Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice

Endogenously administered activated protein C ameliorates diabetic nephropathy (DN) in a protease-activated receptor-1 (PAR-1)-dependent manner, suggesting that PAR-1 activation limits the progression of DN. Activation of PAR-1 in fibroblast-like cells, however, induces proliferation and extracellul...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 33030
Main Authors:	Waasdorp, Maaike, Duitman, JanWillem, Florquin, Sandrine, Spek, C. Arnold
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.09.2016 Nature Publishing Group
Subjects:	45/77 64/60 692/163/2743/137/138 692/4017 692/4022/1585/2759/1419 692/699/1585/2759/1419 82/80 Activated protein C Animals Atrophy Cell Proliferation Collagen (type IV) Cystatin C Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - prevention & control Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - prevention & control Diabetic nephropathy Epithelial cells Extracellular matrix Fibronectin Glucose Humanities and Social Sciences Kidney Tubules - injuries Kidney Tubules - metabolism Kidney Tubules - pathology Kidneys Mesangial cells Mesangial Cells - metabolism Mesangial Cells - pathology Mice Mice, Knockout multidisciplinary Nephropathy Protein C Proteinase Proteinase-activated receptor 1 Proteinuria Receptor, PAR-1 - deficiency Rodents Science Streptozocin
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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