Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects

Purpose The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorptio...

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Bibliographic Details
Published in:	European journal of nutrition Vol. 57; no. 3; pp. 929 - 938
Main Authors:	Purpura, Martin, Lowery, Ryan P., Wilson, Jacob M., Mannan, Haider, Münch, Gerald, Razmovski-Naumovski, Valentina
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2018 Springer Nature B.V
Subjects:	absorption Adult Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - metabolism Antioxidants - administration & dosage Antioxidants - analysis Antioxidants - chemistry Antioxidants - metabolism Area Under Curve Bioavailability Chemistry Chemistry and Materials Science Cohort Studies Cross-Over Studies Curcumin Curcumin - administration & dosage Curcumin - analogs & derivatives Curcumin - analysis Curcumin - chemistry Curcumin - metabolism Cyclodextrin Diarylheptanoids Dietary Supplements dispersibility Double-Blind Method Essential oils Female Food Additives - chemistry Food Handling gamma-cyclodextrin gamma-Cyclodextrins - chemistry Human subjects Humans Intestinal Absorption Intestine Lipophilic Male Nutrition Nutritive Value Oral administration Original Contribution Pharmacokinetics rhizomes Solubility turmeric Young Adult Cyclodextrin Curcumin Bioavailability Plasma pharmacokinetics Humans
ISSN:	1436-6207, 1436-6215, 1436-6215
Online Access:	Get full text
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