Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model

Novel antimicrobials for effective treatment of uncomplicated gonorrhea are essential, and the first-in-class, oral spiropyrimidinetrione DNA gyrase B inhibitor zoliflodacin appears promising. Using our newly developed Hollow Fiber Infection Model (HFIM), the pharmacodynamics of zoliflodacin was exa...

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Veröffentlicht in:	Frontiers in pharmacology Jg. 13; S. 874176
Hauptverfasser:	Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Franceschi, Francois, Brown, David, Louie, Arnold, Drusano, George, Unemo, Magnus
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 14.04.2022
Schlagworte:	antimicrobial treatment gyrB hollow fiber infection model mutant Neisseria gonorrhoeae pharmacodynamics pharmacokinetics Pharmacology zoliflodacin gyrB Neisseria gonorrhoeae zoliflodacin pharmacodynamics pharmacokinetics hollow fiber infection model mutant antimicrobial treatment
ISSN:	1663-9812, 1663-9812
Online-Zugang:	Volltext
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