Hematopoiesis in numbers

Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypothese...

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Published in:	Trends in immunology Vol. 42; no. 12; pp. 1100 - 1112
Main Authors:	Cosgrove, Jason, Hustin, Lucie S.P., de Boer, Rob J., Perié, Leïla
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.12.2021 Elsevier Limited Elsevier
Subjects:	Animals Bone marrow Cell Count Cell Differentiation Cell size Flow cytometry Hematopoiesis Hematopoietic Stem Cells Hemopoiesis Humans Immunology Life Sciences Lymphatic system Lymphocytes Macromolecules Metadata Mice Progenitor cells Spleen Stem cells Thymus gland
ISSN:	1471-4906, 1471-4981, 1471-4981
Online Access:	Get full text
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Abstract	Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses. Here, we review known numbers in murine and, where possible, human hematopoiesis, and consolidate murine numbers into a set of reference values. We present estimates of cell numbers, division and differentiation rates, cell size, and macromolecular composition for each hematopoietic cell type. We also propose guidelines to improve the reporting of measurements and highlight areas in which quantitative data are lacking. Overall, we show how quantitative approaches can be used to understand key properties of hematopoiesis. Informed by published measurements, our calculations suggest that, in mice, 5 × 103 hematopoietic stem cells (HSCs) can give rise to 1010 hematopoietic cells, while, in humans, 2.5 × 104–1.3 × 106 HSCs can give rise to 1013 mature hematopoietic cellsIn humans and mice, most hematopoietic cells are short-lived, on the order of days or weeks. As such, blood cells are constantly being produced to maintain blood homeostasis. In humans, blood cells account for 90% of all cellular turnover.Our calculations predict that the amount of murine and human myeloid and erythroid cells produced each day are approximately the same order of magnitude, despite the absolute number of erythroid cells being several orders of magnitude higher than myeloid cells in both species. This is due to large differences in the expected lifespan of each cell type.Despite recent progress, reports on the absolute measurements of cell numbers across tissues throughout lifespans are missing for many cell types and species, particularly in humans; this represents a fruitful area of empirical investigation.
AbstractList	Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses. Here, we review known numbers in murine and, where possible, human hematopoiesis, and consolidate murine numbers into a set of reference values. We present estimates of cell numbers, division and differentiation rates, cell size, and macromolecular composition for each hematopoietic cell type. We also propose guidelines to improve the reporting of measurements and highlight areas in which quantitative data are lacking. Overall, we show how quantitative approaches can be used to understand key properties of hematopoiesis.Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses. Here, we review known numbers in murine and, where possible, human hematopoiesis, and consolidate murine numbers into a set of reference values. We present estimates of cell numbers, division and differentiation rates, cell size, and macromolecular composition for each hematopoietic cell type. We also propose guidelines to improve the reporting of measurements and highlight areas in which quantitative data are lacking. Overall, we show how quantitative approaches can be used to understand key properties of hematopoiesis. Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses. Here, we review known numbers in murine and, where possible, human hematopoiesis, and consolidate murine numbers into a set of reference values. We present estimates of cell numbers, division and differentiation rates, cell size, and macromolecular composition for each hematopoietic cell type. We also propose guidelines to improve the reporting of measurements and highlight areas in which quantitative data are lacking. Overall, we show how quantitative approaches can be used to understand key properties of hematopoiesis. Informed by published measurements, our calculations suggest that, in mice, 5 × 103 hematopoietic stem cells (HSCs) can give rise to 1010 hematopoietic cells, while, in humans, 2.5 × 104–1.3 × 106 HSCs can give rise to 1013 mature hematopoietic cellsIn humans and mice, most hematopoietic cells are short-lived, on the order of days or weeks. As such, blood cells are constantly being produced to maintain blood homeostasis. In humans, blood cells account for 90% of all cellular turnover.Our calculations predict that the amount of murine and human myeloid and erythroid cells produced each day are approximately the same order of magnitude, despite the absolute number of erythroid cells being several orders of magnitude higher than myeloid cells in both species. This is due to large differences in the expected lifespan of each cell type.Despite recent progress, reports on the absolute measurements of cell numbers across tissues throughout lifespans are missing for many cell types and species, particularly in humans; this represents a fruitful area of empirical investigation. Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~10 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses. Here, we review known numbers in murine and, where possible, human hematopoiesis, and consolidate murine numbers into a set of reference values. We present estimates of cell numbers, division and differentiation rates, cell size, and macromolecular composition for each hematopoietic cell type. We also propose guidelines to improve the reporting of measurements and highlight areas in which quantitative data are lacking. Overall, we show how quantitative approaches can be used to understand key properties of hematopoiesis. Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses. Here, we review known numbers in murine and, where possible, human hematopoiesis, and consolidate murine numbers into a set of reference values. We present estimates of cell numbers, division and differentiation rates, cell size, and macromolecular composition for each hematopoietic cell type. We also propose guidelines to improve the reporting of measurements and highlight areas in which quantitative data are lacking. Overall, we show how quantitative approaches can be used to understand key properties of hematopoiesis.
Author	Perié, Leïla Hustin, Lucie S.P. de Boer, Rob J. Cosgrove, Jason
Author_xml	– sequence: 1 givenname: Jason surname: Cosgrove fullname: Cosgrove, Jason organization: Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, Paris, France – sequence: 2 givenname: Lucie S.P. surname: Hustin fullname: Hustin, Lucie S.P. organization: Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, Paris, France – sequence: 3 givenname: Rob J. surname: de Boer fullname: de Boer, Rob J. organization: Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands – sequence: 4 givenname: Leïla orcidid: 0000-0003-0798-4498 surname: Perié fullname: Perié, Leïla email: Leila.Perie@curie.fr organization: Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, Paris, France
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Snippet	Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We... Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~10 blood and immune cells distributed throughout the human body. We...
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SubjectTerms	Animals Bone marrow Cell Count Cell Differentiation Cell size Flow cytometry Hematopoiesis Hematopoietic Stem Cells Hemopoiesis Humans Immunology Life Sciences Lymphatic system Lymphocytes Macromolecules Metadata Mice Progenitor cells Spleen Stem cells Thymus gland
Title	Hematopoiesis in numbers
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