Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects

Purpose The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorptio...

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Vydáno v:European journal of nutrition Ročník 57; číslo 3; s. 929 - 938
Hlavní autoři: Purpura, Martin, Lowery, Ryan P., Wilson, Jacob M., Mannan, Haider, Münch, Gerald, Razmovski-Naumovski, Valentina
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2018
Springer Nature B.V
Témata:
absorption
Adult
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - blood
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - metabolism
Antioxidants - administration & dosage
Antioxidants - analysis
Antioxidants - chemistry
Antioxidants - metabolism
Area Under Curve
Bioavailability
Chemistry
Chemistry and Materials Science
Cohort Studies
Cross-Over Studies
Curcumin
Curcumin - administration & dosage
Curcumin - analogs & derivatives
Curcumin - analysis
Curcumin - chemistry
Curcumin - metabolism
Cyclodextrin
Diarylheptanoids
Dietary Supplements
dispersibility
Double-Blind Method
Essential oils
Female
Food Additives - chemistry
Food Handling
gamma-cyclodextrin
gamma-Cyclodextrins - chemistry
Human subjects
Humans
Intestinal Absorption
Intestine
Lipophilic
Male
Nutrition
Nutritive Value
Oral administration
Original Contribution
Pharmacokinetics
rhizomes
Solubility
turmeric
Young Adult
Cyclodextrin
Curcumin
Bioavailability
Plasma pharmacokinetics
Humans
ISSN:1436-6207, 1436-6215, 1436-6215
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Shrnutí:Purpose The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO). Methods Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period. Results CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC 0−12 ) in comparison with the unformulated StdC. Conclusion The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans.
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ISSN:1436-6207
1436-6215
1436-6215
DOI:10.1007/s00394-016-1376-9