Identifying blood biomarkers for mood disorders using convergent functional genomics

There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the clinicians’ impression is a rate-limiting step in effective treatment and new drug development. We propose, and provide proof of principle for...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 14; no. 2; pp. 156 - 174
Main Authors:	Le-Niculescu, H, Kurian, S M, Yehyawi, N, Dike, C, Patel, S D, Edenberg, H J, Tsuang, M T, Salomon, D R, Nurnberger, J I, Niculescu, A B
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.02.2009 Nature Publishing Group
Subjects:	Adult Adult and adolescent clinical studies Affective disorders Aged Animal models Animals Bayes Theorem Bayesian analysis Behavioral Sciences Biological and medical sciences Biological markers Biological Psychology Biomarkers Biomarkers - blood Bipolar disorder Bipolar disorders Brain Brain - metabolism Brain research Case-Control Studies Cohort Studies Diagnosis Drug development Emotional disorders ErbB-3 protein Female Fibroblast growth factor receptor 1 Gene expression Gene Expression - physiology Gene Expression Profiling - methods Genetic aspects Genomes Genomics Genomics - methods Humans Identification and classification Illnesses Insulin-like growth factor-binding protein 4 Insulin-like growth factor-binding protein 6 Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - genetics Male Medical sciences Medicine Medicine & Public Health Mice Middle Aged Mood Mood disorders Mood Disorders - blood Mood Disorders - classification Mood Disorders - genetics Mood Disorders - pathology Myelin Sheath - genetics Myelin Sheath - metabolism Myelination Neurobiology Neurosciences Oligonucleotide Array Sequence Analysis - methods original-article Peripheral myelin protein 22 Pharmacogenomics Pharmacotherapy Postmortem Changes Predictive Value of Tests Psychiatric research Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reference Values Reproducibility of Results Signal Transduction - genetics Young Adult United States La Jolla California Indiana United States > US Indianapolis Indiana convergent functional genomics bipolar mood brain blood biomarkers Mood disorder Human Affect affectivity Animal model Methodology Central nervous system Biological marker Bipolar disorder Gene expression Genetic determinism Encephalon Mood Genetics Pharmacogenomics
ISSN:	1359-4184, 1476-5578, 1476-5578
Online Access:	Get full text
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