERV B and C RNA were found in liver specimens. Quantitative analysis revealed differences in the copy number of PERV subtypes between various organs of transgenic pigs generated for xenotransplantation. Our data support the idea that careful pig selection for organ donation with low PERV copy number may limit the risk of retrovirus transmission to the human recipients. |
| Author | Jura, Jacek Kimsa, Magdalena C. Strzalka-Mrozik, Barbara Kimsa, Malgorzata W. Szalata, Marlena Zeyland, Joanna Slomski, Ryszard Gola, Joanna Nowak, Roman Mazurek, Urszula Adamska, Jolanta Lipinski, Daniel Smorag, Zdzislaw |
| Author_xml | – sequence: 1 givenname: Urszula surname: Mazurek fullname: Mazurek, Urszula organization: Department of Molecular Biology, Medical University of Silesia – sequence: 2 givenname: Magdalena C. surname: Kimsa fullname: Kimsa, Magdalena C. email: magdakimsa@gmail.com organization: Department of Molecular Biology, Medical University of Silesia – sequence: 3 givenname: Barbara surname: Strzalka-Mrozik fullname: Strzalka-Mrozik, Barbara organization: Department of Molecular Biology, Medical University of Silesia – sequence: 4 givenname: Malgorzata W. surname: Kimsa fullname: Kimsa, Malgorzata W. organization: Department of Molecular Biology, Medical University of Silesia – sequence: 5 givenname: Jolanta surname: Adamska fullname: Adamska, Jolanta organization: Department of Molecular Biology, Medical University of Silesia – sequence: 6 givenname: Daniel surname: Lipinski fullname: Lipinski, Daniel organization: Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Institute of Human Genetics, Polish Academy of Sciences – sequence: 7 givenname: Joanna surname: Zeyland fullname: Zeyland, Joanna organization: Department of Biochemistry and Biotechnology, Poznan University of Life Sciences – sequence: 8 givenname: Marlena surname: Szalata fullname: Szalata, Marlena organization: Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Institute of Human Genetics, Polish Academy of Sciences – sequence: 9 givenname: Ryszard surname: Slomski fullname: Slomski, Ryszard organization: Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Institute of Human Genetics, Polish Academy of Sciences – sequence: 10 givenname: Jacek surname: Jura fullname: Jura, Jacek organization: Department of Animal Reproduction, The National Research Institute of Animal Production – sequence: 11 givenname: Zdzislaw surname: Smorag fullname: Smorag, Zdzislaw organization: Department of Animal Reproduction, The National Research Institute of Animal Production – sequence: 12 givenname: Roman surname: Nowak fullname: Nowak, Roman organization: Department and Clinic of Orthopaedics, Medical University of Silesia – sequence: 13 givenname: Joanna surname: Gola fullname: Gola, Joanna organization: Department of Molecular Biology, Medical University of Silesia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23728786$$D View this record in MEDLINE/PubMed |
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| Keywords | Porcine Tissue Fucosyltransferase Gene Xenograft Rejection Human Recipient Perv Infection |
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Res. 2007;35(6):e40 – reference: 20108128 - In Vitro Cell Dev Biol Anim. 2010 May;46(5):408-10 – reference: 21911159 - Transplant Proc. 2011 Sep;43(7):2762-9 – reference: 23100752 - Indian J Microbiol. 2009 Mar;49(1):68-71 – reference: 8643549 - Proc Natl Acad Sci U S A. 1996 May 28;93(11):5177-84 – reference: 21539860 - J Virol Methods. 2011 Jul;175(1):60-5 – reference: 22453682 - J Inherit Metab Dis. 2012 Jul;35(4):695-713 – reference: 10590090 - J Virol. 2000 Jan;74(1):49-56 – reference: 22307333 - Int J Artif Organs. 2012 Jan;35(1):25-33 – reference: 9811736 - J Virol. 1998 Dec;72(12):9986-91 – reference: 19568350 - Organogenesis. 2009 Jan;5(1):288-96 – reference: 2440339 - Anal Biochem. 1987 Apr;162(1):156-9 – reference: 22975674 - Virology. 2012 Nov 25;433(2):329-36 – reference: 20142847 - Mol Vis. 2010 Feb 05;16:161-6 – reference: 20706036 - J Vet Sci. 2010 Sep;11(3):269-71 – reference: 23053520 - Arch Virol. 2013 Feb;158(2):341-8 – reference: 16387182 - Transplant Proc. 2005 Dec;37(10):4610-4 – reference: 10954559 - J Virol. 2000 Sep;74(18):8575-81 – reference: 19469034 - Curr Opin Organ Transplant. 2009 Apr;14(2):175-9 – reference: 19799764 - Xenotransplantation. 2009 Jul-Aug;16(4):239-48 – reference: 15564495 - J Virol. 2004 Dec;78(24):13871-9 – reference: 16218033 - Ann Transplant. 2005;10(2):46-51 – reference: 22497513 - Xenotransplantation. 2012 Mar-Apr;19(2):112-21 – reference: 20402385 - Expert Rev Clin Immunol. 2010 Mar;6(2):219-30 – reference: 19392721 - Xenotransplantation. 2009 Mar-Apr;16(2):64-73 – reference: 21126659 - Transplant Rev (Orlando). 2011 Jan;25(1):9-20 |
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