Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney and heart. Glioma-associated oncogene 1 expressing (Gli1 ) cells are a major source of activated fibroblasts in multiple organs, but the links between injury, inflammation, and Gli1 cell exp...

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Bibliographic Details

Published in:	Science translational medicine Vol. 15; no. 698; p. eabn0736
Main Authors:	O'Sullivan, Eoin D, Mylonas, Katie J, Xin, Cuiyan, Baird, David P, Carvalho, Cyril, Docherty, Marie-Helena, Campbell, Ross, Matchett, Kylie P, Waddell, Scott H, Walker, Alexander D, Gallagher, Kevin M, Jia, Siyang, Leung, Steve, Laird, Alexander, Wilflingseder, Julia, Willi, Michaela, Reck, Maximilian, Finnie, Sarah, Pisco, Angela, Gordon-Keylock, Sabrina, Medvinsky, Alexander, Boulter, Luke, Henderson, Neil C, Kirschner, Kristina, Chandra, Tamir, Conway, Bryan R, Hughes, Jeremy, Denby, Laura, Bonventre, Joseph V, Ferenbach, David A
Format:	Journal Article
Language:	English
Published:	United States 31.05.2023
Subjects:	Animals Fibrosis Hedgehog Proteins - metabolism Humans Inflammation Mice NF-kappa B Renal Insufficiency, Chronic Tumor Necrosis Factors Zinc Finger Protein GLI1
ISSN:	1946-6242, 1946-6242
Online Access:	Get more information
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