Identifying and analyzing sepsis states: A retrospective study on patients with sepsis in ICUs

Sepsis accounts for more than 50% of hospital deaths, and the associated cost ranks the highest among hospital admissions in the US. Improved understanding of disease states, progression, severity, and clinical markers has the potential to significantly improve patient outcomes and reduce cost. We d...

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Bibliographic Details
Published in:PLOS digital health Vol. 1; no. 11; p. e0000130
Main Authors: Fang, Chih-Hao, Ravindra, Vikram, Akhter, Salma, Adibuzzaman, Mohammad, Griffin, Paul, Subramaniam, Shankar, Grama, Ananth
Format: Journal Article
Language:English
Published: United States Public Library of Science 01.11.2022
Public Library of Science (PLoS)
Subjects:
Biology and Life Sciences
Biomarkers
Comorbidity
Decision making
Engineering and Technology
Infections
Intensive care
Medicine and Health Sciences
Mortality
Multiple organ dysfunction syndrome
Patients
Physical Sciences
Sepsis
Vital signs
United States > US
ISSN:2767-3170, 2767-3170
Online Access:Get full text
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Summary:Sepsis accounts for more than 50% of hospital deaths, and the associated cost ranks the highest among hospital admissions in the US. Improved understanding of disease states, progression, severity, and clinical markers has the potential to significantly improve patient outcomes and reduce cost. We develop a computational framework that identifies disease states in sepsis and models disease progression using clinical variables and samples in the MIMIC-III database. We identify six distinct patient states in sepsis, each associated with different manifestations of organ dysfunction. We find that patients in different sepsis states are statistically significantly composed of distinct populations with disparate demographic and comorbidity profiles. Our progression model accurately characterizes the severity level of each pathological trajectory and identifies significant changes in clinical variables and treatment actions during sepsis state transitions. Collectively, our framework provides a holistic view of sepsis, and our findings provide the basis for future development of clinical trials, prevention, and therapeutic strategies for sepsis.
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The authors have declared that no competing interests exist.
ISSN:2767-3170
2767-3170
DOI:10.1371/journal.pdig.0000130