Impact of processing and analysis methodology on thalamic susceptibility assessment in multiple sclerosis

Studies using quantitative susceptibility mapping (QSM) to investigate thalamic iron levels in people with multiple sclerosis (pwMS) have yielded inconsistent results. It has been speculated that cohort differences are responsible for these inconsistencies, leading to the phenomenological "earl...

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Bibliographic Details
Published in:	PloS one Vol. 20; no. 11; p. e0332478
Main Authors:	Salman, Fahad, Bergsland, Niels, Dwyer, Michael G., Reeves, Jack A., Ramesh, Abhisri, Jakimovski, Dejan, Weinstock-Guttman, Bianca, Zivadinov, Robert, Schweser, Ferdinand
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 14.11.2025 Public Library of Science (PLoS)
Subjects:	Adult Age differences Algorithms Analysis Brain Mapping - methods Case-Control Studies Cerebrospinal fluid Development and progression Diagnosis Dipoles Disease Susceptibility Female Humans Hypotheses Image Processing, Computer-Assisted - methods Impact analysis Iron - metabolism Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical examination Middle Aged Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Parameters Regularization Replication Risk factors Segmentation Susceptibility Thalamus Thalamus - diagnostic imaging Thalamus - metabolism Thalamus - pathology United States
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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