Human telomerase inhibition by substituted acridine derivatives

A series of 3,6-disubstituted acridine derivatives have been rationally designed as telomerase inhibitors. They have been designed on the basis that inhibition of telomerase occurs by stabilising G-quadruplex structures formed by the folding of telomeric DNA. The most potent inhibitors have IC 50 va...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 9; no. 17; pp. 2463 - 2468
Main Authors:	Harrison, R. John, Gowan, Sharon M., Kelland, Lloyd R., Neidle, Stephen
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 06.09.1999 Elsevier
Subjects:	Acridines - chemistry Acridines - pharmacology Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects Humans Medical sciences Pharmacology. Drug treatments Telomerase - antagonists & inhibitors Tumor Cells, Cultured Antineoplastic agent Human Enzyme Aminoamide Nitrogen heterocycle Transferases Acridine derivatives Enzyme inhibitor Cytotoxicity Tricyclic compound In vitro Ovary Nucleotidyltransferases Cell line Structure activity relation Tertiary amine Aromatic compound Chemical synthesis DNA-directed DNA polymerase
ISSN:	0960-894X, 1464-3405
Online Access:	Get full text
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