Transcriptional pause release is a rate-limiting step for somatic cell reprogramming

Reactivation of the pluripotency network during somatic cell reprogramming by exogenous transcription factors involves chromatin remodeling and the recruitment of RNA polymerase II (Pol II) to target loci. Here, we report that Pol II is engaged at pluripotency promoters in reprogramming but remains...

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Veröffentlicht in:	Cell stem cell Jg. 15; H. 5; S. 574
Hauptverfasser:	Liu, Longqi, Xu, Yan, He, Minghui, Zhang, Meng, Cui, Fenggong, Lu, Leina, Yao, Mingze, Tian, Weihua, Benda, Christina, Zhuang, Qiang, Huang, Zhijian, Li, Wenjuan, Li, Xiangchun, Zhao, Ping, Fan, Wenxia, Luo, Zhiwei, Li, Yuan, Wu, Yasong, Hutchins, Andrew P, Wang, Dongye, Tse, Hung-Fat, Schambach, Axel, Frampton, Jon, Qin, Baoming, Bao, Xichen, Yao, Hongjie, Zhang, Biliang, Sun, Hao, Pei, Duanqing, Wang, Huating, Wang, Jun, Esteban, Miguel A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.11.2014
Schlagworte:	Animals Base Sequence Cellular Reprogramming - genetics Cyclin-Dependent Kinase 9 - metabolism Embryo, Mammalian - cytology Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Regulation Genome HEK293 Cells Humans Kinetics Kruppel-Like Factor 4 Kruppel-Like Transcription Factors - metabolism Mice Molecular Sequence Data Nuclear Proteins - metabolism Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Positive Transcriptional Elongation Factor B - metabolism Promoter Regions, Genetic Protein Binding - genetics RNA Polymerase II - metabolism RNA-Binding Proteins Transcription Factors - metabolism Transcription, Genetic
ISSN:	1875-9777, 1875-9777
Online-Zugang:	Weitere Angaben
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