Protein identification in imaging mass spectrometry through spatially targeted liquid micro‐extractions

Rationale Liquid extraction surface analysis (LESA) can be used to generate spatially directed protein identifications in an imaging mass spectrometry (IMS) workflow. This approach involves the use of robotic micro‐extractions coupled to online liquid chromatography (LC). We have characterized the e...

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Bibliographic Details
Published in:	Rapid communications in mass spectrometry Vol. 32; no. 5; pp. 442 - 450
Main Authors:	Ryan, Daniel J., Nei, David, Prentice, Boone M., Rose, Kristie L., Caprioli, Richard M., Spraggins, Jeffrey M.
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 15.03.2018
Subjects:	Brain Coupling (molecular) Cyclotron resonance Desorption Fourier transforms Identification methods Image acquisition Ionization Ions Liquid chromatography Mass spectrometry Peptides Proteins Proteomics Robotics Scientific imaging Spatial data Spatial resolution Spectroscopy Surface analysis (chemical) Workflow
ISSN:	0951-4198, 1097-0231, 1097-0231
Online Access:	Get full text
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