Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Networks of transcription factors (TFs) are thought to determine and maintain the identity of cells. Here we systematically repressed each of 100 TFs with shRNA and carried out global gene expression profiling in mouse embryonic stem (ES) cells. Unexpectedly, only the repression of a handful of TFs...

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Bibliographic Details
Published in:	Scientific reports Vol. 3; no. 1; p. 1390
Main Authors:	Nishiyama, Akira, Sharov, Alexei A., Piao, Yulan, Amano, Misa, Amano, Tomokazu, Hoang, Hien G., Binder, Bernard Y., Tapnio, Richard, Bassey, Uwem, Malinou, Justin N., Correa-Cerro, Lina S., Yu, Hong, Xin, Li, Meyers, Emily, Zalzman, Michal, Nakatake, Yuhki, Stagg, Carole, Sharova, Lioudmila, Qian, Yong, Dudekula, Dawood, Sheer, Sarah, Cadet, Jean S., Hirata, Tetsuya, Yang, Hsih-Te, Goldberg, Ilya, Evans, Michele K., Longo, Dan L., Schlessinger, David, Ko, Minoru S. H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.03.2013 Nature Publishing Group
Subjects:	631/114/2114 631/136/142 631/208/199 631/532/2117 Animals Cell differentiation Cluster Analysis Embryonic Stem Cells - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental Gene Silencing Humanities and Social Sciences Mice Models, Biological multidisciplinary Oct-4 protein Pluripotency RNA Interference Science Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptome
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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