Alterations of the Brain Reward System in Antipsychotic Naïve Schizophrenia Patients
Various schizophrenic symptoms are suggested to be linked to a dysfunction of the brain reward system. Several studies have found alterations in the reward processing in patients with schizophrenia; however, most previous findings might be confounded by medication effects. Thirty-one antipsychotic-n...
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| Vydáno v: | Biological psychiatry (1969) Ročník 71; číslo 10; s. 898 - 905 |
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| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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New York, NY
Elsevier Inc
15.05.2012
Elsevier |
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| ISSN: | 0006-3223, 1873-2402, 1873-2402 |
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| Abstract | Various schizophrenic symptoms are suggested to be linked to a dysfunction of the brain reward system. Several studies have found alterations in the reward processing in patients with schizophrenia; however, most previous findings might be confounded by medication effects.
Thirty-one antipsychotic-naïve schizophrenia patients and 31 age- and gender-matched healthy control subjects were examined with functional magnetic resonance imaging while playing a variant of the monetary incentive delay task. The task variant made it possible to separate overall salience (defined as arousing events) into behavioral salience (events where a predicted reward requires performance) and valence anticipation (the anticipation of a monetarily significant outcome). Furthermore, the evaluation of monetary gain and loss was assessed.
During reward anticipation, patients had a significant attenuation of the activation in ventral tegmentum, ventral striatum, and anterior cingulate cortex during presentation of salient cues. This signal attenuation in ventral striatum was correlated with the degree of positive symptoms. Signal attenuation was most pronounced for behavioral salience and nonsignificant for value anticipation. Furthermore, patients showed a changed activation pattern during outcome evaluation in right prefrontal cortex.
Our results suggest that changes during reward anticipation in schizophrenia are present from the beginning of the disease. This supports a possible involvement of reward disturbances in the pathophysiology of schizophrenia. The most pronounced changes were seen in relation to overall salience. In ventral striatum these changes were associated with the degree of positive symptoms. |
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| AbstractList | Various schizophrenic symptoms are suggested to be linked to a dysfunction of the brain reward system. Several studies have found alterations in the reward processing in patients with schizophrenia; however, most previous findings might be confounded by medication effects.BACKGROUNDVarious schizophrenic symptoms are suggested to be linked to a dysfunction of the brain reward system. Several studies have found alterations in the reward processing in patients with schizophrenia; however, most previous findings might be confounded by medication effects.Thirty-one antipsychotic-naïve schizophrenia patients and 31 age- and gender-matched healthy control subjects were examined with functional magnetic resonance imaging while playing a variant of the monetary incentive delay task. The task variant made it possible to separate overall salience (defined as arousing events) into behavioral salience (events where a predicted reward requires performance) and valence anticipation (the anticipation of a monetarily significant outcome). Furthermore, the evaluation of monetary gain and loss was assessed.METHODSThirty-one antipsychotic-naïve schizophrenia patients and 31 age- and gender-matched healthy control subjects were examined with functional magnetic resonance imaging while playing a variant of the monetary incentive delay task. The task variant made it possible to separate overall salience (defined as arousing events) into behavioral salience (events where a predicted reward requires performance) and valence anticipation (the anticipation of a monetarily significant outcome). Furthermore, the evaluation of monetary gain and loss was assessed.During reward anticipation, patients had a significant attenuation of the activation in ventral tegmentum, ventral striatum, and anterior cingulate cortex during presentation of salient cues. This signal attenuation in ventral striatum was correlated with the degree of positive symptoms. Signal attenuation was most pronounced for behavioral salience and nonsignificant for value anticipation. Furthermore, patients showed a changed activation pattern during outcome evaluation in right prefrontal cortex.RESULTSDuring reward anticipation, patients had a significant attenuation of the activation in ventral tegmentum, ventral striatum, and anterior cingulate cortex during presentation of salient cues. This signal attenuation in ventral striatum was correlated with the degree of positive symptoms. Signal attenuation was most pronounced for behavioral salience and nonsignificant for value anticipation. Furthermore, patients showed a changed activation pattern during outcome evaluation in right prefrontal cortex.Our results suggest that changes during reward anticipation in schizophrenia are present from the beginning of the disease. This supports a possible involvement of reward disturbances in the pathophysiology of schizophrenia. The most pronounced changes were seen in relation to overall salience. In ventral striatum these changes were associated with the degree of positive symptoms.CONCLUSIONOur results suggest that changes during reward anticipation in schizophrenia are present from the beginning of the disease. This supports a possible involvement of reward disturbances in the pathophysiology of schizophrenia. The most pronounced changes were seen in relation to overall salience. In ventral striatum these changes were associated with the degree of positive symptoms. BackgroundVarious schizophrenic symptoms are suggested to be linked to a dysfunction of the brain reward system. Several studies have found alterations in the reward processing in patients with schizophrenia; however, most previous findings might be confounded by medication effects. MethodsThirty-one antipsychotic-naïve schizophrenia patients and 31 age- and gender-matched healthy control subjects were examined with functional magnetic resonance imaging while playing a variant of the monetary incentive delay task. The task variant made it possible to separate overall salience (defined as arousing events) into behavioral salience (events where a predicted reward requires performance) and valence anticipation (the anticipation of a monetarily significant outcome) . Furthermore, the evaluation of monetary gain and loss was assessed. ResultsDuring reward anticipation, patients had a significant attenuation of the activation in ventral tegmentum, ventral striatum, and anterior cingulate cortex during presentation of salient cues. This signal attenuation in ventral striatum was correlated with the degree of positive symptoms. Signal attenuation was most pronounced for behavioral salience and nonsignificant for value anticipation. Furthermore, patients showed a changed activation pattern during outcome evaluation in right prefrontal cortex. ConclusionOur results suggest that changes during reward anticipation in schizophrenia are present from the beginning of the disease. This supports a possible involvement of reward disturbances in the pathophysiology of schizophrenia. The most pronounced changes were seen in relation to overall salience. In ventral striatum these changes were associated with the degree of positive symptoms. Various schizophrenic symptoms are suggested to be linked to a dysfunction of the brain reward system. Several studies have found alterations in the reward processing in patients with schizophrenia; however, most previous findings might be confounded by medication effects. Thirty-one antipsychotic-naïve schizophrenia patients and 31 age- and gender-matched healthy control subjects were examined with functional magnetic resonance imaging while playing a variant of the monetary incentive delay task. The task variant made it possible to separate overall salience (defined as arousing events) into behavioral salience (events where a predicted reward requires performance) and valence anticipation (the anticipation of a monetarily significant outcome). Furthermore, the evaluation of monetary gain and loss was assessed. During reward anticipation, patients had a significant attenuation of the activation in ventral tegmentum, ventral striatum, and anterior cingulate cortex during presentation of salient cues. This signal attenuation in ventral striatum was correlated with the degree of positive symptoms. Signal attenuation was most pronounced for behavioral salience and nonsignificant for value anticipation. Furthermore, patients showed a changed activation pattern during outcome evaluation in right prefrontal cortex. Our results suggest that changes during reward anticipation in schizophrenia are present from the beginning of the disease. This supports a possible involvement of reward disturbances in the pathophysiology of schizophrenia. The most pronounced changes were seen in relation to overall salience. In ventral striatum these changes were associated with the degree of positive symptoms. |
| Author | Rostrup, Egill Glenthøj, Birte Lublin, Henrik Nielsen, Mette Ødegaard Wulff, Sanne Bak, Nikolaj Kapur, Shitij |
| Author_xml | – sequence: 1 givenname: Mette Ødegaard surname: Nielsen fullname: Nielsen, Mette Ødegaard email: mette@cnsr.dk organization: Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Center for Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Glostrup, Denmark – sequence: 2 givenname: Egill surname: Rostrup fullname: Rostrup, Egill organization: Functional Imaging Unit, Copenhagen University Hospital, Glostrup, Denmark – sequence: 3 givenname: Sanne surname: Wulff fullname: Wulff, Sanne organization: Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Center for Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Glostrup, Denmark – sequence: 4 givenname: Nikolaj surname: Bak fullname: Bak, Nikolaj organization: Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Center for Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Glostrup, Denmark – sequence: 5 givenname: Henrik surname: Lublin fullname: Lublin, Henrik organization: Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Center for Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Glostrup, Denmark – sequence: 6 givenname: Shitij surname: Kapur fullname: Kapur, Shitij organization: Institute of Psychiatry, Kings College London, United Kingdom – sequence: 7 givenname: Birte surname: Glenthøj fullname: Glenthøj, Birte organization: Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Center for Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Glostrup, Denmark |
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| Cites_doi | 10.1016/j.biopsych.2006.01.010 10.1016/j.euroneuro.2009.11.010 10.1146/annurev.neuro.30.051606.094334 10.1177/070674370505000806 10.1176/appi.ajp.160.10.1775 10.1007/s00213-006-0578-x 10.1038/npp.2010.126 10.1093/schbul/sbm049 10.1016/j.biopsych.2008.12.016 10.1016/j.biopsych.2009.10.020 10.1016/j.neuroimage.2007.12.040 10.1097/00001756-200112040-00016 10.1093/cercor/bhj004 10.1016/j.neuroimage.2009.07.022 10.1073/pnas.0802127105 10.1073/pnas.91.24.11651 10.1038/sj.mp.4002157 10.1073/pnas.97.14.8104 10.1016/S1053-8119(03)00381-1 10.1126/science.275.5306.1593 10.1176/ajp.155.6.761 10.1016/S0896-6273(04)00183-7 10.1055/s-2006-931483 10.1038/sj.npp.1300679 10.2174/138161209788957528 10.1016/S0140-6736(95)91801-9 10.1016/S0006-3223(99)00109-2 10.1073/pnas.93.17.9235 10.1177/0269881110367731 10.1016/j.neuroimage.2005.07.051 10.1038/npp.2010.154 10.1093/schbul/sbq031 10.1016/j.neuron.2004.06.030 10.1016/j.neuroimage.2005.06.056 10.1007/s00213-009-1586-4 10.1016/S0920-9964(96)00102-8 10.1093/schbul/sbq068 10.1016/S0166-2236(98)01373-3 10.1016/j.pneurobio.2004.05.006 10.1016/j.neuroimage.2007.08.009 10.1093/brain/awm173 10.1016/0028-3932(71)90067-4 10.1176/appi.ajp.2010.09081215 10.1093/schbul/sbp006 10.1016/0165-0173(93)90013-P 10.1016/j.coph.2008.12.014 10.1093/schbul/13.2.261 10.1016/j.schres.2009.11.007 10.1038/nn804 10.1001/archgenpsychiatry.2009.176 10.1038/sj.npp.1301242 10.1073/pnas.94.6.2569 10.1038/35083500 10.1016/j.schres.2007.03.008 10.1016/j.jpsychires.2009.12.008 10.1016/S0924-9338(02)00628-4 10.1002/hbm.20948 10.1016/S0166-2236(03)00233-9 10.1001/archgenpsychiatry.2010.10 10.1016/S0306-4522(00)00019-1 10.1176/appi.ajp.160.1.13 10.1523/JNEUROSCI.21-16-j0002.2001 |
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| PublicationDateYYYYMMDD | 2012-05-15 |
| PublicationDate_xml | – month: 05 year: 2012 text: 2012-05-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States |
| PublicationTitle | Biological psychiatry (1969) |
| PublicationTitleAlternate | Biol Psychiatry |
| PublicationYear | 2012 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Lindstrom, Gefvert, Hagberg, Lundberg, Bergstrom, Hartvig (bib19) 1999; 46 Seamans, Yang (bib12) 2004; 74 da Silva, Schmitz, Figee, Abeling, Hasler, van der Meer (bib30) 2011; 25 Picard, Amado, Mouchet-Mages, Olie, Krebs (bib58) 2008; 34 Redgrave, Prescott, Gurney (bib2) 1999; 22 Gard, Kring, Gard, Horan, Green (bib54) 2007; 93 Simon, Biller, Walther, Roesch-Ely, Stippich, Weisbrod (bib35) 2010; 118 Juckel, Schlagenhauf, Koslowski, Wustenberg, Villringer, Knutson (bib31) 2006; 29 Berridge, Robinson (bib27) 2003; 26 Dreher, Meyer-Lindenberg, Kohn, Berman (bib29) 2008; 105 Paradiso, Andreasen, Crespo-Facorro, O'Leary, Watkins, Boles Ponto (bib33) 2003; 160 Walter, Kammerer, Frasch, Spitzer, Abler (bib45) 2009; 206 Harvey, Armony, Malla, Lepage (bib37) 2010; 44 Dreher, Kohn, Berman (bib43) 2006; 16 Meyer-Lindenberg, Miletich, Kohn, Esposito, Carson, Quarantelli (bib25) 2002; 5 Rasmussen, Erritzoe, Andersen, Ebdrup, Aggernaes, Oranje (bib13) 2010; 67 Heinz, Schlagenhauf (bib38) 2010; 36 Knutson, Adams, Fong, Hommer (bib42) 2001; 21 Barch, Dowd (bib10) 2010; 36 Howes, Kapur (bib15) 2009; 35 Schlagenhauf, Sterzer, Schmack, Ballmaier, Rapp, Wrase (bib32) 2009; 65 Dowd, Barch (bib55) 2010; 67 Oldfield (bib41) 1971; 9 Abi-Dargham, Gil, Krystal, Baldwin, Seibyl, Bowers (bib21) 1998; 155 Cooper, Knutson (bib39) 2008; 39 Robinson, Berridge (bib51) 1993; 18 Nestor, Hester, Garavan (bib60) 2010; 49 Wallis (bib9) 2007; 30 Ursu, Kring, Gard, Minzenberg, Yoon, Ragland (bib56) 2011; 168 Kozink, Kollins, McClernon (bib61) 2010; 35 Berridge, Robinson, Aldridge (bib1) 2009; 9 Breier, Su, Saunders, Carson, Kolachana, de Bartolomeis (bib22) 1997; 94 Kay, Fiszbein, Opler (bib40) 1987; 13 Kegeles, Abi-Dargham, Frankle, Gil, Cooper, Slifstein (bib48) 2010; 67 Waelti, Dickinson, Schultz (bib26) 2001; 412 Costa, Lang, Sabatinelli, Versace, Bradley (bib8) 2010; 31 Knutson, Bjork, Fong, Hommer, Mattay, Weinberger (bib28) 2004; 43 van Hell, Vink, Ossewaarde, Jager, Kahn, Ramsey (bib59) 2010; 20 Murray, Corlett, Clark, Pessiglione, Blackwell, Honey (bib46) 2008; 13 Corlett, Murray, Honey, Aitken, Shanks, Robbins (bib57) 2007; 130 Howes, Egerton, Allan, McGuire, Stokes, Kapur (bib49) 2009; 15 Plailly, d'Amato, Saoud, Royet (bib34) 2006; 29 Friedman, Turner, Stern, Mathalon, Trondsen, Potkin (bib62) 2008; 40 Taylor, Phan, Britton, Liberzon (bib50) 2005; 30 Berridge (bib4) 2007; 191 Knutson, Fong, Adams, Varner, Hommer (bib7) 2001; 12 Abi-Dargham, Rodenhiser, Printz, Zea-Ponce, Gil, Kegeles (bib47) 2000; 97 Reith, Benkelfat, Sherwin, Yasuhara, Kuwabara, Andermann (bib16) 1994; 91 Carlsson (bib11) 2006; 39 Hietala, Syvalahti, Vuorio, Rakkolainen, Bergman, Haaparanta (bib17) 1995; 346 Schultz, Dayan, Montague (bib3) 1997; 275 Kirsch, Schienle, Stark, Sammer, Blecker, Walter (bib44) 2003; 20 Agid, Mamo, Ginovart, Vitcu, Wilson, Zipursky (bib23) 2007; 32 Zink, Pagnoni, Martin-Skurski, Chappelow, Berns (bib5) 2004; 42 Horvitz (bib6) 2000; 96 Laruelle, Abi-Dargham, van Dyck, Gil, D'Souza, Erdos (bib20) 1996; 93 Dao-Castellana, Paillere-Martinot, Hantraye, Attar-Levy, Remy, Crouzel (bib18) 1997; 23 Zipursky, Christensen, Daskalakis, Epstein, Roy, Furimsky (bib24) 2005; 50 Waltz, Schweitzer, Ross, Kurup, Salmeron, Rose (bib36) 2010; 35 Glenthoj, Mackeprang, Svarer, Rasmussen, Pinborg, Friberg (bib14) 2006; 60 Kapur (bib53) 2003; 160 Heinz (bib52) 2002; 17 Oldfield (10.1016/j.biopsych.2012.02.007_bib41) 1971; 9 Heinz (10.1016/j.biopsych.2012.02.007_bib52) 2002; 17 Glenthoj (10.1016/j.biopsych.2012.02.007_bib14) 2006; 60 Rasmussen (10.1016/j.biopsych.2012.02.007_bib13) 2010; 67 Walter (10.1016/j.biopsych.2012.02.007_bib45) 2009; 206 Abi-Dargham (10.1016/j.biopsych.2012.02.007_bib47) 2000; 97 Knutson (10.1016/j.biopsych.2012.02.007_bib42) 2001; 21 Plailly (10.1016/j.biopsych.2012.02.007_bib34) 2006; 29 Schultz (10.1016/j.biopsych.2012.02.007_bib3) 1997; 275 Redgrave (10.1016/j.biopsych.2012.02.007_bib2) 1999; 22 Heinz (10.1016/j.biopsych.2012.02.007_bib38) 2010; 36 Kapur (10.1016/j.biopsych.2012.02.007_bib53) 2003; 160 Dreher (10.1016/j.biopsych.2012.02.007_bib29) 2008; 105 Barch (10.1016/j.biopsych.2012.02.007_bib10) 2010; 36 Laruelle (10.1016/j.biopsych.2012.02.007_bib20) 1996; 93 van Hell (10.1016/j.biopsych.2012.02.007_bib59) 2010; 20 Waelti (10.1016/j.biopsych.2012.02.007_bib26) 2001; 412 Cooper (10.1016/j.biopsych.2012.02.007_bib39) 2008; 39 Berridge (10.1016/j.biopsych.2012.02.007_bib1) 2009; 9 Costa (10.1016/j.biopsych.2012.02.007_bib8) 2010; 31 Reith (10.1016/j.biopsych.2012.02.007_bib16) 1994; 91 Zink (10.1016/j.biopsych.2012.02.007_bib5) 2004; 42 Murray (10.1016/j.biopsych.2012.02.007_bib46) 2008; 13 Kegeles (10.1016/j.biopsych.2012.02.007_bib48) 2010; 67 Picard (10.1016/j.biopsych.2012.02.007_bib58) 2008; 34 Kay (10.1016/j.biopsych.2012.02.007_bib40) 1987; 13 Howes (10.1016/j.biopsych.2012.02.007_bib15) 2009; 35 Lindstrom (10.1016/j.biopsych.2012.02.007_bib19) 1999; 46 Knutson (10.1016/j.biopsych.2012.02.007_bib7) 2001; 12 Taylor (10.1016/j.biopsych.2012.02.007_bib50) 2005; 30 Waltz (10.1016/j.biopsych.2012.02.007_bib36) 2010; 35 Nestor (10.1016/j.biopsych.2012.02.007_bib60) 2010; 49 Gard (10.1016/j.biopsych.2012.02.007_bib54) 2007; 93 Robinson (10.1016/j.biopsych.2012.02.007_bib51) 1993; 18 da Silva (10.1016/j.biopsych.2012.02.007_bib30) 2011; 25 Dowd (10.1016/j.biopsych.2012.02.007_bib55) 2010; 67 Howes (10.1016/j.biopsych.2012.02.007_bib49) 2009; 15 Horvitz (10.1016/j.biopsych.2012.02.007_bib6) 2000; 96 Breier (10.1016/j.biopsych.2012.02.007_bib22) 1997; 94 Meyer-Lindenberg (10.1016/j.biopsych.2012.02.007_bib25) 2002; 5 Kirsch (10.1016/j.biopsych.2012.02.007_bib44) 2003; 20 Agid (10.1016/j.biopsych.2012.02.007_bib23) 2007; 32 Schlagenhauf (10.1016/j.biopsych.2012.02.007_bib32) 2009; 65 Simon (10.1016/j.biopsych.2012.02.007_bib35) 2010; 118 Dreher (10.1016/j.biopsych.2012.02.007_bib43) 2006; 16 Abi-Dargham (10.1016/j.biopsych.2012.02.007_bib21) 1998; 155 Friedman (10.1016/j.biopsych.2012.02.007_bib62) 2008; 40 Seamans (10.1016/j.biopsych.2012.02.007_bib12) 2004; 74 Paradiso (10.1016/j.biopsych.2012.02.007_bib33) 2003; 160 Hietala (10.1016/j.biopsych.2012.02.007_bib17) 1995; 346 Ursu (10.1016/j.biopsych.2012.02.007_bib56) 2011; 168 Zipursky (10.1016/j.biopsych.2012.02.007_bib24) 2005; 50 Berridge (10.1016/j.biopsych.2012.02.007_bib27) 2003; 26 Berridge (10.1016/j.biopsych.2012.02.007_bib4) 2007; 191 Carlsson (10.1016/j.biopsych.2012.02.007_bib11) 2006; 39 Wallis (10.1016/j.biopsych.2012.02.007_bib9) 2007; 30 Juckel (10.1016/j.biopsych.2012.02.007_bib31) 2006; 29 Corlett (10.1016/j.biopsych.2012.02.007_bib57) 2007; 130 Kozink (10.1016/j.biopsych.2012.02.007_bib61) 2010; 35 Knutson (10.1016/j.biopsych.2012.02.007_bib28) 2004; 43 Harvey (10.1016/j.biopsych.2012.02.007_bib37) 2010; 44 Dao-Castellana (10.1016/j.biopsych.2012.02.007_bib18) 1997; 23 |
| References_xml | – volume: 275 start-page: 1593 year: 1997 end-page: 1599 ident: bib3 article-title: A neural substrate of prediction and reward publication-title: Science – volume: 44 start-page: 707 year: 2010 end-page: 716 ident: bib37 article-title: Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia publication-title: J Psychiatr Res – volume: 49 start-page: 1133 year: 2010 end-page: 1143 ident: bib60 article-title: Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users publication-title: Neuroimage – volume: 40 start-page: 1181 year: 2008 end-page: 1194 ident: bib62 article-title: Chronic smoking and the BOLD response to a visual activation task and a breath hold task in patients with schizophrenia and healthy controls publication-title: Neuroimage – volume: 93 start-page: 253 year: 2007 end-page: 260 ident: bib54 article-title: Anhedonia in schizophrenia: Distinctions between anticipatory and consummatory pleasure publication-title: Schizophr Res – volume: 46 start-page: 681 year: 1999 end-page: 688 ident: bib19 article-title: Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET publication-title: Biol Psychiatry – volume: 155 start-page: 761 year: 1998 end-page: 767 ident: bib21 article-title: Increased striatal dopamine transmission in schizophrenia: Confirmation in a second cohort publication-title: Am J Psychiatry – volume: 43 start-page: 261 year: 2004 end-page: 269 ident: bib28 article-title: Amphetamine modulates human incentive processing publication-title: Neuron – volume: 160 start-page: 1775 year: 2003 end-page: 1783 ident: bib33 article-title: Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomography publication-title: Am J Psychiatry – volume: 13 start-page: 239 year: 2008 ident: bib46 article-title: Substantia nigra/ventral tegmental reward prediction error disruption in psychosis publication-title: Mol Psychiatry – volume: 160 start-page: 13 year: 2003 end-page: 23 ident: bib53 article-title: Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia publication-title: Am J Psychiatry – volume: 67 start-page: 231 year: 2010 end-page: 239 ident: bib48 article-title: Increased synaptic dopamine function in associative regions of the striatum in schizophrenia publication-title: Arch Gen Psychiatry – volume: 67 start-page: 902 year: 2010 end-page: 911 ident: bib55 article-title: Anhedonia and emotional experience in schizophrenia: Neural and behavioral indicators publication-title: Biol Psychiatry – volume: 20 start-page: 153 year: 2010 end-page: 163 ident: bib59 article-title: Chronic effects of cannabis use on the human reward system: An fMRI study publication-title: Eur Neuropsychopharmacol – volume: 16 start-page: 561 year: 2006 end-page: 573 ident: bib43 article-title: Neural coding of distinct statistical properties of reward information in humans publication-title: Cereb Cortex – volume: 36 start-page: 472 year: 2010 end-page: 485 ident: bib38 article-title: Dopaminergic dysfunction in schizophrenia: Salience attribution revisited publication-title: Schizophr Bull – volume: 34 start-page: 155 year: 2008 end-page: 172 ident: bib58 article-title: The role of the cerebellum in schizophrenia: An update of clinical, cognitive, and functional evidences publication-title: Schizophr Bull – volume: 15 start-page: 2550 year: 2009 end-page: 2559 ident: bib49 article-title: Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: Insights from PET and SPECT imaging publication-title: Curr Pharm Des – volume: 35 start-page: 2600 year: 2010 end-page: 2606 ident: bib61 article-title: Smoking withdrawal modulates right inferior frontal cortex but not presupplementary motor area activation during inhibitory control publication-title: Neuropsychopharmacology – volume: 32 start-page: 1209 year: 2007 end-page: 1215 ident: bib23 article-title: Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response—a double-blind PET study in schizophrenia publication-title: Neuropsychopharmacology – volume: 29 start-page: 302 year: 2006 end-page: 313 ident: bib34 article-title: Left temporo-limbic and orbital dysfunction in schizophrenia during odor familiarity and hedonicity judgments publication-title: Neuroimage – volume: 35 start-page: 2427 year: 2010 end-page: 2439 ident: bib36 article-title: Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia publication-title: Neuropsychopharmacology – volume: 65 start-page: 1032 year: 2009 end-page: 1039 ident: bib32 article-title: Reward feedback alterations in unmedicated schizophrenia patients: Relevance for delusions publication-title: Biol Psychiatry – volume: 31 start-page: 1446 year: 2010 end-page: 1457 ident: bib8 article-title: Emotional imagery: Assessing pleasure and arousal in the brain's reward circuitry publication-title: Hum Brain Mapp – volume: 346 start-page: 1130 year: 1995 end-page: 1131 ident: bib17 article-title: Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients publication-title: Lancet – volume: 118 start-page: 154 year: 2010 end-page: 161 ident: bib35 article-title: Neural correlates of reward processing in schizophrenia—relationship to apathy and depression publication-title: Schizophr Res – volume: 36 start-page: 919 year: 2010 end-page: 934 ident: bib10 article-title: Goal representations and motivational drive in schizophrenia: The role of prefrontal-striatal interactions publication-title: Schizophr Bull – volume: 23 start-page: 167 year: 1997 end-page: 174 ident: bib18 article-title: Presynaptic dopaminergic function in the striatum of schizophrenic patients publication-title: Schizophr Res – volume: 12 start-page: 3683 year: 2001 end-page: 3687 ident: bib7 article-title: Dissociation of reward anticipation and outcome with event-related fMRI publication-title: Neuroreport – volume: 94 start-page: 2569 year: 1997 end-page: 2574 ident: bib22 article-title: Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method publication-title: Proc Natl Acad Sci U S A – volume: 412 start-page: 43 year: 2001 end-page: 48 ident: bib26 article-title: Dopamine responses comply with basic assumptions of formal learning theory publication-title: Nature – volume: 206 start-page: 121 year: 2009 end-page: 132 ident: bib45 article-title: Altered reward functions in patients on atypical antipsychotic medication in line with the revised dopamine hypothesis of schizophrenia publication-title: Psychopharmacology (Berl) – volume: 25 start-page: 538 year: 2011 end-page: 549 ident: bib30 article-title: Dopaminergic modulation of the human reward system: A placebo-controlled dopamine depletion fMRI study publication-title: J Psychopharmacol – volume: 22 start-page: 146 year: 1999 end-page: 151 ident: bib2 article-title: Is the short-latency dopamine response too short to signal reward error? publication-title: Trends Neurosci – volume: 17 start-page: 9 year: 2002 end-page: 16 ident: bib52 article-title: Dopaminergic dysfunction in alcoholism and schizophrenia—psychopathological and behavioral correlates publication-title: Eur Psychiatry – volume: 105 start-page: 15106 year: 2008 end-page: 15111 ident: bib29 article-title: Age-related changes in midbrain dopaminergic regulation of the human reward system publication-title: Proc Natl Acad Sci U S A – volume: 130 start-page: 2387 year: 2007 end-page: 2400 ident: bib57 article-title: Disrupted prediction-error signal in psychosis: Evidence for an associative account of delusions publication-title: Brain – volume: 74 start-page: 1 year: 2004 end-page: 58 ident: bib12 article-title: The principal features and mechanisms of dopamine modulation in the prefrontal cortex publication-title: Prog Neurobiol – volume: 96 start-page: 651 year: 2000 end-page: 656 ident: bib6 article-title: Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events publication-title: Neuroscience – volume: 21 start-page: RC159 year: 2001 ident: bib42 article-title: Anticipation of increasing monetary reward selectively recruits nucleus accumbens publication-title: J Neurosci – volume: 18 start-page: 247 year: 1993 end-page: 291 ident: bib51 article-title: The neural basis of drug craving: An incentive-sensitization theory of addiction publication-title: Brain Res Brain Res Rev – volume: 5 start-page: 267 year: 2002 end-page: 271 ident: bib25 article-title: Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia publication-title: Nat Neurosci – volume: 9 start-page: 65 year: 2009 end-page: 73 ident: bib1 article-title: Dissecting components of reward: ‘liking’, ‘wanting’, and learning publication-title: Curr Opin Pharmacol – volume: 35 start-page: 549 year: 2009 end-page: 562 ident: bib15 article-title: The dopamine hypothesis of schizophrenia: Version III—the final common pathway publication-title: Schizophr Bull – volume: 20 start-page: 1086 year: 2003 end-page: 1095 ident: bib44 article-title: Anticipation of reward in a nonaversive differential conditioning paradigm and the brain reward system: An event-related fMRI study publication-title: Neuroimage – volume: 29 start-page: 409 year: 2006 end-page: 416 ident: bib31 article-title: Dysfunction of ventral striatal reward prediction in schizophrenia publication-title: Neuroimage – volume: 42 start-page: 509 year: 2004 end-page: 517 ident: bib5 article-title: Human striatal responses to monetary reward depend on saliency publication-title: Neuron – volume: 93 start-page: 9235 year: 1996 end-page: 9240 ident: bib20 article-title: Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects publication-title: Proc Natl Acad Sci U S A – volume: 168 start-page: 276 year: 2011 end-page: 285 ident: bib56 article-title: Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia publication-title: Am J Psychiatry – volume: 13 start-page: 261 year: 1987 end-page: 276 ident: bib40 article-title: The positive and negative syndrome scale (PANSS) for schizophrenia publication-title: Schizophr Bull – volume: 191 start-page: 391 year: 2007 end-page: 431 ident: bib4 article-title: The debate over dopamine's role in reward: The case for incentive salience publication-title: Psychopharmacology (Berl) – volume: 67 start-page: 9 year: 2010 end-page: 16 ident: bib13 article-title: Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia publication-title: Arch Gen Psychiatry – volume: 30 start-page: 984 year: 2005 end-page: 995 ident: bib50 article-title: Neural response to emotional salience in schizophrenia publication-title: Neuropsychopharmacology – volume: 9 start-page: 97 year: 1971 end-page: 113 ident: bib41 article-title: The assessment and analysis of handedness: The Edinburgh inventory publication-title: Neuropsychologia – volume: 97 start-page: 8104 year: 2000 end-page: 8109 ident: bib47 article-title: Increased baseline occupancy of D2 receptors by dopamine in schizophrenia publication-title: Proc Natl Acad Sci U S A – volume: 30 start-page: 31 year: 2007 end-page: 56 ident: bib9 article-title: Orbitofrontal cortex and its contribution to decision-making publication-title: Annu Rev Neurosci – volume: 39 start-page: 538 year: 2008 end-page: 547 ident: bib39 article-title: Valence and salience contribute to nucleus accumbens activation publication-title: Neuroimage – volume: 39 start-page: S10 year: 2006 end-page: S14 ident: bib11 article-title: The neurochemical circuitry of schizophrenia publication-title: Pharmacopsychiatry – volume: 50 start-page: 462 year: 2005 end-page: 469 ident: bib24 article-title: Treatment response to olanzapine and haloperidol and its association with dopamine D receptor occupancy in first-episode psychosis publication-title: Can J Psychiatry – volume: 60 start-page: 621 year: 2006 end-page: 629 ident: bib14 article-title: Frontal dopamine D(2/3) receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender publication-title: Biol Psychiatry – volume: 26 start-page: 507 year: 2003 end-page: 513 ident: bib27 article-title: Parsing reward publication-title: Trends Neurosci – volume: 91 start-page: 11651 year: 1994 end-page: 11654 ident: bib16 article-title: Elevated dopa decarboxylase activity in living brain of patients with psychosis publication-title: Proc Natl Acad Sci U S A – volume: 60 start-page: 621 year: 2006 ident: 10.1016/j.biopsych.2012.02.007_bib14 article-title: Frontal dopamine D(2/3) receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2006.01.010 – volume: 20 start-page: 153 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib59 article-title: Chronic effects of cannabis use on the human reward system: An fMRI study publication-title: Eur Neuropsychopharmacol doi: 10.1016/j.euroneuro.2009.11.010 – volume: 30 start-page: 31 year: 2007 ident: 10.1016/j.biopsych.2012.02.007_bib9 article-title: Orbitofrontal cortex and its contribution to decision-making publication-title: Annu Rev Neurosci doi: 10.1146/annurev.neuro.30.051606.094334 – volume: 50 start-page: 462 year: 2005 ident: 10.1016/j.biopsych.2012.02.007_bib24 article-title: Treatment response to olanzapine and haloperidol and its association with dopamine D receptor occupancy in first-episode psychosis publication-title: Can J Psychiatry doi: 10.1177/070674370505000806 – volume: 160 start-page: 1775 year: 2003 ident: 10.1016/j.biopsych.2012.02.007_bib33 article-title: Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomography publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.160.10.1775 – volume: 191 start-page: 391 year: 2007 ident: 10.1016/j.biopsych.2012.02.007_bib4 article-title: The debate over dopamine's role in reward: The case for incentive salience publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-006-0578-x – volume: 35 start-page: 2427 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib36 article-title: Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.126 – volume: 34 start-page: 155 year: 2008 ident: 10.1016/j.biopsych.2012.02.007_bib58 article-title: The role of the cerebellum in schizophrenia: An update of clinical, cognitive, and functional evidences publication-title: Schizophr Bull doi: 10.1093/schbul/sbm049 – volume: 65 start-page: 1032 year: 2009 ident: 10.1016/j.biopsych.2012.02.007_bib32 article-title: Reward feedback alterations in unmedicated schizophrenia patients: Relevance for delusions publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2008.12.016 – volume: 67 start-page: 902 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib55 article-title: Anhedonia and emotional experience in schizophrenia: Neural and behavioral indicators publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2009.10.020 – volume: 40 start-page: 1181 year: 2008 ident: 10.1016/j.biopsych.2012.02.007_bib62 article-title: Chronic smoking and the BOLD response to a visual activation task and a breath hold task in patients with schizophrenia and healthy controls publication-title: Neuroimage doi: 10.1016/j.neuroimage.2007.12.040 – volume: 12 start-page: 3683 year: 2001 ident: 10.1016/j.biopsych.2012.02.007_bib7 article-title: Dissociation of reward anticipation and outcome with event-related fMRI publication-title: Neuroreport doi: 10.1097/00001756-200112040-00016 – volume: 16 start-page: 561 year: 2006 ident: 10.1016/j.biopsych.2012.02.007_bib43 article-title: Neural coding of distinct statistical properties of reward information in humans publication-title: Cereb Cortex doi: 10.1093/cercor/bhj004 – volume: 49 start-page: 1133 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib60 article-title: Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.07.022 – volume: 105 start-page: 15106 year: 2008 ident: 10.1016/j.biopsych.2012.02.007_bib29 article-title: Age-related changes in midbrain dopaminergic regulation of the human reward system publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0802127105 – volume: 91 start-page: 11651 year: 1994 ident: 10.1016/j.biopsych.2012.02.007_bib16 article-title: Elevated dopa decarboxylase activity in living brain of patients with psychosis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.91.24.11651 – volume: 13 start-page: 239 year: 2008 ident: 10.1016/j.biopsych.2012.02.007_bib46 article-title: Substantia nigra/ventral tegmental reward prediction error disruption in psychosis publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4002157 – volume: 97 start-page: 8104 year: 2000 ident: 10.1016/j.biopsych.2012.02.007_bib47 article-title: Increased baseline occupancy of D2 receptors by dopamine in schizophrenia publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.97.14.8104 – volume: 20 start-page: 1086 year: 2003 ident: 10.1016/j.biopsych.2012.02.007_bib44 article-title: Anticipation of reward in a nonaversive differential conditioning paradigm and the brain reward system: An event-related fMRI study publication-title: Neuroimage doi: 10.1016/S1053-8119(03)00381-1 – volume: 275 start-page: 1593 year: 1997 ident: 10.1016/j.biopsych.2012.02.007_bib3 article-title: A neural substrate of prediction and reward publication-title: Science doi: 10.1126/science.275.5306.1593 – volume: 155 start-page: 761 year: 1998 ident: 10.1016/j.biopsych.2012.02.007_bib21 article-title: Increased striatal dopamine transmission in schizophrenia: Confirmation in a second cohort publication-title: Am J Psychiatry doi: 10.1176/ajp.155.6.761 – volume: 42 start-page: 509 year: 2004 ident: 10.1016/j.biopsych.2012.02.007_bib5 article-title: Human striatal responses to monetary reward depend on saliency publication-title: Neuron doi: 10.1016/S0896-6273(04)00183-7 – volume: 39 start-page: S10 issue: suppl 1 year: 2006 ident: 10.1016/j.biopsych.2012.02.007_bib11 article-title: The neurochemical circuitry of schizophrenia publication-title: Pharmacopsychiatry doi: 10.1055/s-2006-931483 – volume: 30 start-page: 984 year: 2005 ident: 10.1016/j.biopsych.2012.02.007_bib50 article-title: Neural response to emotional salience in schizophrenia publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300679 – volume: 15 start-page: 2550 year: 2009 ident: 10.1016/j.biopsych.2012.02.007_bib49 article-title: Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: Insights from PET and SPECT imaging publication-title: Curr Pharm Des doi: 10.2174/138161209788957528 – volume: 346 start-page: 1130 year: 1995 ident: 10.1016/j.biopsych.2012.02.007_bib17 article-title: Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients publication-title: Lancet doi: 10.1016/S0140-6736(95)91801-9 – volume: 46 start-page: 681 year: 1999 ident: 10.1016/j.biopsych.2012.02.007_bib19 article-title: Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(99)00109-2 – volume: 93 start-page: 9235 year: 1996 ident: 10.1016/j.biopsych.2012.02.007_bib20 article-title: Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.93.17.9235 – volume: 25 start-page: 538 year: 2011 ident: 10.1016/j.biopsych.2012.02.007_bib30 article-title: Dopaminergic modulation of the human reward system: A placebo-controlled dopamine depletion fMRI study publication-title: J Psychopharmacol doi: 10.1177/0269881110367731 – volume: 29 start-page: 409 year: 2006 ident: 10.1016/j.biopsych.2012.02.007_bib31 article-title: Dysfunction of ventral striatal reward prediction in schizophrenia publication-title: Neuroimage doi: 10.1016/j.neuroimage.2005.07.051 – volume: 35 start-page: 2600 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib61 article-title: Smoking withdrawal modulates right inferior frontal cortex but not presupplementary motor area activation during inhibitory control publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.154 – volume: 36 start-page: 472 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib38 article-title: Dopaminergic dysfunction in schizophrenia: Salience attribution revisited publication-title: Schizophr Bull doi: 10.1093/schbul/sbq031 – volume: 43 start-page: 261 year: 2004 ident: 10.1016/j.biopsych.2012.02.007_bib28 article-title: Amphetamine modulates human incentive processing publication-title: Neuron doi: 10.1016/j.neuron.2004.06.030 – volume: 29 start-page: 302 year: 2006 ident: 10.1016/j.biopsych.2012.02.007_bib34 article-title: Left temporo-limbic and orbital dysfunction in schizophrenia during odor familiarity and hedonicity judgments publication-title: Neuroimage doi: 10.1016/j.neuroimage.2005.06.056 – volume: 206 start-page: 121 year: 2009 ident: 10.1016/j.biopsych.2012.02.007_bib45 article-title: Altered reward functions in patients on atypical antipsychotic medication in line with the revised dopamine hypothesis of schizophrenia publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-009-1586-4 – volume: 23 start-page: 167 year: 1997 ident: 10.1016/j.biopsych.2012.02.007_bib18 article-title: Presynaptic dopaminergic function in the striatum of schizophrenic patients publication-title: Schizophr Res doi: 10.1016/S0920-9964(96)00102-8 – volume: 36 start-page: 919 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib10 article-title: Goal representations and motivational drive in schizophrenia: The role of prefrontal-striatal interactions publication-title: Schizophr Bull doi: 10.1093/schbul/sbq068 – volume: 22 start-page: 146 year: 1999 ident: 10.1016/j.biopsych.2012.02.007_bib2 article-title: Is the short-latency dopamine response too short to signal reward error? publication-title: Trends Neurosci doi: 10.1016/S0166-2236(98)01373-3 – volume: 74 start-page: 1 year: 2004 ident: 10.1016/j.biopsych.2012.02.007_bib12 article-title: The principal features and mechanisms of dopamine modulation in the prefrontal cortex publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2004.05.006 – volume: 39 start-page: 538 year: 2008 ident: 10.1016/j.biopsych.2012.02.007_bib39 article-title: Valence and salience contribute to nucleus accumbens activation publication-title: Neuroimage doi: 10.1016/j.neuroimage.2007.08.009 – volume: 130 start-page: 2387 year: 2007 ident: 10.1016/j.biopsych.2012.02.007_bib57 article-title: Disrupted prediction-error signal in psychosis: Evidence for an associative account of delusions publication-title: Brain doi: 10.1093/brain/awm173 – volume: 9 start-page: 97 year: 1971 ident: 10.1016/j.biopsych.2012.02.007_bib41 article-title: The assessment and analysis of handedness: The Edinburgh inventory publication-title: Neuropsychologia doi: 10.1016/0028-3932(71)90067-4 – volume: 168 start-page: 276 year: 2011 ident: 10.1016/j.biopsych.2012.02.007_bib56 article-title: Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2010.09081215 – volume: 35 start-page: 549 year: 2009 ident: 10.1016/j.biopsych.2012.02.007_bib15 article-title: The dopamine hypothesis of schizophrenia: Version III—the final common pathway publication-title: Schizophr Bull doi: 10.1093/schbul/sbp006 – volume: 18 start-page: 247 year: 1993 ident: 10.1016/j.biopsych.2012.02.007_bib51 article-title: The neural basis of drug craving: An incentive-sensitization theory of addiction publication-title: Brain Res Brain Res Rev doi: 10.1016/0165-0173(93)90013-P – volume: 9 start-page: 65 year: 2009 ident: 10.1016/j.biopsych.2012.02.007_bib1 article-title: Dissecting components of reward: ‘liking’, ‘wanting’, and learning publication-title: Curr Opin Pharmacol doi: 10.1016/j.coph.2008.12.014 – volume: 13 start-page: 261 year: 1987 ident: 10.1016/j.biopsych.2012.02.007_bib40 article-title: The positive and negative syndrome scale (PANSS) for schizophrenia publication-title: Schizophr Bull doi: 10.1093/schbul/13.2.261 – volume: 118 start-page: 154 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib35 article-title: Neural correlates of reward processing in schizophrenia—relationship to apathy and depression publication-title: Schizophr Res doi: 10.1016/j.schres.2009.11.007 – volume: 5 start-page: 267 year: 2002 ident: 10.1016/j.biopsych.2012.02.007_bib25 article-title: Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia publication-title: Nat Neurosci doi: 10.1038/nn804 – volume: 67 start-page: 9 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib13 article-title: Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2009.176 – volume: 32 start-page: 1209 year: 2007 ident: 10.1016/j.biopsych.2012.02.007_bib23 article-title: Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response—a double-blind PET study in schizophrenia publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301242 – volume: 94 start-page: 2569 year: 1997 ident: 10.1016/j.biopsych.2012.02.007_bib22 article-title: Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.94.6.2569 – volume: 412 start-page: 43 year: 2001 ident: 10.1016/j.biopsych.2012.02.007_bib26 article-title: Dopamine responses comply with basic assumptions of formal learning theory publication-title: Nature doi: 10.1038/35083500 – volume: 93 start-page: 253 year: 2007 ident: 10.1016/j.biopsych.2012.02.007_bib54 article-title: Anhedonia in schizophrenia: Distinctions between anticipatory and consummatory pleasure publication-title: Schizophr Res doi: 10.1016/j.schres.2007.03.008 – volume: 44 start-page: 707 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib37 article-title: Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia publication-title: J Psychiatr Res doi: 10.1016/j.jpsychires.2009.12.008 – volume: 17 start-page: 9 year: 2002 ident: 10.1016/j.biopsych.2012.02.007_bib52 article-title: Dopaminergic dysfunction in alcoholism and schizophrenia—psychopathological and behavioral correlates publication-title: Eur Psychiatry doi: 10.1016/S0924-9338(02)00628-4 – volume: 31 start-page: 1446 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib8 article-title: Emotional imagery: Assessing pleasure and arousal in the brain's reward circuitry publication-title: Hum Brain Mapp doi: 10.1002/hbm.20948 – volume: 26 start-page: 507 year: 2003 ident: 10.1016/j.biopsych.2012.02.007_bib27 article-title: Parsing reward publication-title: Trends Neurosci doi: 10.1016/S0166-2236(03)00233-9 – volume: 67 start-page: 231 year: 2010 ident: 10.1016/j.biopsych.2012.02.007_bib48 article-title: Increased synaptic dopamine function in associative regions of the striatum in schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2010.10 – volume: 96 start-page: 651 year: 2000 ident: 10.1016/j.biopsych.2012.02.007_bib6 article-title: Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events publication-title: Neuroscience doi: 10.1016/S0306-4522(00)00019-1 – volume: 160 start-page: 13 year: 2003 ident: 10.1016/j.biopsych.2012.02.007_bib53 article-title: Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.160.1.13 – volume: 21 start-page: RC159 year: 2001 ident: 10.1016/j.biopsych.2012.02.007_bib42 article-title: Anticipation of increasing monetary reward selectively recruits nucleus accumbens publication-title: J Neurosci doi: 10.1523/JNEUROSCI.21-16-j0002.2001 |
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| SubjectTerms | Adult Adult and adolescent clinical studies Basal Ganglia - physiopathology Biological and medical sciences Case-Control Studies Female Functional magnetic resonance imaging Functional Neuroimaging Gyrus Cinguli - physiopathology Humans Magnetic Resonance Imaging Male Medical sciences Motivation negative symptoms positive symptoms Prefrontal Cortex - physiopathology Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reward Schizophrenia Schizophrenia - physiopathology Schizophrenic Psychology ventral striatum Ventral Tegmental Area - physiopathology |
| Title | Alterations of the Brain Reward System in Antipsychotic Naïve Schizophrenia Patients |
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