Roles of long noncoding RNAs in gastric cancer and their clinical applications

Purpose Gastric cancer ranks as the most common cancer in the world. However, the progresses of its diagnosis and treatment are still not satisfactory. The purpose of this study is to summarize the roles of lncRNAs associated with gastric cancer. Methods We searched lncRNAs associated with gastric c...

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Vydáno v:Journal of cancer research and clinical oncology Ročník 142; číslo 11; s. 2231 - 2237
Hlavní autoři: Sun, Weiliang, Yang, Yunben, Xu, Chunjing, Xie, Yi, Guo, Junming
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2016
Springer Nature B.V
Témata:
Cancer Research
Gastric cancer
Gene expression
Gene Expression Regulation, Neoplastic
Hematology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Review - Cancer Research
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Signal Transduction - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Tumorigenesis
Tumorigenesis
Biological function
Clinical relevance
Long noncoding RNA
Gene expression
Regulatory mechanism
ISSN:0171-5216, 1432-1335, 1432-1335
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Shrnutí:Purpose Gastric cancer ranks as the most common cancer in the world. However, the progresses of its diagnosis and treatment are still not satisfactory. The purpose of this study is to summarize the roles of lncRNAs associated with gastric cancer. Methods We searched lncRNAs associated with gastric cancer in PubMed. Results Long noncoding RNAs (lncRNAs), transcripts larger than 200 nucleotides, regulate gene expression at various levels. They are playing important roles in the occurrence and development of gastric cancer. They are involved in signaling pathways, crosstalk with microRNAs, and affecting metastasis by regulating epithelial-to-mesenchymal transition. By acting as oncogenes or tumor suppressors, lncRNAs contribute to gastric cancer occurrence and development. Several lncRNAs including HOTAIR, HULC, LINC00152, MALAT2, H19, GHET1, and GACAT3 have been demonstrated having oncogene activities, while other lncRNAs including LEIGC, GAS5, and FER1L4 have been thought as tumor suppressors. Conclusions Several lncRNAs from tissue, blood, and gastric juice have shown potential values in gastric cancer diagnosis or prognosis evaluation.
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ISSN:0171-5216
1432-1335
1432-1335
DOI:10.1007/s00432-016-2183-7