Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis

Pancreatic tumors exhibit enhanced autophagy as compared to any other cancer, making it resistant to chemotherapy. We evaluated the effect of penfluridol against pancreatic cancer. Penfluridol treatment induced apoptosis and inhibited the growth of Panc-1, BxPC-3 and AsPC-1, pancreatic cancer cells...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 26165
Main Authors:	Ranjan, Alok, Srivastava, Sanjay K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.05.2016 Nature Publishing Group
Subjects:	13/109 13/2 14 14/5 38 631/67/1504/1713 64 64/60 692/4028/67/1059 96 Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Caspase Caspase-3 Cell Line, Tumor Chemotherapy Chloroquine Chloroquine - administration & dosage Disease Models, Animal Drug Therapy, Combination Heterografts Humanities and Social Sciences Mice multidisciplinary Neoplasm Transplantation Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Penfluridol - administration & dosage Penfluridol - pharmacology Phagocytosis Phagosomes Science Treatment Outcome Tumors Xenografts
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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