Hepatitis B vaccination in a hyper-endemic tribal community from India: assessment after three years

Hepatitis B infection is highly endemic among the primitive tribes of Andaman and Nicobar Islands, India and it is necessary to initiate hepatitis B vaccination for control of this infection. A pilot project of mass hepatitis B vaccination using indigenously developed vaccine was initiated among Nic...

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Bibliographic Details
Published in:Vaccine Vol. 23; no. 3; pp. 399 - 403
Main Authors: Murhekar, M.V., Murhekar, K.M., Sehgal, S.C.
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 02.12.2004
Elsevier
Elsevier Limited
Subjects:
Adolescent
Adult
Age
Andaman and Nicobar Islands
Antibodies, Viral - blood
Antigens
Applied microbiology
Biological and medical sciences
Carrier State - immunology
Carrier State - prevention & control
Child
Child, Preschool
Endemic Diseases - prevention & control
Female
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis B
Hepatitis B vaccine
Hepatitis B Vaccines - administration & dosage
Hepatitis B Vaccines - immunology
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - immunology
Hepatitis B, Chronic - prevention & control
Human viral diseases
Humans
Immunization
Immunization Programs
India
India - epidemiology
Infant
Infections
Infectious diseases
Islands
Male
Medical sciences
Microbiology
Middle Aged
Pilot projects
Population
Public health
Time Factors
Tribes
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral hepatitis
Asia
India
India, Andaman and Nicobar Is
India, Andaman and Nicobar islands
Hepatitis B vaccine
Tribes
Andaman and Nicobar Islands
Hepatitis B
India
Infection
Viral hepatitis B
Viral hepatitis A
Viral disease
Vaccination
Digestive diseases
Hepatic disease
ISSN:0264-410X, 1873-2518
Online Access:Get full text
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Summary:Hepatitis B infection is highly endemic among the primitive tribes of Andaman and Nicobar Islands, India and it is necessary to initiate hepatitis B vaccination for control of this infection. A pilot project of mass hepatitis B vaccination using indigenously developed vaccine was initiated among Nicobarese tribe of Car Nicobar Island. Sero-protection rates after second and third year were 89% and 85.5%, respectively. The rate of chronic infection in the vaccinated population after three years was 1.86% compared to the pre-vaccination rate of 20.7%. Considering high sero-protection rates and low cost, the indigenous vaccine could be used for vaccination programme in this tribal community.
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ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2004.05.038