Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalized the increase in proton leak and reduced mitochon...

Full description

Saved in:

Bibliographic Details
Published in:	eLife Vol. 9
Main Authors:	Chiao, Ying Ann, Zhang, Huiliang, Sweetwyne, Mariya, Whitson, Jeremy, Ting, Ying Sonia, Basisty, Nathan, Pino, Lindsay K, Quarles, Ellen, Nguyen, Ngoc-Han, Campbell, Matthew D, Zhang, Tong, Gaffrey, Matthew J, Merrihew, Gennifer, Wang, Lu, Yue, Yongping, Duan, Dongsheng, Granzier, Henk L, Szeto, Hazel H, Qian, Wei-Jun, Marcinek, David, MacCoss, Michael J, Rabinovitch, Peter
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 10.07.2020 eLife Sciences Publications, Ltd
Subjects:	Age Aging Aging - drug effects Animals BASIC BIOLOGICAL SCIENCES Cardiac function Cardiomyocytes Catalase Connectin diastolic dysfunction Energy Metabolism Female Fitness equipment Heart Diseases - drug therapy Heart Diseases - physiopathology Human Biology and Medicine Male Mice Mice, Inbred C57BL Mitochondria Mitochondria - physiology Mitochondrial DNA Oligopeptides - administration & dosage Oxidation-Reduction Oxidative Stress Phenotypes Phosphorylation Redox properties Rodents Running human biology mouse mitochondria diastolic dysfunction cardiac function medicine aging oxidative stress
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!