Fatigue-induced increase in intracortical communication between mid/anterior insular and motor cortex during cycling exercise

In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant‐load test at 60% peak oxygen consumption (VO2peak) until volitional exhaustion, electroencephalogr...

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Vydáno v:	The European journal of neuroscience Ročník 34; číslo 12; s. 2035 - 2042
Hlavní autoři:	Hilty, Lea, Langer, Nicolas, Pascual-Marqui, Roberto, Boutellier, Urs, Lutz, Kai
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Oxford, UK Blackwell Publishing Ltd 01.12.2011
Témata:	Adult Cerebral Cortex - anatomy & histology Cerebral Cortex - physiology EEG Electroencephalography exercise Exercise - physiology homeostatic functions Humans lagged phase synchronization Male Motor Cortex - physiology Muscle Fatigue - physiology Nerve Net - anatomy & histology Nerve Net - physiology supraspinal fatigue Young Adult
ISSN:	0953-816X, 1460-9568, 1460-9568
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Abstract	In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant‐load test at 60% peak oxygen consumption (VO2peak) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact‐free periods of 1‐min duration. To quantify fatigue‐induced intracortical communication, mean intra‐hemispheric lagged phase synchronization between mid/anterior insular and motor cortex was calculated: (i) at the beginning of cycling; (ii) at the end of cycling; and (iii) during recovery cycling. Results revealed significantly increased lagged phase synchronization at the end of cycling, which returned to baseline during recovery cycling after subjects’ cessation of exercise. Following previous imaging studies reporting the mid/anterior insular cortex as an essential instance processing a variety of sensory stimuli and signalling forthcoming physiological threat, our results provide further evidence that during a fatiguing exercise this structure might not only integrate and evaluate sensory information from the periphery, but also act in communication with the motor cortex. To the best of our knowledge, this is the first study to empirically demonstrate that muscle fatigue leads to changes in interaction between structures of a brain’s neural network. In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant‐load test at 60% peak oxygen consumption (VO2peak) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact‐free periods of 1‐min duration.
AbstractList	In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant-load test at 60% peak oxygen consumption (VO2peak) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact-free periods of 1-min duration. To quantify fatigue-induced intracortical communication, mean intra-hemispheric lagged phase synchronization between mid/anterior insular and motor cortex was calculated: (i) at the beginning of cycling; (ii) at the end of cycling; and (iii) during recovery cycling. Results revealed significantly increased lagged phase synchronization at the end of cycling, which returned to baseline during recovery cycling after subjects' cessation of exercise. Following previous imaging studies reporting the mid/anterior insular cortex as an essential instance processing a variety of sensory stimuli and signalling forthcoming physiological threat, our results provide further evidence that during a fatiguing exercise this structure might not only integrate and evaluate sensory information from the periphery, but also act in communication with the motor cortex. To the best of our knowledge, this is the first study to empirically demonstrate that muscle fatigue leads to changes in interaction between structures of a brain's neural network. In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant-load test at 60% peak oxygen consumption (VO2peak) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact-free periods of 1-min duration. In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant-load test at 60% peak oxygen consumption (VO(2peak)) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact-free periods of 1-min duration. To quantify fatigue-induced intracortical communication, mean intra-hemispheric lagged phase synchronization between mid/anterior insular and motor cortex was calculated: (i) at the beginning of cycling; (ii) at the end of cycling; and (iii) during recovery cycling. Results revealed significantly increased lagged phase synchronization at the end of cycling, which returned to baseline during recovery cycling after subjects' cessation of exercise. Following previous imaging studies reporting the mid/anterior insular cortex as an essential instance processing a variety of sensory stimuli and signalling forthcoming physiological threat, our results provide further evidence that during a fatiguing exercise this structure might not only integrate and evaluate sensory information from the periphery, but also act in communication with the motor cortex. To the best of our knowledge, this is the first study to empirically demonstrate that muscle fatigue leads to changes in interaction between structures of a brain's neural network.In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant-load test at 60% peak oxygen consumption (VO(2peak)) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact-free periods of 1-min duration. To quantify fatigue-induced intracortical communication, mean intra-hemispheric lagged phase synchronization between mid/anterior insular and motor cortex was calculated: (i) at the beginning of cycling; (ii) at the end of cycling; and (iii) during recovery cycling. Results revealed significantly increased lagged phase synchronization at the end of cycling, which returned to baseline during recovery cycling after subjects' cessation of exercise. Following previous imaging studies reporting the mid/anterior insular cortex as an essential instance processing a variety of sensory stimuli and signalling forthcoming physiological threat, our results provide further evidence that during a fatiguing exercise this structure might not only integrate and evaluate sensory information from the periphery, but also act in communication with the motor cortex. To the best of our knowledge, this is the first study to empirically demonstrate that muscle fatigue leads to changes in interaction between structures of a brain's neural network. In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant‐load test at 60% peak oxygen consumption (VO2peak) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact‐free periods of 1‐min duration. To quantify fatigue‐induced intracortical communication, mean intra‐hemispheric lagged phase synchronization between mid/anterior insular and motor cortex was calculated: (i) at the beginning of cycling; (ii) at the end of cycling; and (iii) during recovery cycling. Results revealed significantly increased lagged phase synchronization at the end of cycling, which returned to baseline during recovery cycling after subjects’ cessation of exercise. Following previous imaging studies reporting the mid/anterior insular cortex as an essential instance processing a variety of sensory stimuli and signalling forthcoming physiological threat, our results provide further evidence that during a fatiguing exercise this structure might not only integrate and evaluate sensory information from the periphery, but also act in communication with the motor cortex. To the best of our knowledge, this is the first study to empirically demonstrate that muscle fatigue leads to changes in interaction between structures of a brain’s neural network. In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant‐load test at 60% peak oxygen consumption (VO2peak) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact‐free periods of 1‐min duration. In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16 healthy male subjects performing a constant-load test at 60% peak oxygen consumption (VO(2peak)) until volitional exhaustion, electroencephalography data were analysed during repetitive, artefact-free periods of 1-min duration. To quantify fatigue-induced intracortical communication, mean intra-hemispheric lagged phase synchronization between mid/anterior insular and motor cortex was calculated: (i) at the beginning of cycling; (ii) at the end of cycling; and (iii) during recovery cycling. Results revealed significantly increased lagged phase synchronization at the end of cycling, which returned to baseline during recovery cycling after subjects' cessation of exercise. Following previous imaging studies reporting the mid/anterior insular cortex as an essential instance processing a variety of sensory stimuli and signalling forthcoming physiological threat, our results provide further evidence that during a fatiguing exercise this structure might not only integrate and evaluate sensory information from the periphery, but also act in communication with the motor cortex. To the best of our knowledge, this is the first study to empirically demonstrate that muscle fatigue leads to changes in interaction between structures of a brain's neural network.
Author	Lutz, Kai Boutellier, Urs Langer, Nicolas Hilty, Lea Pascual-Marqui, Roberto
Author_xml	– sequence: 1 givenname: Lea surname: Hilty fullname: Hilty, Lea organization: Exercise Physiology, Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland – sequence: 2 givenname: Nicolas surname: Langer fullname: Langer, Nicolas organization: Institute of Psychology, Department of Neuropsychology, University of Zurich, Switzerland – sequence: 3 givenname: Roberto surname: Pascual-Marqui fullname: Pascual-Marqui, Roberto organization: The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland – sequence: 4 givenname: Urs surname: Boutellier fullname: Boutellier, Urs organization: Exercise Physiology, Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland – sequence: 5 givenname: Kai surname: Lutz fullname: Lutz, Kai organization: Institute of Psychology, Department of Neuropsychology, University of Zurich, Switzerland
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22097899$$D View this record in MEDLINE/PubMed
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Tataranni, P.A., Gautier, J.F., Chen, K., Uecker, A., Bandy, D., Salbe, A.D., Pratley, R.E., Lawson, M., Reiman, 2001; 91 2006; 31 1988; 271 2004; 29 2002; 53 2000; 3 1994; 372 2002; 113 1988; 39 1997; 112 1975 2011; 96 2002; 957 1983; 50 2003; 19 2008; 586 1935; 189 2007; 34 1998; 44 2011; 369 2007; 28 1976; 231 2003; 90 2009; 98 2004; 38 1997; 58 2000; 525 2002; 87 2002; 88 1999; 13 1996; 490 2006; 120 1999; 96 2001; 16 2005; 39 2010; 30 1996; 6 2001; 98 1974; 37 2003b; 26 2001; 442 2010 1998 1999; 20 1993 2000; 111 2009; 1261 2004; 108 2004; 306 2010; 41 2003a; 13 2004; 115 2007b 2007a 2002; 24 2005; 8 1998; 106 2005; 94 2009; 106 e_1_2_8_28_1 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_3_1 Baciu M.V. (e_1_2_8_2_1) 1999; 20 Borg G. (e_1_2_8_5_1) 1975 e_1_2_8_7_1 e_1_2_8_9_1 e_1_2_8_20_1 e_1_2_8_22_1 e_1_2_8_45_1 e_1_2_8_64_1 e_1_2_8_62_1 e_1_2_8_41_1 e_1_2_8_60_1 e_1_2_8_17_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_59_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_57_1 e_1_2_8_32_1 e_1_2_8_55_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_51_1 e_1_2_8_30_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_46_1 e_1_2_8_27_1 e_1_2_8_48_1 e_1_2_8_4_1 e_1_2_8_6_1 Pascual‐Marqui R.D. (e_1_2_8_43_1) 2002; 24 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_44_1 e_1_2_8_65_1 e_1_2_8_63_1 e_1_2_8_40_1 e_1_2_8_61_1 e_1_2_8_18_1 Hilty L. (e_1_2_8_23_1) 2010 e_1_2_8_39_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_58_1 Reiman E.M. (e_1_2_8_53_1) 1997; 58 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_56_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_54_1 e_1_2_8_52_1 e_1_2_8_50_1
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Snippet	In the present study, intracortical communication between mid/anterior insular and motor cortex was investigated during a fatiguing cycling exercise. From 16...
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SubjectTerms	Adult Cerebral Cortex - anatomy & histology Cerebral Cortex - physiology EEG Electroencephalography exercise Exercise - physiology homeostatic functions Humans lagged phase synchronization Male Motor Cortex - physiology Muscle Fatigue - physiology Nerve Net - anatomy & histology Nerve Net - physiology supraspinal fatigue Young Adult
Title	Fatigue-induced increase in intracortical communication between mid/anterior insular and motor cortex during cycling exercise
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