Small RNA-based antimicrobial immunity
Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their product...
Saved in:
| Published in: | Nature reviews. Immunology Vol. 19; no. 1; pp. 31 - 44 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Nature Publishing Group
01.01.2019
|
| Subjects: | |
| ISSN: | 1474-1733, 1474-1741, 1474-1741 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms. |
|---|---|
| AbstractList | Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms.Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms. Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms. Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms. |
| Author | Guo, Zhongxin Ding, Shou-Wei Li, Yang |
| Author_xml | – sequence: 1 givenname: Zhongxin surname: Guo fullname: Guo, Zhongxin organization: Vector-borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China – sequence: 2 givenname: Yang surname: Li fullname: Li, Yang organization: State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China – sequence: 3 givenname: Shou-Wei surname: Ding fullname: Ding, Shou-Wei email: shou-wei.ding@ucr.edu organization: Department of Microbiology and Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA. shou-wei.ding@ucr.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30301972$$D View this record in MEDLINE/PubMed |
| BookMark | eNpd0E1LxDAQBuAgK-6H_gAvUhDES3QmySbpcVn8gkXBj3NJ0hSyNO3atOD-ewuuHjzNwPvwMsycTJq28YScI9wgcH2bBC6VooCaAiikX0dkhkIJikrg5G_nfErmKW0BUI7JCZly4IC5YjNy9RZNXWevzytqTfJlZpo-xOC61gZTZyHGoQn9_pQcV6ZO_uwwF-Tj_u59_Ug3Lw9P69WGuiWInkojZAWmYrm0FVhWVjzXsio1t05Y8CbnTjsFUqNwDK20-ZgvrRSojTKSL8j1T--uaz8Hn_oihuR8XZvGt0MqGKLSjCkBI738R7ft0DXjdaOSTI2dgo3q4qAGG31Z7LoQTbcvfj_AvwF6glyp |
| CitedBy_id | crossref_primary_10_1016_j_plantsci_2025_112490 crossref_primary_10_1007_s12298_024_01524_8 crossref_primary_10_3390_v13060955 crossref_primary_10_1111_nph_17586 crossref_primary_10_1016_j_molp_2023_04_008 crossref_primary_10_3390_v10110581 crossref_primary_10_1016_j_chom_2020_05_001 crossref_primary_10_1007_s11427_019_1648_3 crossref_primary_10_1094_PHYTO_07_19_0267_IA crossref_primary_10_1186_s12885_025_13672_5 crossref_primary_10_1038_s41598_020_70061_7 crossref_primary_10_1146_annurev_genet_112618_043756 crossref_primary_10_1016_j_gde_2019_07_019 crossref_primary_10_1111_mpp_13091 crossref_primary_10_1073_pnas_2213701120 crossref_primary_10_1111_nph_16932 crossref_primary_10_1186_s11658_023_00469_2 crossref_primary_10_1007_s13313_021_00840_x crossref_primary_10_1111_ppa_13494 crossref_primary_10_1016_j_dci_2020_103985 crossref_primary_10_1073_pnas_2114583119 crossref_primary_10_3389_fimmu_2022_1008084 crossref_primary_10_3390_v12101121 crossref_primary_10_3390_v13112116 crossref_primary_10_1094_PHYTO_10_22_0371_R crossref_primary_10_1038_s41586_020_2231_y crossref_primary_10_3390_v12121430 crossref_primary_10_1007_s12250_019_00182_5 crossref_primary_10_1038_s41392_022_01272_9 crossref_primary_10_1093_hr_uhae164 crossref_primary_10_3390_v16101639 crossref_primary_10_3390_ijms23126758 crossref_primary_10_3389_fmolb_2020_00101 crossref_primary_10_1128_jvi_01874_21 crossref_primary_10_1016_j_postharvbio_2023_112563 crossref_primary_10_1016_j_cirep_2025_200220 crossref_primary_10_1371_journal_ppat_1010329 crossref_primary_10_1007_s00299_021_02718_0 crossref_primary_10_1038_s41467_022_34649_z crossref_primary_10_1016_j_virol_2019_08_017 crossref_primary_10_1016_j_dci_2023_104668 crossref_primary_10_1371_journal_pone_0303686 crossref_primary_10_3389_fmicb_2020_590904 crossref_primary_10_15252_embj_2021110521 crossref_primary_10_3390_ijms242216358 crossref_primary_10_1094_PHYTO_10_22_0358_IA crossref_primary_10_1099_jgv_0_001434 crossref_primary_10_3390_v11090847 crossref_primary_10_1016_j_jconrel_2020_04_003 crossref_primary_10_3389_fimmu_2024_1350267 crossref_primary_10_1073_pnas_1909183116 crossref_primary_10_3390_v13020154 crossref_primary_10_1016_j_virusres_2022_198704 crossref_primary_10_5423_PPJ_OA_12_2024_0193 crossref_primary_10_1016_j_chom_2024_08_009 crossref_primary_10_1093_bib_bbab027 crossref_primary_10_1128_jvi_00245_23 crossref_primary_10_2147_IDR_S334769 crossref_primary_10_3390_genes13050731 crossref_primary_10_7554_eLife_63194 crossref_primary_10_3390_insects15060375 crossref_primary_10_4049_jimmunol_1900804 crossref_primary_10_1038_s41586_021_03743_5 crossref_primary_10_1134_S102144372104004X crossref_primary_10_1371_journal_pbio_3001668 crossref_primary_10_1073_pnas_2322765121 crossref_primary_10_1111_pce_15511 crossref_primary_10_1002_adfm_202401547 crossref_primary_10_1146_annurev_phyto_082718_100309 crossref_primary_10_1111_mpp_12798 crossref_primary_10_1016_j_xplc_2025_101490 crossref_primary_10_1126_sciadv_adt3751 crossref_primary_10_1016_j_chom_2024_08_019 crossref_primary_10_1002_ps_7605 crossref_primary_10_1007_s44154_022_00057_y crossref_primary_10_1146_annurev_phyto_121520_023514 crossref_primary_10_1134_S1021443721030134 crossref_primary_10_1016_j_coviro_2020_12_001 crossref_primary_10_1016_j_placenta_2024_06_009 crossref_primary_10_3389_fmicb_2022_859420 crossref_primary_10_3390_v14071582 crossref_primary_10_1099_jgv_0_001779 crossref_primary_10_3390_v14020432 crossref_primary_10_1094_PHYTO_02_23_0051_IA crossref_primary_10_1016_j_pmpp_2025_102913 crossref_primary_10_1111_febs_17028 crossref_primary_10_1038_s41598_024_70974_7 crossref_primary_10_1016_j_compbiomed_2023_107886 crossref_primary_10_3390_agriculture12122108 crossref_primary_10_1016_j_coi_2022_01_005 crossref_primary_10_1073_pnas_2321170121 crossref_primary_10_1093_molbev_msae032 crossref_primary_10_1094_PHYTO_05_22_0167_RVW crossref_primary_10_1016_j_mib_2023_102337 crossref_primary_10_1038_s41422_019_0152_9 crossref_primary_10_1371_journal_ppat_1009790 crossref_primary_10_3390_v11090782 crossref_primary_10_1111_mpp_13344 crossref_primary_10_1007_s00251_021_01239_0 crossref_primary_10_3389_fimmu_2024_1386578 crossref_primary_10_1093_aob_mcac013 crossref_primary_10_1016_j_antiviral_2020_104916 crossref_primary_10_1111_nph_15994 crossref_primary_10_1016_j_tplants_2019_03_010 crossref_primary_10_1016_j_sjbs_2021_05_073 crossref_primary_10_1111_mpp_13229 crossref_primary_10_1007_s11248_021_00262_x crossref_primary_10_1371_journal_ppat_1010091 crossref_primary_10_1111_febs_16728 crossref_primary_10_1371_journal_ppat_1009549 crossref_primary_10_1371_journal_pbio_3001201 crossref_primary_10_1016_j_virs_2022_05_001 crossref_primary_10_1111_jipb_13162 crossref_primary_10_1099_jgv_0_001552 crossref_primary_10_1016_j_chom_2020_06_007 crossref_primary_10_3390_microbiolres13040056 crossref_primary_10_1038_s41422_021_00524_7 crossref_primary_10_1038_s41598_023_30827_1 crossref_primary_10_1093_nar_gkaf116 crossref_primary_10_1186_s42483_024_00298_x crossref_primary_10_1038_s41577_022_00705_4 crossref_primary_10_1128_JVI_01233_19 crossref_primary_10_1038_s41477_023_01507_9 crossref_primary_10_1038_s41467_025_56859_x crossref_primary_10_3389_fcimb_2021_628887 crossref_primary_10_1016_j_chom_2019_12_006 crossref_primary_10_1094_MPMI_12_23_0220_R crossref_primary_10_1016_j_molp_2020_02_010 crossref_primary_10_1007_s00344_022_10651_z crossref_primary_10_1128_JVI_01173_19 crossref_primary_10_1016_j_chom_2021_08_006 crossref_primary_10_1093_nar_gkab1149 crossref_primary_10_1038_s41467_025_57908_1 crossref_primary_10_1111_mpp_13441 crossref_primary_10_3390_biomedicines11020642 crossref_primary_10_3390_v15112239 crossref_primary_10_1016_j_coviro_2020_06_004 crossref_primary_10_1128_jvi_01778_21 crossref_primary_10_1038_s41467_019_12323_1 crossref_primary_10_1093_ve_vead074 crossref_primary_10_1111_jph_13040 crossref_primary_10_1007_s11427_019_1599_y crossref_primary_10_1016_j_chom_2020_02_003 crossref_primary_10_3389_fgene_2022_914029 crossref_primary_10_1128_mmbr_00035_22 crossref_primary_10_1002_slct_202002609 crossref_primary_10_3389_fimmu_2023_1287539 crossref_primary_10_1038_s41467_024_55288_6 crossref_primary_10_1016_j_jenvman_2024_120326 crossref_primary_10_3389_fmicb_2020_591619 crossref_primary_10_1111_mpp_13250 crossref_primary_10_5423_PPJ_OA_05_2025_0071 crossref_primary_10_1016_j_immuni_2023_08_006 crossref_primary_10_1371_journal_ppat_1009757 crossref_primary_10_1111_nph_20359 crossref_primary_10_1186_s42483_020_00057_8 crossref_primary_10_3390_plants10010082 crossref_primary_10_1007_s11427_020_1873_1 crossref_primary_10_3390_ijms242417153 crossref_primary_10_1126_science_abb7360 crossref_primary_10_1093_nsr_nwae245 crossref_primary_10_15252_embj_2021109902 crossref_primary_10_1111_mpp_12839 crossref_primary_10_1128_JVI_00017_20 crossref_primary_10_1016_j_bbrc_2025_151568 crossref_primary_10_1016_j_plantsci_2024_112244 crossref_primary_10_1038_s41598_020_67935_1 crossref_primary_10_1371_journal_ppat_1011386 crossref_primary_10_1016_j_chom_2022_07_004 crossref_primary_10_1146_annurev_phyto_020620_114550 crossref_primary_10_1016_j_tim_2019_08_009 crossref_primary_10_1016_j_fsi_2022_01_019 crossref_primary_10_1038_s41467_022_30771_0 crossref_primary_10_15446_rev_colomb_biote_v24n2_99397 crossref_primary_10_1016_j_heliyon_2021_e07284 crossref_primary_10_1016_j_immuni_2021_01_017 crossref_primary_10_1038_s41422_021_00568_9 crossref_primary_10_1002_ppp3_10477 crossref_primary_10_1021_acs_jafc_5c02537 crossref_primary_10_3390_plants11050635 crossref_primary_10_3390_v17070986 crossref_primary_10_1146_annurev_phyto_030320_041346 crossref_primary_10_3390_ijms21228766 crossref_primary_10_1111_mpp_13112 crossref_primary_10_1242_bio_060172 crossref_primary_10_1016_j_immuni_2021_08_027 crossref_primary_10_1016_j_tim_2019_05_007 crossref_primary_10_1093_jxb_erad327 crossref_primary_10_1111_nph_16992 crossref_primary_10_1111_brv_13151 crossref_primary_10_1016_j_tim_2020_05_018 crossref_primary_10_1016_j_pmpp_2022_101888 crossref_primary_10_1146_annurev_virology_092920_021307 crossref_primary_10_3389_fpls_2023_1163270 crossref_primary_10_15252_embj_2021108050 crossref_primary_10_1093_plphys_kiac430 crossref_primary_10_3390_v12050509 crossref_primary_10_1111_mpp_13009 crossref_primary_10_1016_j_ymthe_2024_12_009 crossref_primary_10_1016_j_tibs_2022_05_001 crossref_primary_10_3389_fmicb_2022_964156 crossref_primary_10_1016_j_isci_2025_113391 crossref_primary_10_1186_s13059_021_02410_2 crossref_primary_10_3390_v14102258 crossref_primary_10_1186_s12864_024_11062_y crossref_primary_10_3390_ijms232012071 crossref_primary_10_3390_ijms24065753 crossref_primary_10_1016_j_molp_2019_04_010 crossref_primary_10_1038_s41586_021_03800_z crossref_primary_10_1093_nar_gkaf136 crossref_primary_10_1371_journal_ppat_1011238 crossref_primary_10_3390_plants11162125 crossref_primary_10_1016_j_jmb_2024_168870 crossref_primary_10_1016_j_chom_2025_04_004 crossref_primary_10_3390_ijms23147915 crossref_primary_10_3389_fmicb_2019_01415 crossref_primary_10_3390_ijms20112816 crossref_primary_10_1080_22221751_2020_1787798 crossref_primary_10_2174_1381612826666200109181238 crossref_primary_10_1111_mpp_70008 crossref_primary_10_1016_j_cell_2022_04_030 crossref_primary_10_1016_j_virol_2025_110459 crossref_primary_10_1111_pbi_70134 crossref_primary_10_1093_hr_uhad043 crossref_primary_10_1111_pce_15204 crossref_primary_10_1038_s41586_025_08706_8 crossref_primary_10_1016_j_virusres_2021_198648 crossref_primary_10_1186_s42483_023_00192_y crossref_primary_10_1080_17429145_2021_1885758 crossref_primary_10_1101_gr_265157_120 crossref_primary_10_1016_j_ymeth_2019_08_011 crossref_primary_10_1007_s42994_025_00212_9 crossref_primary_10_1111_jipb_13213 crossref_primary_10_3389_fbioe_2022_913728 crossref_primary_10_3389_fpls_2024_1385456 crossref_primary_10_1371_journal_pgen_1007915 crossref_primary_10_3389_fimmu_2023_1053550 crossref_primary_10_1016_j_virusres_2023_199179 crossref_primary_10_1186_s42483_022_00117_1 crossref_primary_10_1038_s44318_024_00035_2 crossref_primary_10_1111_pbi_14448 crossref_primary_10_48130_epi_0025_0010 crossref_primary_10_1111_nph_17776 crossref_primary_10_15252_embj_2022111210 crossref_primary_10_3724_abbs_2024160 crossref_primary_10_3389_fcimb_2021_662447 crossref_primary_10_1002_bies_202400173 crossref_primary_10_1016_j_molp_2024_01_008 crossref_primary_10_1186_s42483_019_0041_7 crossref_primary_10_1360_TB_2025_0009 crossref_primary_10_3390_v15010026 crossref_primary_10_1080_17429145_2025_2503289 crossref_primary_10_3389_fpls_2022_876428 crossref_primary_10_1111_mpp_13394 crossref_primary_10_3390_agronomy12112790 crossref_primary_10_1371_journal_ppat_1008965 crossref_primary_10_1007_s11427_023_2477_9 crossref_primary_10_1093_plcell_koab140 crossref_primary_10_1016_j_celrep_2024_114581 crossref_primary_10_1371_journal_ppat_1010119 crossref_primary_10_3390_v13122464 crossref_primary_10_1016_j_celrep_2023_112441 crossref_primary_10_1038_s41467_023_39426_0 crossref_primary_10_1073_pnas_2108874118 crossref_primary_10_1093_nar_gkac571 crossref_primary_10_1016_j_coviro_2021_01_002 crossref_primary_10_1146_annurev_pathmechdis_031521_034739 crossref_primary_10_1007_s10327_025_01244_1 crossref_primary_10_1111_1348_0421_13083 crossref_primary_10_1073_pnas_2016673118 crossref_primary_10_1111_mpp_70020 crossref_primary_10_1016_j_heliyon_2024_e37228 crossref_primary_10_1111_nph_17758 crossref_primary_10_1007_s11427_024_2680_3 crossref_primary_10_3390_idr14050076 |
| ContentType | Journal Article |
| Copyright | Copyright Nature Publishing Group Jan 2019 |
| Copyright_xml | – notice: Copyright Nature Publishing Group Jan 2019 |
| DBID | CGR CUY CVF ECM EIF NPM 3V. 7QR 7RV 7T5 7U9 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB0 LK8 M0S M1P M7N M7P NAPCQ P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI 7X8 |
| DOI | 10.1038/s41577-018-0071-x |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Chemoreception Abstracts Nursing & Allied Health Database Immunology Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Biological Sciences ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts Proquest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest Central Student MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1474-1741 |
| EndPage | 44 |
| ExternalDocumentID | 30301972 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GroupedDBID | --- .55 0R~ 123 29M 36B 39C 4.4 53G 70F 7RV 7X7 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8R4 8R5 AARCD AAWYQ AAYZH ABAWZ ABDBF ABFSG ABJNI ABLJU ABNNU ABUWG ACGFS ACIWK ACPRK ACRPL ACSTC ACUHS ADBBV ADNMO AENEX AEUYN AEZWR AFANA AFBBN AFHIU AFKRA AFRAH AFSHS AGAYW AGGDT AGQPQ AHBCP AHMBA AHOSX AHSBF AHWEU AIBTJ AIXLP AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ALPWD ARMCB ASPBG ATHPR AVWKF AXYYD AZFZN B0M BBNVY BENPR BHPHI BKEYQ BKKNO BPHCQ BVXVI CCPQU CGR CS3 CUY CVF DB5 DU5 EAD EAP EBC EBD EBS ECM EE. EIF EJD EMB EMK EMOBN EPL ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA HCIFZ HMCUK HVGLF HZ~ IAO IHR IHW INH INR ISR ITC L-9 LK8 M1P M7P N9A NAPCQ NFIDA NNMJJ NPM O9- ODYON P2P PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO Q2X RNR RNT RNTTT SHXYY SIXXV SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP WOW X7M ~8M 3V. 7QR 7T5 7U9 7XB 8FD 8FK AGSTI AZQEC DWQXO FR3 GNUQQ H94 K9. M7N P64 PKEHL PQEST PQUKI 7X8 |
| ID | FETCH-LOGICAL-c504t-6a46f0af296bf0b2df3986fd83bc4b0ea93c8c706814c21b6b99865b6418a7a63 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 308 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000454709800010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1474-1733 1474-1741 |
| IngestDate | Sun Nov 09 12:38:45 EST 2025 Mon Oct 06 17:01:01 EDT 2025 Mon Jul 21 06:06:01 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c504t-6a46f0af296bf0b2df3986fd83bc4b0ea93c8c706814c21b6b99865b6418a7a63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23 |
| PMID | 30301972 |
| PQID | 2162764142 |
| PQPubID | 27582 |
| PageCount | 14 |
| ParticipantIDs | proquest_miscellaneous_2117822740 proquest_journals_2162764142 pubmed_primary_30301972 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-01-01 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – month: 01 year: 2019 text: 2019-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Nature reviews. Immunology |
| PublicationTitleAlternate | Nat Rev Immunol |
| PublicationYear | 2019 |
| Publisher | Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group |
| SSID | ssj0016174 |
| Score | 2.6750681 |
| SecondaryResourceType | review_article |
| Snippet | Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the... Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 31 |
| SubjectTerms | Animals Anti-Infective Agents - immunology Antimicrobial agents Antiviral activity Eukaryotic Cells - immunology Fungi Host-Pathogen Interactions - immunology Humans Mammals Mammals - immunology Molecular modelling Pathogens Plant viruses Plants - immunology RNA Interference - immunology RNA, Small Interfering - immunology RNA-mediated interference Virulence |
| Title | Small RNA-based antimicrobial immunity |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30301972 https://www.proquest.com/docview/2162764142 https://www.proquest.com/docview/2117822740 |
| Volume | 19 |
| WOSCitedRecordID | wos000454709800010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEB5848VHfVVrqSDegptsNpM9iRbFg11KfdBbyWuhoK3aKvrvTXa3etKLl7kkhDAMmW_mm8wAHGuXKyGZJdYiI9yD3lAEgCRXStuEMyuKj7QPN5hlst9Pu1XCbVKVVc7exOKhtmMTcuSnjAqGglPOzp5fSJgaFdjVaoTGPCyGLgmsKN3rfrMIouzCTDlyQjGOZ6xmLE8n3nFhKLqUJHhZ8vE7wiw8zdX6f--4AWsVxmydl0axCXNuVIPlcurkZw1WOhWfvgUnt0_q8bHVy85JcGe25fU8fBoWzZn8CcPi88j0cxvury7v2tekmpxATBLxKRGKizxSOUuFziPNbB6nUuRWxtpwHTmVxkYajISk3DCqhfZRl0i0v7tUqES8Awuj8cjtQSvJHTUOLXOJ4eijM4E-YqICI8cNd0kdGjNdDCrznwx-FFGHo-9lb7iBjVAjN34Le2hAJ8ijOuyW-h48lx02BnEI1FJk-38ffgCrHr-kZUakAQvT1zd3CEvmfTqcvDZhHnsPQfaxkNJL2aZNWLy4zLq9ZmErXmbdzhfOIr-z |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3JTsMwEB2Vsl7Yl7IGCbhZJI5jOweEKqAqolSITdyCt0iVoC20LP0pvhE7aeAENw6cE02iWTzzPBvAjjSpoBxrpDXDiNig1xUBMJQKIXVEsKZZI-1tgzWb_O4uvijBR9EL48oqizMxO6h1R7k78n0cUMwoCQg-7D4htzXKZVeLFRq5WpyZwZuFbL2D02Mr312MayfXR3U03CqAVOSTPqKC0NQXKY6pTH2JdRrGnKaah1IR6RsRh4or5lMeEIUDSaVFJDSS9ttcMEFDS3cERt0kO2dR_OirpMRBhSyLTRhBAQvDIosa8v2edZTMFXly5Lw6ev85os08W23mv_FkFqaHMbRXzZV-DkqmPQ_j-VbNwTxMnA_rBRZg7-pRPDx4l80qcu5ae1aPWo-tbPiUpdDKmmP6g0W4-ZP_XYJyu9M2K-BFqQmUYRqbSBFm0SdlFhEGlPmGKGKiCqwXvE-G5t1Lvhlfge2vx9YwXbZFtE3nxb0TuOiLEb8Cy7l8k24-QSQJHRCNGV79nfgWTNavzxtJ47R5tgZTNlaL89ufdSj3n1_MBoyp136r97yZ6aEH938t5E_1CBXv |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LTxsxEB5BKIhLSymP8NxK0JuVtddrew8VokAEgq4iaCtui59SJEiAhJb8tf662vugJ7hx4LyrkeVvxvONZ8YDsKOsk0wQg4zhBFFPekMRAEdOSmVSSgwrG2l_nfE8F5eXWW8K_ja9MKGssjkTy4PaDHW4I-8QzAhnFFPScXVZRO-wu3d7h8IEqZBpbcZpVCpyaid_fPg2-npy6LHeJaR79OPgGNUTBpBOYzpGTFLmYulIxpSLFTEuyQRzRiRKUxVbmSVaaB4zgakmWDHloxOWKr8OIblkiZc7DTPckwzagplvR3nv_CmHwao3oDHlFGGeJE1ONRGdkXebPJR8ChR8PHp8nt-Wfq774S3v0AK8r9l1tF-Zw0eYsoNFmK3mbU4WYe57XUnwCb5c3Mjr6-g830fBkZvIa1j_pl8-S-Ul9Mu2mfFkCX6-ynqXoTUYDuwqRKmzWFtuiE015T4uZdzHipjx2FJNbdqGjQaHojb8UfEfhDZ8fvrsTTbkYeTADh_CPzjwMk7jNqxUWBe31dsiRRJC1IyTtZeFb8Ocx7Y4O8lP12Hek7isuhbagNb4_sFuwjv9e9wf3W_VShnB1Wuj_A-AlCBN |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Small+RNA-based+antimicrobial+immunity&rft.jtitle=Nature+reviews.+Immunology&rft.au=Guo%2C+Zhongxin&rft.au=Yang%2C+Li&rft.au=Shou-Wei%2C+Ding&rft.date=2019-01-01&rft.pub=Nature+Publishing+Group&rft.issn=1474-1733&rft.eissn=1474-1741&rft.volume=19&rft.issue=1&rft.spage=31&rft.epage=44&rft_id=info:doi/10.1038%2Fs41577-018-0071-x&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1474-1733&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1474-1733&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1474-1733&client=summon |