Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model

Novel antimicrobials for effective treatment of uncomplicated gonorrhea are essential, and the first-in-class, oral spiropyrimidinetrione DNA gyrase B inhibitor zoliflodacin appears promising. Using our newly developed Hollow Fiber Infection Model (HFIM), the pharmacodynamics of zoliflodacin was exa...

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Bibliographic Details
Published in:	Frontiers in pharmacology Vol. 13; p. 874176
Main Authors:	Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Franceschi, Francois, Brown, David, Louie, Arnold, Drusano, George, Unemo, Magnus
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 14.04.2022
Subjects:	antimicrobial treatment gyrB hollow fiber infection model mutant Neisseria gonorrhoeae pharmacodynamics pharmacokinetics Pharmacology zoliflodacin gyrB Neisseria gonorrhoeae zoliflodacin pharmacodynamics pharmacokinetics hollow fiber infection model mutant antimicrobial treatment
ISSN:	1663-9812, 1663-9812
Online Access:	Get full text
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