Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Predominantly Middle-Aged Adults

Insulin-like growth factor 1 (IGF-1) signaling has been implicated in Alzheimer's disease pathogenesis, and further evidence suggests inflammation can be a moderator of this association. However, most research to date has been conducted on older adults. To investigate the association of serum I...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Journal of Alzheimer's disease Ročník 88; číslo 1; s. 311
Hlavní autoři: Wittfeld, Katharina, Raman, Mekala R, Conner, Sarah C, Aslam, Asra, Teumer, Alexander, Nauck, Matthias, Hosten, Norbert, Habes, Mohamad, DeCarli, Charles, Vasan, Ramachandran S, Beiser, Alexa S, Himali, Jayandra J, Seshadri, Sudha, Grabe, Hans J, Satizabal, Claudia L
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.01.2022
Témata:
Adult
Alzheimer Disease - diagnostic imaging
Biomarkers
C-Reactive Protein - metabolism
Female
Humans
Inflammation - diagnostic imaging
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I - analysis
Magnetic Resonance Imaging
Male
Middle Aged
epidemiology
C-reactive protein
cohort study
hippocampus
Alzheimer’s disease endophenotype
insulin-like growth factor
neuroimaging
white matter hyperintensity
ISSN:1875-8908, 1875-8908
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Insulin-like growth factor 1 (IGF-1) signaling has been implicated in Alzheimer's disease pathogenesis, and further evidence suggests inflammation can be a moderator of this association. However, most research to date has been conducted on older adults. To investigate the association of serum IGF-1 and IGF binding protein 3 (IGFBP-3) concentrations with MRI markers of Alzheimer's disease in predominantly middle-aged adults, and further assess moderation by chronic inflammation. We included participants from the Framingham Heart Study (n = 1,852, mean age 46±8, 46% men) and the Study of Health in Pomerania (n = 674, mean age 50±13, 42% men) with available serum IGF-1, IFGBP-3, as well as brain MRI. IGF-1 and IFGBP-3 were related to MRI outcomes (i.e., total brain, cortical gray matter, white matter, white matter hyperintensities (WMH), and hippocampal volumes) using multivariable regression models adjusting for potential confounders. Subgroup analyses by C-reactive protein (CRP) concentrations were also performed. Cohort-specific summary statistics were meta-analyzed using random-effects models and corrected for multiple comparisons. Meta-analysis results revealed that higher IGF-1 concentrations were associated with lower WMH (estimate [β] [95% CI], -0.05 [-0.09, -0.02], p = 0.006) and larger hippocampal volumes (0.07 [0.02, 0.12], p = 0.01), independent of vascular risk factors. These associations occurred predominantly in individuals with CRP concentrations < 75th percentile. We did not observe associations between IGFBP-3 and MRI outcomes. Our findings suggest that IGF-1-related signaling may be implicated in brain health as early as midlife.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1875-8908
1875-8908
DOI:10.3233/JAD-220356