Salvia lachnostachys Benth has antitumor and chemopreventive effects against solid Ehrlich carcinoma

Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the ri...

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Veröffentlicht in:Molecular Biology Reports Jg. 46; H. 5; S. 4827 - 4841
Hauptverfasser: Corso, Claudia Rita, Stipp, Maria Carolina, Adami, Eliana Rezende, da Silva, Luisa Mota, Mariott, Marihá, de Andrade, Sergio Faloni, de Souza Ramos, Edneia Amancio, Klassen, Giseli, Beltrame, Olair Carlos, Queiroz-Telles, José Ederaldo, de Oliveira, Cristhian Santos, Stefanello, Maria Élida Alves, Acco, Alexandra
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Dordrecht Springer Science and Business Media LLC 01.10.2019
Springer Netherlands
Springer Nature B.V
Schlagworte:
Acute toxicity
Analgesics
Animal Anatomy
Animal Biochemistry
Animals
Anticarcinogenic Agents
Anticarcinogenic Agents - chemistry
Anticarcinogenic Agents - pharmacology
antineoplastic activity
Antineoplastic Agents, Phytogenic
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants
Antitumor activity
Biomedical and Life Sciences
carcinoma
Carcinoma, Ehrlich Tumor
Carcinoma, Ehrlich Tumor - genetics
Carcinoma, Ehrlich Tumor - metabolism
Chemoprevention
Chromatography, High Pressure Liquid
Cyclin D1
Cyclin D1 - genetics
Cyclin D1 - metabolism
cyclins
Cytotoxicity
Female
females
Gene Expression Regulation, Neoplastic
Glutathione
herbaceous plants
Histology
Inflammation
Inoculation
Interleukin 10
Life Sciences
Lipid peroxidation
Methotrexate
Mice
molecular biology
Molecular Structure
Morphology
N-Acetylglucosaminidase
necrosis
neoplasm cells
Original Article
Oxidative Stress
Oxidative Stress - drug effects
Plant Extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves
Plant Leaves - chemistry
Reactive Oxygen Species
Reactive Oxygen Species - metabolism
Salvia
Salvia - chemistry
Superoxide dismutase
toxicity testing
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Antiproliferative
Inflammation
Solid Ehrlich carcinoma
Antitumor
Cyclin D1
Salvia lachnostachys
ISSN:0301-4851, 1573-4978, 1573-4978
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Abstract Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 10 6  cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg −1 , p.o.), EES (30 and 100 mg kg −1 , p.o.), or methotrexate (2.5 mg kg −1 , i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg −1 EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N -acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.
AbstractList Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 10⁶ cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg⁻¹, p.o.), EES (30 and 100 mg kg⁻¹, p.o.), or methotrexate (2.5 mg kg⁻¹, i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg⁻¹ EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N-acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.
Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 106 cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg-1, p.o.), EES (30 and 100 mg kg-1, p.o.), or methotrexate (2.5 mg kg-1, i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg-1 EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N-acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 106 cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg-1, p.o.), EES (30 and 100 mg kg-1, p.o.), or methotrexate (2.5 mg kg-1, i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg-1 EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N-acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.
Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 10 6  cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg −1 , p.o.), EES (30 and 100 mg kg −1 , p.o.), or methotrexate (2.5 mg kg −1 , i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg −1 EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N -acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.
Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 10  cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg , p.o.), EES (30 and 100 mg kg , p.o.), or methotrexate (2.5 mg kg , i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N-acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.
Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (2 × 106 cells) in female Swiss mice. The animals were treated with vehicle (10 mL kg−1, p.o.), EES (30 and 100 mg kg−1, p.o.), or methotrexate (2.5 mg kg−1, i.p.) for 21 days (early treatment) or 14 days (late treatment) after tumor inoculation, or 10 days before tumor inoculation and continued for 21 days after tumor inoculation (chemopreventive treatment). The acute toxicity test was performed according OECD guidelines Late treatment with EES had no antitumor effect. Early treatment with 100 mg kg−1 EES prevented tumor development, increased tumor necrosis factor-α (TNF-α) levels and decreased tumor superoxide dismutase (SOD) activity, interleukin-10 (IL-10) levels and Cyclin D1 expression, and tumor cell necrosis was observed. Chemopreventive treatment with EES for 10 and 31 days prevented tumor development in the same manner. EES treatment for 31 days decreased hepatic and tumor SOD activity, tumor IL-10 levels and Cyclin D1 expression, and increased tumor reduced glutathione, N-acetylglucosaminidase, reactive oxygen species, lipid peroxidation, TNF-α levels and Nrf2 expression. No toxicity was observed in the acute toxicity assay. In conclusion, EES had an antitumor effect by inhibiting Cyclin D1 expression and increasing inflammation with early and chemopreventive treatment. Modulation of the antioxidant system also contribute for the antitumor effects of EES.
Author Claudia Rita Corso
José Ederaldo Queiroz-Telles
Maria Élida Alves Stefanello
Alexandra Acco
Edneia Amancio de Souza Ramos
Marihá Mariott
Maria Carolina Stipp
Sergio Faloni de Andrade
Eliana Rezende Adami
Luisa Mota da Silva
Cristhian Santos de Oliveira
Olair Carlos Beltrame
Giseli Klassen
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Copyright Springer Nature B.V. 2019
Molecular Biology Reports is a copyright of Springer, (2019). All Rights Reserved.
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ISSN 0301-4851
1573-4978
IngestDate Sun Nov 09 14:05:59 EST 2025
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IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Antiproliferative
Inflammation
Solid Ehrlich carcinoma
Antitumor
Cyclin D1
Salvia lachnostachys
Language English
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crossref_primary_10_1007_s11033_019_04931_3
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PublicationDate 2019-10-01
PublicationDateYYYYMMDD 2019-10-01
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  year: 2019
  text: 2019-10-01
  day: 01
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PublicationSubtitle An International Journal on Molecular and Cellular Biology
PublicationTitle Molecular Biology Reports
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Snippet Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an...
Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an...
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SubjectTerms Acute toxicity
Analgesics
Animal Anatomy
Animal Biochemistry
Animals
Anticarcinogenic Agents
Anticarcinogenic Agents - chemistry
Anticarcinogenic Agents - pharmacology
antineoplastic activity
Antineoplastic Agents, Phytogenic
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants
Antitumor activity
Biomedical and Life Sciences
carcinoma
Carcinoma, Ehrlich Tumor
Carcinoma, Ehrlich Tumor - genetics
Carcinoma, Ehrlich Tumor - metabolism
Chemoprevention
Chromatography, High Pressure Liquid
Cyclin D1
Cyclin D1 - genetics
Cyclin D1 - metabolism
cyclins
Cytotoxicity
Female
females
Gene Expression Regulation, Neoplastic
Glutathione
herbaceous plants
Histology
Inflammation
Inoculation
Interleukin 10
Life Sciences
Lipid peroxidation
Methotrexate
Mice
molecular biology
Molecular Structure
Morphology
N-Acetylglucosaminidase
necrosis
neoplasm cells
Original Article
Oxidative Stress
Oxidative Stress - drug effects
Plant Extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves
Plant Leaves - chemistry
Reactive Oxygen Species
Reactive Oxygen Species - metabolism
Salvia
Salvia - chemistry
Superoxide dismutase
toxicity testing
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Title Salvia lachnostachys Benth has antitumor and chemopreventive effects against solid Ehrlich carcinoma
URI https://cir.nii.ac.jp/crid/1873118015413019136
https://link.springer.com/article/10.1007/s11033-019-04931-3
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