MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome

To address the impact of cellular origin on acute myeloid leukemia (AML), we generated an inducible transgenic mouse model for MLL-AF9-driven leukemia. MLL-AF9 expression in long-term hematopoietic stem cells (LT-HSC) in vitro resulted in dispersed clonogenic growth and expression of genes involved...

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Bibliographic Details
Published in:	Cancer cell Vol. 30; no. 1; pp. 43 - 58
Main Authors:	Stavropoulou, Vaia, Kaspar, Susanne, Brault, Laurent, Sanders, Mathijs A, Juge, Sabine, Morettini, Stefano, Tzankov, Alexandar, Iacovino, Michelina, Lau, I-Jun, Milne, Thomas A, Royo, Hélène, Kyba, Michael, Valk, Peter J M, Peters, Antoine H F M, Schwaller, Juerg
Format:	Journal Article
Language:	English
Published:	United States 11.07.2016
Subjects:	Animals Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition Gene Expression Profiling - methods Gene Expression Regulation, Leukemic Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Mice Mice, Transgenic Myeloid-Lymphoid Leukemia Protein - genetics Myeloid-Lymphoid Leukemia Protein - metabolism Neoplasm Invasiveness Neoplasms, Experimental Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Prognosis Tumor Cells, Cultured Zinc Finger E-box-Binding Homeobox 1 - genetics MLL-AF9 acute myeloid leukemia invasion stem cell poor overall survival EMT
ISSN:	1878-3686
Online Access:	Get more information
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