Salvia lachnostachys Benth has antitumor and chemopreventive effects against solid Ehrlich carcinoma

Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the ri...

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Vydané v:	Molecular Biology Reports Ročník 46; číslo 5; s. 4827 - 4841
Hlavní autori:	Corso, Claudia Rita, Stipp, Maria Carolina, Adami, Eliana Rezende, da Silva, Luisa Mota, Mariott, Marihá, de Andrade, Sergio Faloni, de Souza Ramos, Edneia Amancio, Klassen, Giseli, Beltrame, Olair Carlos, Queiroz-Telles, José Ederaldo, de Oliveira, Cristhian Santos, Stefanello, Maria Élida Alves, Acco, Alexandra
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Dordrecht Springer Science and Business Media LLC 01.10.2019 Springer Netherlands Springer Nature B.V
Predmet:	Acute toxicity Analgesics Animal Anatomy Animal Biochemistry Animals Anticarcinogenic Agents Anticarcinogenic Agents - chemistry Anticarcinogenic Agents - pharmacology antineoplastic activity Antineoplastic Agents, Phytogenic Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Antioxidants Antitumor activity Biomedical and Life Sciences carcinoma Carcinoma, Ehrlich Tumor Carcinoma, Ehrlich Tumor - genetics Carcinoma, Ehrlich Tumor - metabolism Chemoprevention Chromatography, High Pressure Liquid Cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism cyclins Cytotoxicity Female females Gene Expression Regulation, Neoplastic Glutathione herbaceous plants Histology Inflammation Inoculation Interleukin 10 Life Sciences Lipid peroxidation Methotrexate Mice molecular biology Molecular Structure Morphology N-Acetylglucosaminidase necrosis neoplasm cells Original Article Oxidative Stress Oxidative Stress - drug effects Plant Extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves Plant Leaves - chemistry Reactive Oxygen Species Reactive Oxygen Species - metabolism Salvia Salvia - chemistry Superoxide dismutase toxicity testing Tumor necrosis factor-TNF Tumor necrosis factor-α Antiproliferative Inflammation Solid Ehrlich carcinoma Antitumor Cyclin D1 Salvia lachnostachys
ISSN:	0301-4851, 1573-4978, 1573-4978
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Shrnutí:	Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 10 6 cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg −1 , p.o.), EES (30 and 100 mg kg −1 , p.o.), or methotrexate (2.5 mg kg −1 , i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg −1 EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N -acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0301-4851 1573-4978 1573-4978
DOI:	10.1007/s11033-019-04931-3