Small RNA-based antimicrobial immunity

Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their product...

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Vydáno v:Nature reviews. Immunology Ročník 19; číslo 1; s. 31 - 44
Hlavní autoři: Guo, Zhongxin, Li, Yang, Ding, Shou-Wei
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.01.2019
Nature Publishing Group
Témata:
631/250/255/2514
631/337/505
Animals
Anti-Infective Agents - immunology
Antimicrobial agents
Antiviral activity
Biomedical and Life Sciences
Biomedicine
Care and treatment
Communicable diseases
Defense industry
Development and progression
Eukaryotic Cells - immunology
Fungi
Genetic aspects
Health aspects
Host-Pathogen Interactions - immunology
Humans
Immunology
Infection
Insects
Mammals
Mammals - immunology
Molecular modelling
Pathogenic microorganisms
Pathogens
Plant evolution
Plant viruses
Plants - immunology
Proteins
Review Article
RNA
RNA interference
RNA Interference - immunology
RNA, Small Interfering - immunology
RNA-mediated interference
Small interfering RNA
Virulence
Virulence (Microbiology)
ISSN:1474-1733, 1474-1741, 1474-1741
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms. The authors review the latest research revealing conserved antiviral activity of virus-derived small interfering RNAs (siRNAs) in fungi, plants, invertebrates and mammals.
AbstractList Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms.Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms.
Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms.
Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms.
Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms. The authors review the latest research revealing conserved antiviral activity of virus-derived small interfering RNAs (siRNAs) in fungi, plants, invertebrates and mammals.
Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. We also highlight the recent discovery of viral PIWI-interacting RNAs in animals and a new role for mobile host and pathogen small RNAs in plant defence against eukaryotic pathogens. In turn, viruses that infect plants, insects and mammals, as well as eukaryotic pathogens of plants, have evolved specific virulence proteins that suppress RNA interference (RNAi). Together, these advances suggest that an antimicrobial function of the RNAi pathway is conserved across eukaryotic kingdoms. The authors review the latest research revealing conserved antiviral activity of virus-derived small interfering RNAs (siRNAs) in fungi, plants, invertebrates and mammals.
Audience Academic
Author Guo, Zhongxin
Ding, Shou-Wei
Li, Yang
Author_xml – sequence: 1
  givenname: Zhongxin
  surname: Guo
  fullname: Guo, Zhongxin
  organization: Vector-borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University
– sequence: 2
  givenname: Yang
  surname: Li
  fullname: Li, Yang
  organization: State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre of Genetics and Development, School of Life Sciences, Fudan University
– sequence: 3
  givenname: Shou-Wei
  surname: Ding
  fullname: Ding, Shou-Wei
  email: shou-wei.ding@ucr.edu
  organization: Department of Microbiology and Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30301972$$D View this record in MEDLINE/PubMed
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Snippet Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the...
Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the...
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631/337/505
Animals
Anti-Infective Agents - immunology
Antimicrobial agents
Antiviral activity
Biomedical and Life Sciences
Biomedicine
Care and treatment
Communicable diseases
Defense industry
Development and progression
Eukaryotic Cells - immunology
Fungi
Genetic aspects
Health aspects
Host-Pathogen Interactions - immunology
Humans
Immunology
Infection
Insects
Mammals
Mammals - immunology
Molecular modelling
Pathogenic microorganisms
Pathogens
Plant evolution
Plant viruses
Plants - immunology
Proteins
Review Article
RNA
RNA interference
RNA Interference - immunology
RNA, Small Interfering - immunology
RNA-mediated interference
Small interfering RNA
Virulence
Virulence (Microbiology)
Title Small RNA-based antimicrobial immunity
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https://www.ncbi.nlm.nih.gov/pubmed/30301972
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Volume 19
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