Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes

The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and out...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Journal of neurology Ročník 263; číslo 7; s. 1349 - 1360
Hlavní autoři: Sepúlveda, Maria, Armangue, Thaís, Martinez-Hernandez, Eugenia, Arrambide, Georgina, Sola-Valls, Nuria, Sabater, Lidia, Téllez, Nieves, Midaglia, Luciana, Ariño, Helena, Peschl, Patrick, Reindl, Markus, Rovira, Alex, Montalban, Xavier, Blanco, Yolanda, Dalmau, Josep, Graus, Francesc, Saiz, Albert
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2016
Springer Nature B.V
Témata:
Adolescent
Adult
Adults
Aged
Animals
Antibodies
Aquaporin 4 - immunology
Autoantibodies - blood
Autoimmunity - physiology
Brain - metabolism
Disability Evaluation
Encephalomyelitis
Female
Follow-Up Studies
Glycoproteins
HEK293 Cells
Humans
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Myelin-Oligodendrocyte Glycoprotein - immunology
Neurology
Neuromyelitis Optica - blood
Neuromyelitis Optica - pathology
Neuromyelitis Optica - physiopathology
Neuroradiology
Neurosciences
Original Communication
Retrospective Studies
Statistics, Nonparametric
Young Adult
Spain
Immunohistochemistry
Longitudinally extensive myelitis
Antibodies to myelin oligodendrocyte glycoprotein
MRI
Optic neuritis
Neuromyelitis optica
Cell-based assays
ISSN:0340-5354, 1432-1459
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD ( p  = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-016-8147-7